Cloning and characterization of anti-cathepsin L single chain variable fragment whose expression inhibits procathepsin L secretion in human melanoma cells

Biochemical Journal

Volumn 367, Issue 1, 2002, Pages 219-227

  Guillaume Rousselet, Nathalie ^a   Jean, Didier ^a   Frade, Raymond ^a  

^a Parc Scientifique de Luminy   (France)

Author keywords

Cell therapy; Cysteine protease; Third component of complement

Indexed keywords

AMINO ACIDS; CELLS; CHARACTERIZATION; CLONING; MONOCLONAL ANTIBODIES; TUMORS;

CELL THERAPY; MOLECULAR TOOLS;

BIOCHEMISTRY;

CATHEPSIN L; COMPLEMENTARY DNA; HYBRID PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY 3D8; PROCATHEPSIN L; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; CATHEPSIN; CYSTEINE PROTEINASE; ENZYME PRECURSOR; GLUTATHIONE TRANSFERASE; MONOCLONAL ANTIBODY;

ADOPTIVE IMMUNOTHERAPY; AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY ISOLATION; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOGLOBULIN VARIABLE REGION; MELANOMA CELL; METASTASIS; MOLECULAR CLONING; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECRETION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CHEMISTRY; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; IMMUNOLOGY; LYMPH NODE METASTASIS; MELANOMA; METABOLISM; MOLECULAR GENETICS; MOUSE; PLASMID; SECRETION; SERODIAGNOSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CATHEPSINS; CLONING, MOLECULAR; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENZYME PRECURSORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC VECTORS; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN VARIABLE REGION; LYMPHATIC METASTASIS; MELANOMA; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; PLASMIDS; PRECIPITIN TESTS; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036796424     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020350     Document Type: Article

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