Phase II study of docetaxel and gemcitabine combination chemotherapy in non-small-cell lung cancer patients failing previous chemotherapy

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 25, Issue 5, 2002, Pages 509-512

  Chen, Yuh Min ^a   Perng, Reury Perng ^a   Lin, Wei Chun ^a   Wu, Hsiao Wei ^a   Tsai, Chun Ming ^a   Whang Peng, Jacqueline ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Cisplatin; Docetaxel; Gemcitabine; Non small cell lung cancer; Salvage chemotherapy

Indexed keywords

DEXAMETHASONE; DOCETAXEL; GEMCITABINE;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW SUPPRESSION; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; HUMAN; INTERSTITIAL PNEUMONIA; LUNG NON SMALL CELL CANCER; LUNG TOXICITY; MALE; NAUSEA; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; THROMBOCYTOPENIA; VOMITING;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; DEOXYCYTIDINE; HUMANS; LUNG DISEASES, INTERSTITIAL; LUNG NEOPLASMS; MIDDLE AGED; PACLITAXEL; QUALITY OF LIFE; SALVAGE THERAPY; SURVIVAL ANALYSIS; TAXOIDS;

EID: 0036794926     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-200210000-00017     Document Type: Article

References (18)

1. Grilli R, Oxman AD, Julian JA. Chemotherapy for advanced non-small-cell lung cancer: How much benefit is enough? J Clin Oncol 1993;11:1866-72.
2. Souquet PJ, Chauvin F, Boissel JP, et al. Polychemotherapy in advanced non small cell lung cancer: a meta-analysis. Lancet 1993;342:19-21.
3. Belani CP. Single agents in the second-line treatment of non-small cell lung cancer. Semin Oncol 1998;25(suppl 8):10-4.
4. Fossella FV, Rigas J. The use of docetaxel (Taxotere) in patients with advanced non-small cell lung cancer previously treated with platinum-containing chemotherapy regimens. Semin Oncol 1999;26(suppl 11):9-12.
5. Fossella FV, DeVore R, Kerr RN, et al. Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. J Clin Oncol 2000;18:2354-62.
6. Perng RP, Chen YM, Liu JM, et al. Gemcitabine versus the combination of cisplatin and etoposide in patients with inoperable non-small-cell lung cancer in a phase II randomized study. J Clin Oncol 1997;15:2097-102.
7. Sandler AB, Nemunaitis J, Denham C, et al. Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2000;18:122-30.
8. Crino L, Mosconi AM, Scagliotti GV, et al. Gemcitabine as second-line treatment for relapsing or refractory advanced non-small cell lung cancer: a phase II trial. Semin Oncol 1998;25(suppl 9):23-6.
9. Van Kooten M, Traine G, Cinat G, et al. Single-agent gemcitabine in pretreated patients with non-small-cell lung cancer: results of an Argentinean multicentre phase II trial. Br J Cancer 1999;81:846-9.
10. Kelly K. The role of single-agent gemcitabine in the treatment of non-small-cell lung cancer. Ann Oncol 1999;10(suppl 5):S53-6.
11. Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982;5:649-55.
12. Francis PA, Rigas JR, Kris MG, et al. Phase II trial of docetaxel in patients with stage III and IV non-small-cell lung cancer. J Clin Oncol 1994;12:1232-7.
13. Fossella FV, Lee JS, Murphy WK, et al. Phase II study of docetaxel for recurrent or metastatic non-small-cell lung cancer. J Clin Oncol 1994;12:1238-44.
14. Fossella FV, Lee JS, Shin DM, et al. Phase II study of docetaxel for advanced or metastatic platinum-refractory non-small-cell lung cancer. J Clin Oncol 1995;13:645-51.
15. Perng RP, Shih JF, Chen YM, et al. A phase II study of single agent docetaxel chemotherapy for non-small-cell lung cancer. Jpn J Clin Oncol 2000;30:429-34.
16. Kunitoh H, Watanabe K, Onoshi T, et al. Phase II trial of docetaxel in previously untreated advanced non-small-cell lung cancer: a Japanese cooperative study. J Clin Oncol 1996;14:1649-55.
17. Clinical practice guidelines for the treatment of unresectable non-small-cell lung cancer. J Clin Oncol 1997;15:2996-3018.
18. Georgoulias V, Kouroussis C, Androulakis N, et al. Front-line treatment of advanced non-small-cell lung cancer with docetaxel and gemcitabine: a multicenter phase II trial. J Clin Oncol 1999;17:914-20.