Pharmacodynamics of mivacurium chloride in 13- to 18-yrs-old adolescents with thermal injury

British Journal of Anaesthesia

Volumn 89, Issue 4, 2002, Pages 580-585

  Martyn, J A J ^a   Chang, Y ^a   Goudsouzian, N G ^a   Patel, S S ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Complications, burn injury; Enzymes, plasma cholinesterase; Neuromuscular block, mivacurium

Indexed keywords

BENZODIAZEPINE; CHOLINERGIC RECEPTOR; CHOLINESTERASE; CINCHOCAINE; DRUG METABOLIZING ENZYME; FENTANYL; GENTAMICIN; HALOTHANE; MIVACURIUM; MORPHINE; NARCOTIC AGENT; NEUROMUSCULAR BLOCKING AGENT; NITROUS OXIDE PLUS OXYGEN; OXYGEN; PROPOFOL;

ADOLESCENT; ADULT; AGE; ANESTHETIC RECOVERY; ARTICLE; BODY SURFACE; BOLUS INJECTION; BURN; CHOLINESTERASE BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG METABOLISM; DRUG OVERDOSE; ENZYME ACTIVITY; FEMALE; HUMAN; MALE; NEUROMUSCULAR BLOCKING; PARALYSIS; PATIENT CODING; PHARMACODYNAMICS; PREMEDICATION; PRIORITY JOURNAL; STANDARD; THERMAL INJURY; TIME;

EID: 0036794282     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aef234     Document Type: Article

References (25)

1. Ibebunjo C, Martyn JAJ. Thermal injury induces greater resistance to d-tubocurarine in local than in distant muscles in the rat. Anesth Analg 2000; 91: 1243-9
2. Martyn JAJ, White DA, Gronert GH, Jaffe RS, Ward J. Up- and down-regulation of skeletal muscle acetylcholine receptors. Effects on neuromuscular blockers. Anesthesiology 1992; 76: 822-43
3. Viby-Mogensen J, Hanel HK, Hansen E, Sorensen B, Graae J. Serum cholinesterase activity in burned patients I: biochemical findings. Acta Anaesthesiol Scand 1975; 19: 159-68
4. Kamolz LP, Andel H, Greher M, Ploner M, Meissl G, Frey M. Serum cholinesterase activity reflects morbidity in burned patients. Burns 2002; 28: 47-50
5. Martyn JAJ, Goudsouzian NG, Chang YC, Szyfelbein SK, Schwartz AE, Patel SS. Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury. Anesthesiology 2000; 92: 31-7
6. Goudsouzian NG, Martyn JAJ. Potentiation of mivacurium by rocuronium is age- and time dependent: a study in children, adolescents and young and elderly adults. J Clin Pharmacol 1997; 37: 649-55
7. Mills AK, Martyn JAJ. Evaluation of atracurium neuromuscular blockade in paediatric patients with burn injury. Br J Anaesth 1988; 60: 450-5
8. Dwersteg JF, Pavlin EG, Heimbach DM. Patients with burns are resistant to atracurium. Anesthesiology 1986; 65: 517-20
9. Mills AK, Martyn JAJ. Neuromuscular blockade with vecuronium in paediatric patients with burn injury. Br J Clin Pharmac 1989; 28: 155-9
10. Martyn JAJ, Liu LMP, Szyfelbein SK, Ambalavanar ES, Goudsouzian NG. The neuromuscular effects of pancuronium in burned children. Anesthesiology 1983; 59: 561-4
11. Martyn JAJ, Goudsouzian NG, Matteo RS, Liu LMP, Szyfelbein SK, Kaplan RF. Metocurine requirements and plasma concentrations in burned paediatric patients. Br J Anaesth 1983; 55: 263-8
12. Marathe PH, Dwersteg JF, Pavlin EG, Haschke RH, Heimbach DM, Slattery JT. Effect of thermal injury on the pharmacokinetics and pharmacodynamics of atracurium in humans. Anesthesiology 1989; 70: 752-5
13. Werba AE, Neiger FX, Bayer GS, Schultz AM, Maitz PKM, Wolrab CH. Pharmacodynamics of mivacurium in severely burned patients. Burns 1996; 22: 62-4
14. Martyn JAJ, Abernathy DR, Greenblatt DJ. Plasma protein binding of drugs after burn injury. Clin Pharmacol Ther 1984; 35: 535-9
15. Martyn JAJ, Bishop AL, Oliveri MF. Pharmacokinetics and pharmacodynamics of ranitidine after burn injury. Clin Pharmacol Ther 1992; 51: 408-14
16. Martyn JAJ. Clinical pharmacology and drug therapy in the burned patient. Anesthesiology 1986; 65: 67-75
17. Kim C, Martyn JAJ, Fuke N. Burn injury to trunk of rat causes denervation-like responses in the gastrocnemius muscle. J Appl Physiol 1988; 65: 1745-51
18. Ibebunjo C, Martyn JAJ. Disparate dysfunction of skeletal muscles located near to and distant from burn site in the rat. Muscle Nerve 2001; 24: 1283-94
19. Perov S, Prasad JK, Nagelhout J, Walczyk W, Martyn JAJ. Upregulation of acetylcholine in a severely burned patient. Anesthesiology 1994; 81: A1089
20. Ostergaard D, Jensen FS, Jensen E, Skovgaard LT, Viby-Mogensen J. Influence of plasma cholinesterase activity on recovery from mivacurium-induced neuromuscular blockade in phenotypically normal patients. Acta Anaesth Scand 1992; 36: 702-6
21. Beaufort TM, Nigrovic V, Proost JH, Howertjes MC, Wierda JMKH. Inhibition of enzyme degradation of suxamethonium and mivacurium increases onset time of submaximal neuromuscular block. Anesthesiology 1998; 89: 707-14
22. Markakis DA, Hart PS, Lau M, Brown R, Fisher DM. Does age or pseudocholinesterase activity predict mivacurium infusion rate in children? Anesth Analg 1996; 82: 39-43
23. Martyn JAJ. Succinylcholine hyperkalemia after burns. Anesthesiology 1999; 91: 321-2
24. Hagen J, Martyn JAJ, Szyfelbein SKS, Goudsouzian NG. Cardiovascular and neuromuscular responses to high-dose pancuronium-metocurine in pediatric burned and reconstructive patients. Anesth Analg 1986; 65: 1340-5
25. Abdi S, Cortilla J, Martyn JAJ. Burn-injury related anesthetic emergencies. Semin Anesth 1998; 17: 139-46