High-dose glucocorticoids inhibit proliferation of rat olfactory epithelium

Annals of Otology, Rhinology and Laryngology

Volumn 111, Issue 10, 2002, Pages 909-911

  Ohta, Yasushi ^a   Takanosawa, Minako ^a   Matumoto, Chiori ^a   Makino, Nobuko ^a   Ishimoto, Shinichi ^b   Ichimura, Keiichi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Glucocorticoids; Olfactory epithelium; Proliferation

Indexed keywords

CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID; GROWTH FACTOR; KI 67 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; MALE; NONHUMAN; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL DIVISION; DEXAMETHASONE; GLUCOCORTICOIDS; IMMUNOHISTOCHEMISTRY; INJECTIONS, SUBCUTANEOUS; KI-67 ANTIGEN; MALE; OLFACTORY MUCOSA; RATS; TIME FACTORS;

EID: 0036793865     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348940211101008     Document Type: Article

References (7)

1. Jafek BW, Moran DT, Eller PM, Rowley JC III, Jafek TB. Steroid-dependent anosmia. Arch Otolaryngol Head Neck Surg 1987;113:547-9.
2. Graziadei PPC, Graziadei GAM. Neurogenesis and neuron regeneration in the olfactory system of mammals. 1. Morphological aspects of differentiation and structural organization of olfactory sensory neurons. J Neurocytol 1979;8:1-18.
3. Smith MD, Healy E, Thompson V, Morley A, Rees JL. Use of in situ detection of histone mRNA in the assessment of epidermal proliferation: comparison with the Ki67 antigen and BrdU incorporation. Br J Dermatol 1995;132:359-66.
4. Ohta Y, Ichimura K. Proliferation markers, proliferating cell nuclear antigen, Ki67, 5-bromo-2′-deoxyuridine, and cyclin D1 in mouse olfactory epithelium. Ann Otol Rhinol Laryngol 2000;109:1046-8.
5. Ohta Y, Ichimura K. Globosal basal cells are identified as proliferating cells in mouse olfactory epithelium. Ann Otol Rhinol Laryngol 2001;110:53-5.
6. Robinson AM, Kern RC, Foster JD, Fong KG, Pitovski DZ. Expression of glucocorticoid receptor mRNA and protein in the olfactory mucosa: physiologic and pathophysiologic implications. Laryngoscope 1998;108:1238-42.
7. Chedid M, Hoyle JR, Csaky KG, Rubin JS. Glucocorticoids inhibit keratinocyte growth factor production in primary dermal fibroblasts. Endocrinology 1996;137:2232-7.