Antimicrobial release kinetics from polymethylmethacrylate in a novel continuous flow chamber

Clinical Orthopaedics and Related Research

Volumn 403, Issue , 2002, Pages 49-53

  Perry, Archie C ^a   Rouse, Mark S ^a   Khaliq, Yasmin ^a   Piper, Kerryl E ^a   Hanssen, Arlen D ^a   Osmon, Douglas R ^a   Steckelberg, James M ^a   Patel, Robin ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; ANTIINFECTIVE AGENT; GENTAMICIN; POLY(METHYL METHACRYLATE); TOBRAMYCIN; VANCOMYCIN; DRUG CARRIER; VASODILATOR AGENT;

BIOASSAY; CONFERENCE PAPER; CONTROLLED DRUG RELEASE; COST EFFECTIVENESS ANALYSIS; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; MUSCULOSKELETAL DISEASE; PRIORITY JOURNAL; ARTICLE; BIOLOGICAL MODEL; HUMAN; IMMUNOLOGY; IN VITRO STUDY; METHODOLOGY; OSTEOMYELITIS; REPRODUCIBILITY; TIME;

AMIKACIN; ANTI-BACTERIAL AGENTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GENTAMICINS; HUMANS; MODELS, IMMUNOLOGICAL; OSTEOMYELITIS; POLYMETHYL METHACRYLATE; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TOBRAMYCIN; VANCOMYCIN; VASODILATOR AGENTS;

EID: 0036793473     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-200210000-00009     Document Type: Conference Paper

References (14)

1. Benoit MA, Mousset B, Delloye C, Bouillet R, Gillard J: Antibiotic-loaded plaster of paris implants coated with poly lactide-co-glycolide as a controlled release delivery system for the treatment of bone infections. Int Orthop 21:403-408, 1997.
2. Calhoun JH, Mader JT: Antibiotic beads in the management of surgical infections. Am J Surg 157:443-449, 1989.
3. Calhoun JH, Mader JT: Treatment of osteomyelitis with a biodegradable antibiotic implant. Clin Orthop 341:206-214, 1997.
4. Dash AK, Suryanarayanan R: Comparison of the release kinetics of tobramycin from polymethylmethacrylate (PMMA) and polydimethylsiloxane (PDMS) beads. Pharm Res 8(Suppl):135, 1991. Abstract.
5. Goodell JA, Flick AB, Hebert JC, Howe JG: Preparation and release characteristics of tobramycin-impregnated polymethylmethacrylate beads. Am J Hosp Pharm 43:1454-1461, 1986.
6. Lin SS, Ueng SWN, Liu SJ, et al: Development of a biodegradable antibiotic delivery system. Clin Orthop 362:240-250, 1999.
7. Liu SJ, Ueng SWN, Chan EC, et al: In vitro elution of vancomycin from biodegradable beads. J Biomed Mater Res 48:613-620, 1999.
8. Mader JT, Calhoun J, Cobos J: In vitro evaluation of antibiotic diffusion from antibiotic-impregnated biodegradable beads and polymethylmethacrylate beads. Antimicrob Agents Chemother 41:415-418, 1997.
9. Masri BA, Duncan CP, Beauchamp CP: Long-term elution of antibiotics from bone cement. J Arthroplasty 13:331-338, 1998.
10. Picknell B, Mizen L, Sutherland R: Antibacterial activity of antibiotics in acrylic bone cement. J Bone Joint Surg 59B:302-307, 1997.
11. Salvati EA, Callaghan JJ, Brause BD, Klein RF, Small RD: Reimplantation in infection: Elution of gentamicin from cement and beads. Clin Orthop 207:83-93, 1986.
12. Wahlig H, Dingeldein E: Antibiotics and bone cement. Acta Orthop Scand 51:49-56, 1980.
13. Wahlig H, Dingeldein E, Bergmann R, Reuss K: The release of gentamicin from polymethylmethacrylate beads. J Bone Joint Surg 60B:270-275, 1976.
14. Wilson KJ, Cierny G, Adams KR, Mader JT: Comparative evaluation of the diffusion of tobramycin and cefotaxime out of antibiotic-impregnated polymethylmethacrylate beads. J Orthop Res 6:279-286, 1988.