Positive experimental demonstration of the negative brain "protective" effects of anesthetics following cardiac arrest

Anesthesiology

Volumn 97, Issue 4, 2002, Pages 1005-1006

  Michenfelder, John D ^a   Raja, Srinivasa N ^a  

^a NONE

Author keywords

Anesthetics, intravenous: thiopental; Brain: metabolism; Metabolism: brain

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANESTHETIC AGENT; CREATINE PHOSPHATE; GLUCOSE; HALOTHANE; LACTIC ACID; PYRUVIC ACID; THIOPENTAL;

ANIMAL EXPERIMENT; BRAIN FUNCTION; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; BRAIN PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GLUCOSE BRAIN LEVEL; HEART ARREST; HYPOXIA; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0036792370     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200210000-00036     Document Type: Short Survey

References (7)

1. Michenfelder, JD: The interdependency of cerebral functional and metabolic effects following massive doses of thiopental in the dog. Anesthesiology 1974; 41:231-6
2. Michenfelder, JD, Theye RA: The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation. Anesthesiology 1970; 33:430-9
3. Michenfelder JD, Messick JM Jr, Theye RA: Simultaneous cerebral blood flow measured by direct and indirect methods. J Surg Res 1968; 8:475-81
4. Kety SS: Discussion. Pharmacol Rev 1965; 17:230-2
5. Brain Resuscitation Study Group: Randomized survivors of cardiac arrest. N Engl J Med 1986; 314:397-4035
6. Michenfelder, JD, Theye RA: In vivo toxic effects of halothane on canine cerebral metabolic pathways. Am J Physiol 1975; 229:1050-5
7. Newberg LA, Milde JH, Michenfelder JD: The cerebral metabolic effects of isoflurane at and above concentrations that suppress cortical electrical activity. Anesthesiology 1983; 59:23-8