A polydisperse aerosol inhalation system designed for human studies

Journal of Aerosol Science

Volumn 33, Issue 10, 2002, Pages 1433-1446

  Rosati, Jacky A ^a   Brown, James S ^b   Peters, Thomas M ^a   Leith, David ^a   Kim, Chong S ^c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c US Environmental Protection Agency/National Health Effects Research Laboratory   (United States)

Author keywords

Deposition; Inhalation; Polydisperse aerosol

Indexed keywords

COMPUTER SIMULATION; DEPOSITION; SCANNING; VALVES (MECHANICAL);

INHALATION SYSTEMS;

AEROSOLS;

AEROSOL;

AEROSOL; ARTICLE; CONTROLLED STUDY; DEVICE; DISPERSION; GEOMETRY; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; NEBULIZER; NORMAL HUMAN; PARTICLE SIZE; PNEUMOTACHYGRAPHY; PRIORITY JOURNAL; VALIDATION PROCESS;

EID: 0036790906     PISSN: 00218502     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-8502(02)00087-3     Document Type: Article

References (15)

1. Davies C.N., Heyder J., Subba Ramu M.C. Breathing of half-micron aerosols I. Experimental. Journal of Applied Physiology. 32:1972;591-600.
2. Diu C.K., Yu C.P. Respiratory tract deposition of polydisperse aerosols in humans. American Industrial Hygiene Association Journal. 44:1983;62-65.
3. Dockery D.W., Pope C.A. III. Acute respiratory effects of particulate air pollution. Annual Review of Public Health. 15:1994;107-132.
4. Dockery D.W., Pope C.A.III., XU C., Spengler J.D., Ware J.H., Fay M.E., Ferris B.G., Speizer F.E. An association between air pollution and mortality in six U.S. cities. New England Journal of Medicine. 329:1993;1753-1759.
5. Ferron G.A., Karg E., Peter J.E. Estimation of deposition of polydisperse hygroscopic aerosols in the human respiratory tract. Journal of Aerosol Science. 24:1993;655-670.
6. Heyder J., Gebhart J., Heigwer G., Roth C., Stahlhofen W. Experimental studies of the total deposition of aerosol particles in the human respiratory tract. Journal of Aerosol Science. 4:1973;191-208.
7. James, A. C., Jarabek, A. M., Morrow, P., Schlesinger, R. B., Snipes, M. B., & Yu, C. P. (1996). Dosimetry of inhaled particle in the respiratory tract. USEPA, Air Quality Criteria Document for Particulate Matter.
8. John W. The characteristics of environmental and laboratory-generated aerosols. Willeke K., Baron P.A. Aerosol measurement: Principles, techniques, and applications. 1993;Van Nostrand Reinhold, New York.
9. Kim C.S., Hu S.C. Regional deposition of inhaled particles in human lungs. comparison between men and women Journal of Applied Physiology. 84:1998;1834-1844.
10. Kim C.S., Hu S.C., DeWitt P., Gerrity T.R. Assessment of regional deposition of inhaled particles in human lungs by serial bolus delivery method. Journal of Applied Physiology. 81:1996;2203-2213.
11. MacNee W., Donaldson K. Particulate air pollution: Injurious and protective mechanisms in the lungs, air pollution and health. Holgate S.T., Koren H.S., Maynard R.L., Samet J.M. Air pollution and health. 1999;Academic Press, New York.
12. Utell M.J., Frampton M.W. Particles and mortality. A clinical perspective Inhalation Toxicology. 7:1995;645-655.
13. Wanner A., Brodnan J.M., Perez J., Henke K.G., Kim C.S. Variability of airway responsiveness to histamine aerosol in normal subjects. American Review of Respiratory Disease. 131:1985;3-7.
14. Wark K., Warner C.F. Air pollution: Its origin and control. 1981;Harper Collins, New York.
15. Wilson F.J., Hiller F.C., Wilson J.D., Bone R.C. Quantitative deposition of ultrafine stable particles in the human respiratory tract. Journal of Applied Physiology. 58:1985;223-229.