Recovery from infectious mononucleosis: A case for more than symptomatic therapy? A systematic review

British Journal of General Practice

Volumn 52, Issue 483, 2002, Pages 844-851

  Candy, Bridget ^a   Chalder, Trudie ^a   Cleare, Anthony J ^a   Wessely, Simon ^a   White, Peter D ^a   Hotopf, Matthew ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Chronicity; Infectious mononucleosis; Recovery rate; Systematic review

Indexed keywords

ACICLOVIR; PREDNISOLONE;

BED REST; CHRONIC DISEASE; CHRONIC FATIGUE SYNDROME; CHRONICITY; CLINICAL FEATURE; CLINICAL TRIAL; COHORT ANALYSIS; CONVALESCENCE; DATA BASE; DISEASE COURSE; DRUG EFFECT; EMBASE; EPSTEIN BARR VIRUS; FEVER; HUMAN; INFECTIOUS MONONUCLEOSIS; LYMPHADENOPATHY; MEDLINE; MENTAL DISEASE; NONHUMAN; OUTCOMES RESEARCH; PHARYNGITIS; PREDICTION; PREVENTIVE MEDICINE; PRIMARY MEDICAL CARE; PROGNOSIS; PSYCHOLOGICAL ASPECT; REVIEW; RISK FACTOR; SOCIAL PSYCHOLOGY; SYMPTOM;

CHRONIC DISEASE; FATIGUE SYNDROME, CHRONIC; HUMANS; INFECTIOUS MONONUCLEOSIS; PROGNOSIS; RISK FACTORS;

EID: 0036790434     PISSN: 09601643     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (53)

1. Halle TJ, Evans AS, Niederman JC, et al. Infectious mononucleosis at the United States military academy. Yale J Biol Med 1974; 47: 182-195.
2. Evans AS, Robinton ED. An epidemiological study of infectious mononucleosis. N Engl J Med 1950; 242: 492-496.
3. Niederman JC, Evans AS, Subrahmanyan L, McCollum RW. Prevalence, incidence and persistence of EB virus antibody in young adults. N Engl J Med 1970; 282: 361-364.
4. Sawyer RN, Evans AS, Niederman JC, McCollum RW. Prospective studies of a group of Yale University freshmen. 1. Occurrence of infectious mononucleosis. J Infect Dis 1971; 123: 263-270.
5. Issacs R. Chronic infectious mononucleosis. Blood 1948; 3:858-861.
6. Dalrymple W. Infectious mononucleosis - 2. Relation of bed rest and activity to prognosis. Postgrad Med J 1964; 35: 345-349.
7. Thompson DS, Godleski J, Herman S. Prognosis post infectious mononucleosis. J Am Coll Health 1969; 17: 453-457.
8. Chretien J, Esswein J, Holland W, McCauley C. Predictors of the duration of infectious mononucleosis. South Med J 1977; 70: 437-439.
9. Horwitz CA, Henle W, Henle G, Schmitz H. Clinical evaluation of patients with infectious mononucleosis and development of antibodies to the R component of the Epstein-Barr virus after recovery from infectious mononucleosis. J Infect 1985; 151: 1150-1153.
10. Salit IE. Sporadic post-infectious neuromyasthenia. Can Med Assoc J 1985; 133: 659-663.
11. Straus SE, Tosato G, Armstrong G, et al. Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. Ann Intern Med 1985; 102: 7-16.
12. Borysiewicz LK, Haworth SJ, Cohen J, et al. Epstein-Barr virus-specific immune defects in patients with persistent symptoms following infectious mononucleosis. QJM 1986; 58: 111-121.
13. Lambore S, McSherry J, Kraus AS. Acute and chronic symptoms of mononucleosis. J Fam Pract 1991; 33: 33-37.
14. White PD, Thomas J, Amess J, et al. Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever. Br J Psychiatry 1998; 173: 475-481.
15. White PD, Grover SA, Kangro HO, et al. The existence of a fatigue syndrome after glandular fever. Psychol Med 1995; 25: 907-916.
16. White PD, Thomas JM, Kangro H, et al. Predictions and associations of fatigue syndromes and mood disorders that occur after infectious mononucleosis. Lancet 2001; 358: 1946-1954.
17. Buchwald DS, Rea TD, Katon WJ, et al. Acute infectious mononucleosis: characteristics of patients who report failure to recover. Am J Med 2000; 109: 531-537.
18. Rea TD, Russo JE, Katon W, Buchwald D. Prospective study of the natural history of infectious mononucleosis caused by Epstein-Barr virus. J Am Board Fam Pract 2001; 14: 234-242.
19. Torre D, Tambini R. Acyclovir for treatment of infectious mononucleosis: a meta-analysis. Scand J Infect Dis 1999; 31: 543-547.
20. Keller MS, Troy S. Nasopharyngeal obstruction in infectious mononucleosis. Am Fam Physician 1987; 35: 205-209.
21. Maki D, Reich R. Infectious mononucleosis in the athlete. Diagnosis, complications and management. Am J Sports Med 1982; 10: 162-173.
22. Eichner ER. Infectious mononucleosis-recognising the condition, 'reactivating' the patient. Physician Sports Med 1996; 24: 49-54.
23. Hickey SM, Strasburger VC. What every paediatrician should know about infectious mononucleosis in adolescents. Adolesc Med 1997; 44: 1541-1556.
24. Peter J, Ray G. Infectious mononucleosis. Pediatr Rev 1998; 19: 276-279.
25. American Academy of Family Physicians. URL: www.familydoctor.org/handouts/077.html. Accessed 30 March 2001.
26. Cohen JI. Epstein-Barr virus infections, including infectious mononucleosis. In: Braunwald E, Fauci AS, Kasper DL, et al (eds). Harrison's Principles of Internal Medicine. 15th Edition. New York: McGraw Hill, 2001
27. Godshall SE, Kirchner JT. Infectious mononucleosis. Postgrad Med 2001; 107: 175-186.
28. Kief E. Chapter 387. In: Cecil RL, Goldman L, Bennett JC (eds). Cecil Textbook of Medicine. 21st Edition. New York: WB Saunders Company, 2000.
29. Colquhoun J. The glandular fever virus. Aust Fam Physician 1985; 14: 380.
30. Dickinson MB. Glandular fever: a personal clinical view. Practitioner 1982; 226: 1491-1494.
31. Epstein MA, Crawford DH. The Epstein-Barr Virus. In: Weatherall DJ, Ledigham JGG, Warrell DA (eds). The Concise Oxford Textbook of Medicine. Oxford University Press, 2000.
32. Andersson J, Skoldenberg B, Henle W, et al. Acyclovir treatment in infectious mononucleosis: a clinical and virological study. Infection 1987; 15 (supp 1): S14-20.
33. Tynell E, Aurelius E, Brandell A, et al. Acyclovir and prednisolone treatment of acute infectious mononucleosis: a multicenter, double-blind, placebo-controlled study. J Infect Dis 1996; 174: 324-331.
34. Bruce-Jones WDA, White PD, Thomas JM, Clare AW. The effect of social adversity on the fatigue syndrome, psychiatric disorders and physical recovery, following glandular fever. Psychol Med 1994; 24: 651-659.
35. Katon W, Russo J, Ashley RL, Buchwald D. Infectious mononucleosis: psychological symptoms during acute and subacute phases of illness. Gen Hosp Psychiatry 1999; 21: 21-29.
36. Chang RS, Bittner W. Chronic fatigue syndrome. JAMA 1991; 265: 357.
37. Greenfield N, Roessler R, Crosley A. Ego strength and length of recovery from infectious mononucleosis. J Nerv Ment Dis 1959; 128: 125-128.
38. Cadie M, Nye FJ, Storey P. Anxiety and depression after infectious mononucleosis. Br J Psychiatry 1976; 128: 559-561.
39. Wessely S, Chalder T, Hirsch S, et al. The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care study. Am J Public Health 1997; 9: 1449-1455.
40. Nye FG. Social class and infectious mononucleosis. J Hyg (Lond) 1973; 71: 145-149.
41. Henkle CE, Kurland LT, Elveback LR. Infectious mononucleosis in Rochester, NY, 1950 through 1969. Am J Epidemiol 1973; 98: 483.
42. Little P, Gould C, Williamson I, et al. Clinical and psychosocial predictors of illness duration from a randomised controlled trial of prescribing strategies for sore throat. BMJ 1999; 319: 736-737.
43. Cope H, David A, Pelosi A, Mann A. Predictors of chronic 'postviral' fatigue. Lancet 1996; 344: 864-868.
44. Sharpe M, Hawton K, Seagroat V, Pasvol G. Follow-up of patients presenting with fatigue to an infectious clinic. BMJ 1992; 305: 147-152.
45. Rose M, Scholler G, Jorres A, et al. Patients' expression of complaints as a predictor of the course of acute hepatitis A. J Psychosom Res 2000; 48: 107-113.
46. Hotopf M, Noah N, Wessely S. Chronic fatigue and minor psychiatric morbidity after viral meningitis: a controlled study. J Neurol Neurosurg Psychiatry 1996; 60: 504-509.
47. Waddell G, Feder G, Lewis M. Systematic reviews of bed rest and advice to stay active for acute low back pain. Br J Gen Pract 1997; 47: 647-652.
48. Allen C, Glasziou P, Del Mar C. Bed rest: a potentially harmful treatment needing more careful evaluation. Lancet 1999; 354: 1229-1233.
49. Repsher LH, Freeburn RK. Effects of early and vigorous exercise on recovery from infectious hepatitis. N Engl J Med 1969; 281: 1393-1396.
50. Chalder T, Wallace P, Wessely S. Self-help treatment of chronic fatigue in the community: A randomised controlled trial. Br J Health Psychol 1997; 2: 189-197.
51. Powell P, Bentall R, Nye FJ, Edwards RHT. Randomised controlled trial of patient education to encourage graded exercise in chronic fatigue syndrome. BMJ 2001; 322: 387.
52. Prins J, Bleijenberg G, Bazelmans E, et al. Cognitive behaviour therapy for chronic fatigue syndrome: a multi-center randomised controlled trial. Lancet 2001; 358: 238.
53. Waddell G, McIntosh A, Hutchinson A, et al. Low back pain evidence review. London: Royal College of General Practitioners, 1999.