Differential effect of cytotoxic T lymphocyte variant epitopes on generation and cytotoxicity in chronic hepatitis C virus infection

Hepatology Research

Volumn 24, Issue 2, 2002, Pages 91-94

  Hiroishi, Kazumasa ^a   Eguchi, Jun Ichi ^a   Ishii, Shigeaki ^a   Okamoto, Hiroaki ^b   Mitamura, Keiji ^a   Imawari, Michio ^b  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Cytotoxic T lymphocyte; Hepatitis C virus; HLA B44; Variant epitope

Indexed keywords

AMINO ACID; CD45 ANTIGEN; EPITOPE; HLA B ANTIGEN; VIRUS NUCLEOPROTEIN;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENE LOCUS; GENETIC VARIABILITY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOCYTOTOXICITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 0036788960     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(02)00078-5     Document Type: Article

References (11)

1. Yap KL, Ada GL, McKenzie IFC. Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature 1978;273:238-9.
2. Zinkernagel RM, Haenseler E, Leist T, Cerny A, Hengartner H, Althage A. T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay? J Exp Med 1986;164:1075-92.
3. Kita H, Hiroishi K, Moriyama T, et al. A minimal and optimal cytotoxic T-cell epitope within hepatitis C virus nucleoprotein. J Gen Virol 1995;76:3189-93.
4. Kita H, Moriyama T, Kaneko T, et al. HLA B44-restricted cytotoxic T Lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein. Hepatology 1993;18:1039-44.
5. Hiroishi K, Kita H, Kojima M, et al. Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection. Hepatology 1997;25:705-12.
6. Weiner AJ, Christopherson C, Hall JE, et al. Sequence variation in hepatitis C viral isolates. J Hepatol 1991;13(Suppl. 4):S6-S14.
7. Chang K-M, Rehermann B, McHutchison JG, et al. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J Clin Invest 1997;100:2376-85.
8. Hölberg P, Weber W, Dangond F, Batra V, Sette A, Hafler D. Differential activation of proliferation and cytotoxicity in human T-cell lmphotrophic virusi type I Tax-specific CD8 T cells by an altered peptide ligand. Proc Natl Acad Sci USA 1995;92:4036-40.
9. Klenerman P, Meier U-C, Phillips R, McMichael A. The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus. Eur J Immunol 1995;25:1927-31.
10. McAdam S, Klenerman P, Tussey L, et al. Immunogenic HIV variant peptides that bind to HLA-B8 can fail to stimulate cytotoxic T lymphocyte responses. J Immunol 1995;155:2729-36.
11. Kaneko T, Moriyama T, Hiroishi K, et al. Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope. Eur J Immunol 1997;27:1782-7.