No association between obsessive-compulsive disorder and the 5-HT1Dβ receptor gene

American Journal of Psychiatry

Volumn 159, Issue 10, 2002, Pages 1783-1785

  Di Bella, Daniela ^a   Cavallini, Maria Cristina ^a   Bellodi, Laura ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR SUBTYPE; SEROTONIN 1D BETA RECEPTOR; SEROTONIN 1D RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; COMPULSION; FAMILY HISTORY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; OBSESSION; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR GENE; SEROTONINERGIC SYSTEM;

ADULT; AGE OF ONSET; FAMILY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; ITALY; LINKAGE DISEQUILIBRIUM; MALE; OBSESSIVE-COMPULSIVE DISORDER; POLYMORPHISM, GENETIC; RECEPTORS, SEROTONIN;

EID: 0036787459     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.159.10.1783     Document Type: Article

References (14)

1. Sasson Y, Amiatz R, Chopra M, Nakash N, Zohar J: Treatment approaches to OCD-the role of serotonin, in The Basal-Cortical Function in Obsessive Compulsive Disorder Spectrum. Edited by Bellodi L, Cavallaro R. Pisa, Italy, Pacini Editore, 2000, pp 213-230
2. McDougle CJ, Epperson CN, Price LH, Gelernter J: Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Mol Psychiatry 1998; 3:270-273
3. Bengel D, Greenberg B, Cora-Locatelli G, Altemus M, Heils A, Li Q, Murphy D: Association of the serotonin transporter promoter regulatory-region polymorphism and obsessive-compulsive disorder. Mol Psychiatry 1999; 4:463-466
4. Enoch MA, Kaye WH, Rotondo A, Greenberg BD, Murphy DL, Goldman D: 5-HT2A promoter polymorphism - 1438G/A, anorexia nervosa, and obsessive-compulsive disorder. Lancet 1998; 351:1785-1786
5. Stern L, Zohar J, Cohen R, Sasson Y: Treatment of severe, drug resistant obsessive compulsive disorder with the 5HT1D agonist sumatriptan. Eur Neuropsychopharmacol 1998; 8:325-328
6. Koran LM, Pallanti S, Quercioli L: Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder. Eur Neuropsychopharmacol 2001; 11:169-172
7. 1Dβ receptor gene implicated in the pathogenesis of obsessive-compulsive disorder? Am J Psychiatry 2000; 157:1160-1161
8. Lappalainen J, Dean M, Charbonneau L, Virkkunen M, Linnoila M, Goldman D: Mapping of the serotonin 5-HT1D beta autoreceptor gene on chromosome 6 and direct analysis for sequence variants. Am J Med Genet 1995; 60:157-161
9. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS: The Yale-Brown Obsessive Compulsive Scale, I: development, use, and reliability. Arch Gen Psychiatry 1989; 46:1006-1011
10. Lahiri DK, Nurnberger JI Jr: A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 1991; 19:5444
11. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52:506-516
12. Spielman RS, Ewens WJ: A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet 1998; 62:450-458
13. Knapp M: A note on power approximations for the transmission/disequilibrium test. Am J Hum Genet 1999; 64:1177-1185
14. 1D function and repetitive behaviors (letter). Am J Psychiatry 2001; 158:972-973