In vivo characterization of the mitochondrial selective kATP opener (3R)-trans-4-((4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl) dimethyl-2H-1-benzopyran-6-carbonitril monohydrochloride (BMS-191095): Cardioprotective, hemodynamic, and electrophysiological effects

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 1, 2002, Pages 132-140

  Grover, Gary J ^a   D'Alonzo, Albert J ^a   Darbenzio, Raymond B ^a   Parham, Charles S ^a   Hess, Thomas A ^a   Bathala, Mohinder S ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(4 CHLOROPHENYL) N (1H IMIDAZOL 2 YLMETHYL)]DIMETHYL 2H 1 BENZOPYRAN 6 CARBONITRILE; ADENOSINE TRIPHOSPHATE; BMS 191095; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CORONARY HEMODYNAMICS; DOG; DOSE RESPONSE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG TOLERABILITY; ELECTROSTIMULATION; FEMALE; HEART ELECTROPHYSIOLOGY; HEART INFARCTION SIZE; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART STIMULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SARCOLEMMA;

ANIMALS; ARRHYTHMIA; BENZOPYRANS; BLOOD PRESSURE; CARDIOTONIC AGENTS; CORONARY VESSELS; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; HEMODYNAMIC PROCESSES; IMIDAZOLES; ION CHANNEL GATING; MALE; MEMBRANE PROTEINS; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; POTASSIUM CHANNELS;

EID: 0036785526     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.036988     Document Type: Article

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