Levofloxacin and warfarin interaction

Annals of Pharmacotherapy

Volumn 36, Issue 10, 2002, Pages 1554-1557

  Jones, Cade B ^a   Fugate, Susan E ^a   Mena, Rafaela ^a   Robert, Sylvie ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Drug interaction; Fluoroquinolones; Levofloxacin; Quinolones; Warfarin

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; DIPYRIDAMOLE; LEVOFLOXACIN; PROTHROMBIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VITAMIN K GROUP; WARFARIN;

ADULT; AGED; ANTIBIOTIC THERAPY; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; CASE REPORT; DRUG METABOLISM; DRUG MONITORING; DRUG PROTEIN BINDING; FEMALE; HUMAN; INTERNATIONAL STANDARD UNIT; INTESTINE FLORA; LONG TERM CARE; MALE; PRIORITY JOURNAL;

EID: 0036785188     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1C074     Document Type: Article

References (25)

1. Borcherding SM, Stevens R, Nicholas RA, Corley CR, Self T. Quinolones: a practical review of clinical uses, dosing considerations, and drug interactions. J Fam Pract 1996;42:69-78.
2. Fish DN, Chow AT. The clinical pharmacokinetics of levofloxacin. Clin Pharmacokinet 1997;32:101-19.
3. Hirsh J, Dalen JE, Anderson DR, Poller L, Bussey H, Ansell J, et al. Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 2001;119(suppl 1):8S-21S.
4. Wells PS, Holbrook AM, Crowther NR, Hirsh J. Interactions of warfarin with drugs and food. Ann Intern Med 1994; 121:676-83.
5. Byrd DC, Gaskins SE, Parrish AM, Freeman LB. Warfarin and ciprofloxacin interaction: case report and controversy. J Am Board Fam Pract 1999; 12:486-8.
6. Bianco TM, Bussey HI, Farnett LE, Linn WD, Roush MK, Wong TW. Potential warfarin-ciprofloxacin interaction in patients receiving long-term anticoagulation. Pharmacotherapy 1992;12:435-9.
7. Renzi R, Finkbeiner S. Ciprofloxacin interaction with sodium warfarin: a potentially dangerous side effect. Am J Emerg Med 1991;9:551-2.
8. Leor J, Matetzki S. Ofloxacin and warfarin (letter). Ann Intern Med 1988;109:761.
9. Toon S, Hopkins JK, Garstang FM, Aarons L, Sedman A, Rowland M. Enoxacin-warfarin interaction: pharmacokinetic and stereochemical aspects. Clin Pharmacol Ther 1987;42:33-41.
10. Jolson HM, Tanner LA, Green L, Grasela TH. Adverse reaction reporting of interaction between warfarin and fluoroquinolones. Arch Intern Med 1991;151:1003-4.
11. Mott FE, Murphy S, Hunt V. Ciprofloxacin and warfarin (letter). Ann Intern Med 1989;111:542-3.
12. Linville D, Emory C, Graves L. Ciprofloxacin and warfarin interaction (letter). Am J Med 1991;90:765.
13. Kamada AK. Possible interaction between ciprofloxacin and warfarin. DICP 1990;24:27-8.
14. Johnson KC, Joe RH, Self TH. Drug interaction (letter). J Fam Pract 1991;33:338.
15. Leor J, Levartowsky D, Sharon C. Interaction between nalidixic acid and warfarin (letter). Ann Intern Med 1987;107:601.
16. Linville T, Matanin D. Norfloxacin and warfarin (letter). Ann Intern Med 1989;110:751-2.
17. Baciewicz AM, Ashar BH, Locke TW. Interaction of ofloxacin and warfarin (letter). Ann Intern Med 1993;119:1223.
18. Liao S, Palmer M, Fowler C, Nayak RK. Absence of an effect of levofloxacin on warfarin pharmacokinetics and anticoagulation in male volunteers. J Clin Pharmacol 1996;36:1072-7.
19. Ravnan SL, Locke C. Levofloxacin and warfarin interaction. Pharmacotherapy 2001;21:884-5.
20. Gheno G, Cinetto L. Levofloxacin-warfarin interaction (letter). Eur J Clin Pharmacol 2001;57:427.
21. Ansell J, Hirsh J, Dalen J, Bussey H, Anderson D, Poller L, et al. Managing oral anticoagulant therapy. Chest 2001;119(suppl 1):22S-38S.
22. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method of estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.
23. Lipsky JJ. Antibiotic-associated hypothrombinaemia. J Antimicrob Chemother 1988;21:281-300.
24. Colucci VJ, Rivey MP. Tolterodine-warfarin drug interaction. Ann Pharmacother 1999;33:1173-6.
25. Richards RK. Influence of fever upon the action of 3,3-methylene bis-(4-hydroxycoumarin). Science 1943;97:313-6.