A practical procedure for the synthesis of esonarimod, (R,S)-2- acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid, an antirheumatic agent (Part 1)

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 10, 2002, Pages 1407-1412

  Noguchi, Toshiya ^a   Onodera, Akira ^a   Tomisawa, Kazuyuki ^a   Yokomori, Sadakazu ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antirheumatic drug; Esonarimod; Friedel Crafts acylation; Michael addition; Process chemistry

Indexed keywords

ACID ANHYDRIDE; ALUMINUM DERIVATIVE; ANTIRHEUMATIC AGENT; BUTYRIC ACID DERIVATIVE; ESONARIMOD; NITROBENZENE; SILICA GEL; THIOACETIC ACID; TOLUENE; 2-ACETYLTHIOMETHYL-3-(4-METHYLBENZOYL)PROPIONIC ACID; PHENYLPROPIONIC ACID DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; INFRARED SPECTROSCOPY; MICHAEL ADDITION; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; STRUCTURE ANALYSIS; CHEMISTRY; SYNTHESIS;

ANTIRHEUMATIC AGENTS; PHENYLPROPIONATES;

EID: 0036782999     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1407     Document Type: Article

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