Metabolism of a new neuroprotective agent for ischemia-reperfusion damage, KR-31543 in the rats using liquid chromatography/electrospray mass spectrometry

Archives of Pharmacal Research

Volumn 25, Issue 5, 2002, Pages 664-668

  Kim, John ^a,e   Hye, Young Ji ^b   Lee, Seung Seok ^b   Yoo, Sung Eun ^c   Sun, Ok Kim ^d   Dong, Ha Lee ^d   Lim, Hong ^d   Hye, Suk Lee ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Wonkwang University   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

^d Dongbu Hannong Chemical Co   (South Korea)

^e LG Chemical Ltd   (South Korea)

Author keywords

CYP; KR 31543; LC MS MS; Metabolism; Neuroprotective

Indexed keywords

BENZOPYRAN DERIVATIVE; CYP3A1 PROTEIN, RAT; KR 31543; KR-31543; NEUROPROTECTIVE AGENT; TETRAZOLE DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; METABOLISM; METHODOLOGY; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZOPYRANS; CHROMATOGRAPHY, LIQUID; MALE; MICROSOMES, LIVER; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TETRAZOLES;

EID: 0036782245     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02976941     Document Type: Article

References (3)

1. De Keyser J, Sulter G, Luiten PG. Clinical trials with neuroprotective drugs in acute ischemia stroke: are we doing the right thing? Trends Neurosci., 22, 535-540 (1999).
2. Hong, K.W., Kim, K.Y., Lee, J. H., Shin, H. K., Kwak, Y. G., Kim, S. O., Lim, H. and Yoo, S. E., Neuroprotective effect of (2S,3S,4R)-N″-cyano-N- (6-amino-3, 4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)- N′-benzylguanidine (KR-31378), a benzopyran analog, against focal ischemic brain damage in rats. J. Pharmacol. Exp. Ther., 301, 210-216 (2002).
3. Yoo, S. E., Yi, K. Y., Lee, S., Suh, J., Kim, N., Lee, B. H., Seo, H. W., Kim, S. O., Lee, D. H., Lim, H. and Shin, H. S., A novel anti-ischemic ATP-sensitive potassium channel opener without vasorelaxation: N-(6-aminobenzopyranyl)-N′-benzyl-N″-cyanoguanidine analogue. J. Med. Chem., 44, 4207-4215 (2001).