Penetration of Topically Administered Ofloxacin and Trimethoprim into Aqueous Humor

Journal of Ocular Pharmacology and Therapeutics

Volumn 18, Issue 5, 2002, Pages 445-453

  Price, Francis W ^a   Dobbins, Kendall ^a   Zeh, William ^a  

^a Cornea Research Foundation ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OFLOXACIN; POLYTRIM; EYE DROPS; TOPICAL ANTIINFECTIVE AGENT; TRIMETHOPRIM;

ADULT; AGED; ANTIBACTERIAL ACTIVITY; AQUEOUS HUMOR; ARTICLE; CATARACT EXTRACTION; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONJUNCTIVITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PREOPERATIVE CARE; PSEUDOMONAS AERUGINOSA; RANDOMIZED CONTROLLED TRIAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOCOCCUS PNEUMONIAE; DRUG INSTILLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MIDDLE AGED; PERMEABILITY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS, LOCAL; AQUEOUS HUMOR; CATARACT EXTRACTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; INSTILLATION, DRUG; MALE; MASS SPECTROMETRY; MIDDLE AGED; OFLOXACIN; OPHTHALMIC SOLUTIONS; PERMEABILITY; TRIMETHOPRIM;

EID: 0036781375     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/10807680260362722     Document Type: Article

References (25)

1. Wagner, R.S. Results of a survey of children with acute bacterial conjunctivitis treated with trimethoprim-polymyxin B ophthalmic solution. Clin. Ther. 17:875-881, 1995.
2. Wallace, D.K., and Steinkuller, P.G. Ocular medications in children. Clin. Pediatr. 37:645-652, 1998.
3. Foulks, G.N., Gordon, J.S., and Kowalski, R.P. Bacterial infections of the conjunctiva and cornea. In Principles and Practice of Ophthalmology, 2nd ed., Albert D.M., Jakobiec F.A., Azar D.T., Graroudas E.S., eds. W.B. Saunders, Philadelphia, PA, 2000, pp.893-905.
4. Osher, R.H., Amdahl, L.D., and Cheetham, J.K. Antimicrobial efficacy and aqueous humor concentration of preoperative and post-operative topical trimethoprim/polymyxin B sulfate versus tobramycin. J. Cataract Refract. Surg. 20:3-8, 1994.
5. Wise, R., Andrews, J.M., Ashby, J.P., and Matthews, R.S. In vitro activity of lomefloxacin, a new quinolone antimicrobial agent, in comparison with those of other agents. Antimicrobiol. Agents Chemother. 32:617-622, 1988.
6. Beck, R., van Keyserlingk, J., Fischer, U., Guthoff, R., and Drewelow, B. Penetration of ciprofloxacin, norfloxacin, and ofloxacin into the aqueous humor using different topical application modes. Graefe's Arch. Clin. Exp. Ophthalmol. 237:89-92, 1999.
7. Cekic, O., Batman, C., Totan, Y., Yasar, U., Basci, N.E., Bozkurt, A., Kayaalp, S.O., and Zilelioglu, O. Aqueous humor levels of topically applied ciprofloxacin and ofloxacin in the same subjects. Eye. 13:656-659, 1999.
8. Diamond, J.P., White, L., Leeming, J.P., Hoh, H.B., and Easty, D.L. Topical 0.3% ciprofloxacin, norfloxacin, and ofloxacin in treatment of bacterial keratitis: a new method for comparative evaluation of ocular drug penetration. Br. J. Ophthalmol. 79:606-609, 1995.
9. Cantor, L.B., Donnenfeld, E.D., Katz, L.J., Gee, W.L., Finley, C.D., Lakhani, V.K., Hoop, J., and Flarty, K. Penetration of ofloxacin and ciprofloxacin into the aqueous of eyes with functioning filtering blebs: a randomized trial. Arch. Ophthalmol., in press.
10. Basci, N.E., Hanioglu-Kargi, S., Soysal, H., Bozkurt, A., and Kayaalp, S.O. Determination of ofloxacin in human aqueous humor by high-performance liquid chromatography with fluorescence detection. J. Pharm. Biomed. Anal. 15:663-666, 1997.
11. Donnenfeld, E.D., Perry, H.D., Snyder, R.W., Moadel, K., Elsky, M., and Jones, H. Intracorneal, aqueous humor, and vitreous humor penetration of topical and oral ofloxacin. Arch. Ophthalmol. 115:173-176, 1997.
12. Borrmann, L., Tang-Liu, D.D.-S., Kann, J., Nista, J., Lin, E.T., and Frank, J. Ofloxacin in human serum, urine, and tear film after topical application. Cornea 11:226-230, 1992.
13. Richman, J., Zolezio, H., and Tang-Liu, D. Comparison of ofloxacin, gentamicin, and tobramycin concentrations in tears and in vitro MICs for 90% of test organisms. Antimicrob. Agents and Chemother. 34:1602-1604, 1990.
14. Tang-Liu, D.D.-S., Schwob, D.L., Ussansky, J.I., and Gordon, Y.J. Comparative tear concentrations over time of ofloxacin and tobramycin in human eyes. Clin. Pharmacol. Ther. 55:284-292, 1994.
15. Osato, M.S., Jensen, H.G., Trousdale, M.D., Bosso, J.A., Borrmann, L.R., Frank, J., and Akers, P. The comparative in vitro activity of ofloxacin and selected ophthalmic antimicrobial agents against ocular bacterial isolates. Am. J. Ophthalmol. 108:380-386, 1989.
16. Osato, M.S., Jensen, H.G., Trousdale, M.D., and Bosso, J.A. The comparative in vitro activity of ofloxacin and selected ophthalmic antimicrobial agents against ocular bacterial isolates-correction. Am. J. Ophthalmol. 112:478-479, 1991.
17. Price, F.W., Whitson, W.E., Gonzales, J., and Johns, S. Corneal tissue levels of topically applied ofloxacin. J. Cataract Refract. Surg. 23:898-902, 1997.
18. Prosser, B.L.T., and Beskid, G. Multicenter in vitro comparative study of fluoroquinolones against 25, 129 Gram-positive and Gram-negative clinical isolates. Diagn. Microbiol. Infect. Dis. 21:33-45, 1995.
19. Hirose, T., Okezaki, E., Kato, H., Ito, Y., Inoue, M., and Mitsuhashi, S. In vitro and in vivo activity of NY-198, a new difluorinated quinolone. Antimicrobiol. Agents Chemother. 31:854-859, 1987.
20. Rittenhouse, S., McCloskey, L., Broskey, J., Niconovich, N., Jakielaszek, C., Poupard, J., and Coleman, K. In vitro antibacterial activity of gemifloxacin and comparator compounds against common respiratory pathogens. J. Antimicrobial Chemother. 45:S23-S27, 2000.
21. Biedenbach, D.J., and Jones, R.N. The comparative activity of levofloxacin tested against 350 clinical isolates of Streptococci. Diagn. Microbiol. Infect. Dis. 25:47-51, 1996.
22. Hoban, D.J., Bouchillon, S.K., Karlowsky, J.A., Johnson, J.L., Butler, D.L., Miller, L.A. Poupard, J.A., and The Gemifloxacin Surveillance Study Research Group. A comparative in vitro surveillance study of gemifloxacin activities against 2, 632 recent Streptococcus pneumoniae isolates from across Europe, North America, and South America. Antimicrobiol. Agents Chemother. 44:3008-3011, 2000.
23. Schaad, U.B. Use of the quinolones in paediatrics. Drugs 45:37-41, 1993.
24. Alghasham, A.A., and Nahata, M.C. Clinical use of fluoroquinolones in children. Ann. Pharmacother. 34:347-359, 2000.
25. Matsumura, K., Inoue, S., Ibuki, H., and Takashina, H. Plasma levels of ofloxacin after topical instillation in various age groups. Jpn. J. Clin. Ophthalmol. 45:1265-1268, 1991.