Phytol, SSADH inhibitory diterpenoid of Lactuca sativa

Archives of Pharmacal Research

Volumn 25, Issue 5, 2002, Pages 643-646

  Bang, Myun Ho ^a   Soo, Young Choi ^b   Jang, Tae O ^a   Sang, Kook Kim ^c   Kwon, Oh Shin ^c   Kang, Tae Cheon ^b   Moo, Ho Won ^b   Park, Jinseu ^b   Baek, Nam In ^a  

^a Kyung Hee University   (South Korea)

^b Hallym University   (South Korea)

^c Kyungpook National University   (South Korea)

Author keywords

Anticonvulsant; Lactuca sativa; Phytol; SSADH inhibition

Indexed keywords

ALDEHYDE DEHYDROGENASE; DITERPENE; ENZYME INHIBITOR; PHYTOL; PLANT EXTRACT; SUCCINATE SEMIALDEHYDE DEHYDROGENASE;

ANIMAL; ARTICLE; CATTLE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; ISOLATION AND PURIFICATION; LETTUCE; METABOLISM; PLANT;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; CATTLE; DITERPENES; ENZYME INHIBITORS; LETTUCE; PHYTOL; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE;

EID: 0036779582     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02976937     Document Type: Article

References (10)

1. Baek, N.-I., Choi, S. Y., Park, J. K., Cho, S.-W., Ahn, E.-M., Jeon, S. G., Lee, B. R., Bahn, J. H., Kim, Y. K., Shon, I. H., Isolation and identification of succinic semialdehyde dehydrogenase inhibitory compound from the rhizome of Gastrodia elata Blume. Arch. Pharm. Res., 22, 219-224 (1999).
2. Bradford, M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
3. Jung, M. J., Lippert, B., Metcalf, B., B hlen, P. and Schechter, P.J., Vinyl GABA (4-amino-hex-5-enoic acid), a new irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice. J. Neurochem, 29, 797-802 (1977).
4. Khalil, A.T., Abd El-fattah, H. and Mansour, E. S., Guaianolides from Lactuca saligna. Planta Medica, 57, 190-191 (1991).
5. Kitz, R. and Wilson, I.B., Esters of methanesulfonic acid as irreversible inhibitors of Acetylcholinesterase. J. Biol. Chem., 237, 3245-3249 (1962).
6. Lee, B.R., Hong, J.W., Yoo, B.K., Lee, S.J., Cho, S.W. and Choi, S.Y., Bovine brain succinic semialdehyde dehydrogenase; Purification, kinetics and reactivity of lysyl residues connected with catalytic activity, Mol. Cells, 5, 611-617 (1995).
7. Löscher, W., Valproate: a reappraisal of its phamacodynamic properties and mechanisms of action. Prog Neurobiol, 58, 31-59 (1999).
8. Olsen, R. W. and Avoli, M., GABA and epileptogenesis. Epilepsia, 38, 399-407 (1997).
9. Singh, B., Agrawal, P. K. and Thakur, R. S., Isolation of transphytol from Phyllanthus niruri. Planta Medica, 57, 98 (1991).
10. Soka, T., Dictionary of Chinese Drugs, Shanghai Science Technology Shogaukan (Eds.), Shogakukan Press, Tokyo, pp. 2816, 1985.