Overexpression of the 18 kDa and 22/24 kDa FGF-2 isoforms results in differential drug resistance and amplification potential

Journal of Cellular Physiology

Volumn 193, Issue 1, 2002, Pages 64-72

  Dini, Germana ^a,c   Funghini, Silvia ^a   Witort, Ewa ^b   Magnelli, Lucia ^a   Fanti, Elena ^b   Rifkin, Daniel B ^a   Rosso, Mario Del ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL SPREADING; DRUG EFFECT; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC SELECTION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

3T3 CELLS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ASPARTATE CARBAMOYLTRANSFERASE; ASPARTIC ACID; CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CLONE CELLS; DIFFUSION CHAMBERS, CULTURE; DIHYDROOROTASE; DRUG RESISTANCE; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTOR 2; FIBROBLASTS; GENE AMPLIFICATION; GENE EXPRESSION; IMMUNOBLOTTING; MICE; MOLECULAR WEIGHT; PHOSPHONOACETIC ACID; PROTEIN ISOFORMS; TRANSFECTION;

EID: 0036779372     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10152     Document Type: Article

References (26)

1. Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor
2. A rapid in vitro assay for quantitating the invasive potential of tumor cells
3. A new 34-Kilodalton isoform of human fibroblast growth factor 2 is cap dependently synthesized by using a non-AUG start codon and behaves as a survival factor
4. Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: Possible intracellular signaling by their high molecular weight forms
5. Subcellular distribution of multiple molecular weight forms of bFGF in hepatocyte cells
6. Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor
7. Potential oncogenic effects of basic fibroblast growth factor requires cooperation between CUG and AUG-initiated forms
8. The implication of angiogenesis for the biology and therapy of cancer metastasis
9. Human basic fibroblast growth factor gene encodes four polypeptides: Three initiate translation from non-AUG codons
10. Growth factor-regulated expression of enzymes involved in nucleotide biosynthesis: A novel mechanism of growth factor action
11. Fibroblast growth factor mediated alterations in drug resistance, and evidence of gene amplification
12. Drug resistance and gene amplification potential regulated by transforming growth factor beta gene expression
13. Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells
14. Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrmidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells
15. Direct effect of basic fibroblast growth factor on gene transcription in a cell system
16. Genetic instability in cancer cells: Relationship to tumor cell heterogeneity
17. Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells
18. Fibroblast growth factor-2
19. Transformation by basic fibroblast growth factor requires high levels of expression: Comparison with transformation by hst/K-FGF
20. Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells
21. Nuclear and cytoplasmic localization of different basic fibroblast growth factor species
22. Recent developments in the cell biology of basic fibroblast growth factor
23. Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA
24. Construction of a cDNA to the hamster CAD gene and its application toward defining the domain for aspartate transcarbamylase
25. Basic fibroblast growth factor accumulates in the nuclei of various bFGF-producing cell types
26. Growth factors in mechanisms of malignancy: Roles for TFG-beta and FGF