Phenothiazines and prion diseases: A potential mechanism of action towards oxidative stress [1]

International Journal of Antimicrobial Agents

Volumn 20, Issue 4, 2002, Pages 305-306

  Achour, Ammar ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIINFECTIVE AGENT; ANTIOXIDANT; CALCIUM ION; CALMODULIN; COPPER; HYDROXYL RADICAL; NEUROLEPTIC AGENT; PHENOTHIAZINE DERIVATIVE; VIRUS RECEPTOR;

AGRANULOCYTOSIS; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; BRAIN; CELL ACTIVATION; CELL CULTURE; CELL DEATH; CELL MEMBRANE; CELL METABOLISM; CELL STRUCTURE; CLINICAL PRACTICE; CREUTZFELDT JAKOB DISEASE; CYTOKINE RELEASE; DEGENERATIVE DISEASE; DRUG BINDING; DYSKINESIA; GRAY MATTER; HUMAN; INFLAMMATION; LETTER; LIPID PEROXIDATION; MICROGLIA; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; PLASMA; PRION; PRION DISEASE; PRIORITY JOURNAL; SCRAPIE AGENT; SPINAL CORD; VIRUS INHIBITION;

ANIMALS; HUMANS; OXIDATIVE STRESS; PHENOTHIAZINES; PRION DISEASES;

EID: 0036776079     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(02)00185-1     Document Type: Letter

References (7)

1. Korth C., May B.C.H., Cohen F.E., Prusiner S.B. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc. Natl. Acad. Sci. USA. 98:2001;9836-9841.
2. Amaral L., Kristiansen J.E. Phenothiazines: potential management of Creutzfeldt-Jacob disease and its variants. Int. J. Antimicrob. Agents. 18:2001;411-417.
3. Amaral L., Kristiansen J.E., Thomsen V.F., Markovich B. The effect of chlorprazine on the outer cell wall constituents of Salmonella typhimurium ensuring resistance to the drug. Int. J. Antimicrob. Agents. 14:2000;225-229.
4. Breugnot C., Mazière C., Salmon S., et al. Phenothiazines inhibit copper and endothelial cell-induced peroxidation of low-density lipoprotein. Biochem. Pharmacol. 9:1990;419-423.
5. Chandra D., Kale R.K. Influence of γ-rays on the mouse liver cytochrome system and its modulation by phenothiazine drugs. Int. J. Radiat. 75:1999;335-349.
6. Giese A., Kretzschmar H.A. Prion-induced neuronal damage-the mechanisms of neuronal destruction in subacut spongiform encephalopathies. Curr. Top. Microbiol. Immunol. 253:2001;203-217.
7. Milhavet O., McMahon H.E., Rachidi W., et al. Prion infection impairs the cellular response to oxidative stress. Proc. Natl. Acad. Sci. USA. 25:2000;13937-13942.