Characterization of the epitope of anti-lipoarabinomannan antibodies as the terminal hexaarabinofuranosyl motif of mycobacterial arabinans

Microbiology

Volumn 148, Issue 10, 2002, Pages 3049-3057

  Kaur, Devinder ^a   Lowary, Todd L ^a   Vissa, Varalashmi D ^a   Crick, Dean C ^a   Brennan, Patrick J ^a  

^a Immunology and Pathology   (United States)

Author keywords

Epitope definition; Hexa Araf motif; LAM; M. tuberculosis; Monoclonal antibodies

Indexed keywords

ARABINOGALACTAN; ARABINOSE DERIVATIVE; CROSS REACTING ANTIBODY; EPITOPE; HEXAARABINOFURANOSYL; LIPOARABINOMANNAN; MANNOSE; METHYLGLYCOSIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CS-35; MYCOLIC ACID; MYCOLYLARABINOGALACTAN; OLIGOSACCHARIDE; PEPTIDOGLYCAN; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BACTERIAL CELL WALL; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; MOLECULAR RECOGNITION; MYCOBACTERIUM; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0036774705     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-148-10-3049     Document Type: Article

References (41)

1. Belanger, A. E., Besra, G. S., Ford, M. E., Mikusova, K., Belisle, J. T., Brennan, P. J. & Inamine, J. M. (1996). The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc Natl Acad Sci USA 93, 11919-11924.
2. Britton, W. J., Hellqvist, L., Basten, A. & Raison, R. L. (1985). Mycobacterium leprae antigens involved in human immune responses. J Immunol 135, 4171-4177.
3. Chatterjee, D., Bozic, C. M., McNeil, M. R. & Brennan, P. J. (1991). Structural features of the arabinan component of the lipoarabinomannan of Mycobacterium tuberculosis. J Biol Chem 266, 9652-9660.
4. Chatterjee, D., Lowell, K., Rivoire, B., McNeil, M. R. & Brennan, P. J. (1992a). Lipoarabinomannan of Mycobacterium tuberculosis. J Biol Chem 267, 6234-6239.
5. Chatterjee, D., Roberts, A. D., Lowell, K., Brennan, P. J. & Orme, I. (1992b). Structural basis of lipoarabinomannan to induce secretion of tumor necrosis factor. Infect Immun 60, 1249-1253.
6. Cisar, J., Kabat, E. A., Dorner, M. M. & Liao, J. (1975). Binding properties of immunoglobin combining sites specific for terminal or nonterminal antigenic determinants in dextran. J Exp Med 142, 435-459.
7. Cygler, M., Rose, D. R. & Bundle, D. R. (1991). Recognition of a cell surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment. Science 253, 442-445.
8. 13C NMR analyses. J Biol Chem 265, 6734-6743.
9. Deng, L., Mikusova, K., Robuck, K. G., Scherman, M., Brennan, P. J. & McNeil, M. R. (1995). Recognition of multiple effects of ethambutol on the metabolism of the mycobacterial cell envelope. Antimicrob Agents Chemother 39, 694-701.
10. D'Souza, F. W. & Lowary, T. L. (2000). The first total synthesis of a highly branched arabinofuranosyl hexasaccharide found at the nonreducing termini of mycobacterial arabinogalactan and lipoarabinomannan. Org Lett 2, 1493-1495.
11. Escuyer, V. E., Lety, M.-A., Torelles, J. B. & 7 other authors (2001). The role of embA and embB gene products in the biosynthesis of terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan. J Biol Chem 276, 48854-48862.
12. Frehel, C. & Leduc, M. (1987). Cytochemical localization of lipopolysaccharides during peptidoglycan degradation of Escherichia coli cells. J Bacteriol 69, 210-217.
13. Gaylord, H., Brennan, P. J., Young, D. B. & Buchanan, T. M. (1987). Most Mycobacterium leprae carbohydrate reactive monoclonal antibodies are directed to lipoarabinomannan. Infect Immun 55, 2860-2863.
14. Glaudemans, C. P. J. (1987). Seven structurally different murine monoclonal galactan-specific antibodies show identity in their galactosyl-binding subsite arrangements. Mol Immunol 24, 371-377.
15. Hamasur, B., Kallenius, G. & Svenson, S. B. (1999). Synthesis and immunologic characterization of Mycobacterium tuberculosis lipoarabinomannan specific oligosaccharide-protein conjugates. Vaccine 17, 2853-2861.
16. Hirschfield, G. R., McNeil, M. R. & Brennan, P. J. (1990). Peptidoglycan-associated polypeptides of Mycobacterium tuberculosis. J Bacteriol 172, 1005-1013.
17. Hunter, S. W., Gaylord, H. & Brennan, P. J. (1986). Structure and antigenicity of the phosphorylated lipopolysaccharide antigens from the leprosy and tubercle bacilli. J Biol Chem 261, 12345-12351.
18. Kaplan, G., Gandhi, R. R., Weinstein, D. E., Levis, W. R., Patarroyo, M. E., Brennan, P. J. & Cohn, Z. A. (1987). Mycobacterium leprae antigen-induced suppression of T-cell proliferation in vitro. J Immunol 138, 3028-3034.
19. Khoo, K.-H., Tang, J.-B. & Chatterjee, D. (2001). Variation in mannose-capped terminal arabinan motifs of lipoarabinomannan from clinical isolates of Mycobacterium tuberculosis and Mycobacterium avium complex. J Biol Chem 276, 3863-3871.
20. Kikuchi, S., Ohinata, A., Tsumuraya, Y., Hashimoto, Y., Kaneko, Y. & Matsushima, H. (1993). Production and characterization of antibodies to the beta-(1 → 6)-galactotetraosyl group and their interaction with arabinogalactan-proteins. Planta 190, 525-535.
21. Knox, J. P., Linstead, P. J., Peart, J., Cooper, C. & Roberts, K. (1991). Developmentally regulated epitopes of cell surface arabinogalactan proteins and their relation to root tissue pattern formation. Plant J 1, 317-326.
22. Kotani, S., Kato, T., Matsuda, T., Kato, K. & Misaki, A. (1971). Chemical structure of the antigenic determinants of cell wall polysaccharide of Mycobacterium tuberculosis strain H37Rv. Biken J 14, 379-387.
23. Levy, S., York, W. S., Stuike-Prill, R., Meyer, B. & Staehelin, L. A. (1991). Simulations of the static and dynamic molecular conformations of xyloglucan. The role of fucosylated side chain in surface specific side chain folding. Plant J 1, 195-215.
24. McNeil, M. R., Daffe, M. & Brennan, P. J. (1991). Location of the mycolyl ester substituents in the cell walls of mycobacteria. J Biol Chem 266, 13217-13223.
25. Means, T. K., Wang, S., Lien, E., Yoshimura, A., Golenbock, D. T. & Fenton, M. J. (1999). Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 163, 3920-3927.
26. Mikusova, K., Slayden, R. A., Besra, G. S. & Brennan, P. J. (1995). Biogenesis of the mycobacterial cell wall and the site of action of ethambutol. Antimicrob Agents Chemother 39, 2484-2489.
27. Misaki, A., Seto, N. & Azuma, I. (1974). Structure and immunological properties of D-arabino-D-galactans isolated from cell walls of Mycobacterium species. J Biochem 76, 15-27.
28. Misaki, A., Azuma, I. & Yamamura, Y. (1977). Structural and immunochemical studies on D-arabino and D-mannan of Mycobacterium tuberculosis and other Mycobacterium species. J Biochem 82, 1759-1770.
29. Molloy, A., Gaudernack, G., Lewis, W. R., Cohn, Z. A. & Kaplan, G. (1990). Suppression of T-cell proliferation by Mycobacterium and its products: the role of lipopolysaccharides. Proc Natl Acad Sci USA 87, 973-977.
30. Moreno, C., Mehlert, A. & Lamb, J. (1988). The inhibitory effects of mycobacterial lipoarabinomannan and polysaccharides upon polyclonal and monoclonal human T cell proliferation. Clin Exp Immunol 74, 206-210.
31. Oomen, R. P., Young, N. M. & Bundle, D. R. (1991). Molecular modeling of antibody-antigen complexes between the Brucella abortus O-chain polysaccharide and a specific monoclonal antibody. Protein Eng 4, 427-433.
32. Pennell, R. I., Janniche, L., Scofield, G. N., Booij, H., de Vries, S. C. & Roberts, K. (1992). Identification of a transitional cell state in the developmental pathway to carrot somatic embryogenesis. J Cell Biol 119, 1371-1380.
33. Prinzis, S., Chatterjee, D. & Brennan, P. J. (1993). Structure and antigenicity of the phosphorylated lipoarabinomannan from Mycobacterium bovis BCG. J Gen Microbiol 139, 2649-2658.
34. Schlesinger, L. S., Hull, S. R. & Kaufman, T. M. (1994). Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages. J Immunol 152, 4070-4079.
35. Schlesinger, L. S., Kaufman, T. M., Iyer, S., Hull, S. R. & Marchiando, L. K. (1996). Differences in mannose receptor-mediated uptake of lipoarabinomannan from virulent and attenuated strains of Mycobacterium tuberculosis by human macrophages. J Immunol 157, 4568-4575.
36. Sieling, P. A., Chatterjee, D., Porcelli, S. A. & 8 other authors (1995). CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269, 227-230.
37. Takayama, K. & Kilburn, J. O. (1989). Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis. Antimicrob Agents Chemother 33, 1493-1499.
38. Telenti, A., Philipp, W. J., Sreevatsan, S., Bernasconi, C., Stockbauer, K. E., Wieles, B., Musser, J. M. & Jacobs, W. R., Jr (1997). The emb operon, a unique gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol. Nat Med 3, 567-570.
39. Tsuji, S., Uehori, J., Matsumoto, M., Suzuki, S. Y., Matsuhisa, A., Toyoshima, K. & Seya, T. (2001). Human intelectin is a novel soluble intelectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. J Biol Chem 276, 23456-23463.
40. Yin, H., D'Souza, F. W. & Lowary, T. L. (2002). Arabinofuranosides from mycobacteria: synthesis of a highly branched hexasaccharide and related fragments containing β-arabinofuranosyl residues. J Org Chem 67, 892-903.
41. Yoshida, A. & Koide, Y. (1997). Arabinofuranosyl-terminated and mannosylated lipoarabinomannans from Mycobacterium tuberculosis induce different levels of interleukin-12 expression in murine macrophages. Infect Immun 65, 1953-1955.