Intratracheal delivery of a single major histocompatibility complex class I peptide induced prolonged survival of fully allogeneic cardiac grafts and generated regulatory cells

Human Immunology

Volumn 63, Issue 10, 2002, Pages 888-892

  Akiyama, Yoshinobu ^a   Shirasugi, Nozomu ^b   Aramaki, Osamu ^b   Matsumoto, Kenji ^a   Shimazu, Motohide ^a   Kitajima, Masaki ^a   Ikeda, Yoshifumi ^b   Niimi, Masanori ^b  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

Cardiac transplantation; Major histocompatibility complex class I peptide; Mucosal tolerance; Regulatory cells; Trachea

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADOPTIVE TRANSFER; ANIMALS; GRAFT SURVIVAL; H-2 ANTIGENS; HEART TRANSPLANTATION; IMMUNE TOLERANCE; INTERFERON TYPE II; MICE; MICE, INBRED STRAINS; TRACHEA; TRANSPLANTATION, HOMOLOGOUS;

EID: 0036774515     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(02)00456-1     Document Type: Article

References (10)

1. Shirasugi N, Akiyama Y, Ikeda Y, et al: Intratracheal delivery of allo-antigen induces donor-specific hyporesponsiveness: Dendritic cells play a pivotal role as regulatory cells. Transplant Proc 33:86, 2001.
2. Shirasugi N, Ikeda Y, Akiyama Y, et al: Induction of hyporesponsiveness to fully allogeneic cardiac grafts by intratracheal delivery of allo-antigen. Transplantation 71:561, 2001.
3. Niimi M: The technique for heterotopic cardiac transplantation in mice: Experience of 3000 operations by one surgeon. J Heart Lung Transplant 20:1123, 2001.
4. Perros P, Weightman DR: Measurement of cell proliferation by enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody to bromodeoxyuridine. Cell Prolif 24:517, 1991.
5. Madsen JC, Superina RA, Wood KJ, Morris PJ: Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature 332:161, 1988.
6. Pullen JL, Horton RM, Cai ZL, Pease LR: Structural diversity of the classical H-2 genes: K, D, and L. J Immunol 148:953, 1992.
7. Honjo K, Xu XY, Bucy RP: Heterogeneity of T cell clones specific for a single indirect allo-antigenic epitope (I-Ab/H-2Kd54-68) that mediate transplant rejection. Transplantation 70:1516, 2000.
8. Akbari O, DeKruyff RH, Umetsu D: Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2:725, 2001.
9. Wise MP, Bemelman F, Cobbold SP, Waldmann H: Linked suppression of skin graft rejection can operate through indirect recognition. J Immunol 161:5813, 1998.
10. Niimi M, Shirasugi N, Ikeda Y, Wood KJ: Oral antigen induces allograft survival by linked suppression via the indirect pathway. Transplant Proc 33:81, 2001.