Dealing with intractable protein cores: Protein sequencing of the Mcg IgG and the Yvo IgM heavy chain variable domains

Journal of Molecular Recognition

Volumn 15, Issue 5, 2002, Pages 341-348

  Shaw, Denis C ^a   Shultz, Brandon B ^b   Ramsland, Paul A ^c   Edmundson, Allen B ^b  

^a Biology and Environment   (Australia)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c AUSTIN RESEARCH INSTITUTE   (Australia)

Author keywords

Antibody crystallography; Human monoclonal antibodies; Insoluble peptides; Protein sequencing

Indexed keywords

DODECYL SULFATE SODIUM; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; BENCE JONES PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; MYELOMA IMMUNOGLOBULINS; PARAPROTEIN;

AMINO ACID SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; SEQUENCE ANALYSIS; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTRICITY; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; WALDENSTROEM MACROGLOBULINEMIA; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BENCE JONES PROTEIN; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYELOMA PROTEINS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, PROTEIN; WALDENSTROM MACROGLOBULINEMIA;

EID: 0036761294     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmr.596     Document Type: Article

References (22)

1. Bhat TN, Cohen GH. 1984. OMITMAP: An electron density map suitable for examination of errors in a macromolecular model. J. Appl. Crystallogr. 17: 244-248.
2. Edmundson AB. 1963. Cleavage of sperm whale myoglobin with cyanogen bromide. Nature 198: 354-357.
3. Edmundson AB. 1965. Amino-acid sequence of sperm whale myoglobin. Nature 205: 883-887.
4. Edmundson AB, Hirs CHW. 1961. The amino-acid sequence of sperm whale myoglobin. Nature 190: 663-672.
5. Edmundson AB, Hirs CHW. 1962a. On the structure of sperm whale myoglobin. I. The amino acid composition and terminal groups of the chromatographically purified protein. J. Mol. Biol. 5: 663-682.
6. Edmundson AB, Hirs CHW. 1962b. On the structure of sperm whale myoglobin. II. The tryptic hydrolysis of the denatured protein. J. Mol. Biol. 5: 683-705.
7. Edmundson AB, Hirs CHW. 1962c. On the structure of sperm whale myoglobin. III. The amino acid sequences of the smaller tryptic peptides containing aromatic residues. J. Mol. Biol. 5: 706-708.
8. Edmundson AB, Ely KR, Abola EE, Schiller M, Panagiotopoulos N. 1975. Rotational allomerism and divergent evolution of domains in immunoglobulin light chains. Biochemistry 14: 3953-3961.
9. Ely KR, Herron JN, Edmundson AB. 1983. Three-dimensional structure of the orthorhombic form of the Mcg Bence-Jones dimer. In Progress in Immunology V, Yamamura Y, Tada T (eds)., Academic Press: Tokyo; 61-66.
10. Fett JW, Deutsch HF. 1974. Primary structure of the Mcg λ chain. Biochemistry 13: 4102-4114.
11. Fontana A, Vita C, Toniolo C. 1973. Chemical cleavage after tryptophan residues in proteins. FEBS Lett. 32: 139-142.
12. Gross E. 1967. The cyanogen bromide reaction. Meth. Enzymol. 11: 238-255.
13. Guddat LW, Herron JN, Edmundson AB. 1993. Three-dimensional structure of a human immunoglobulin with a hinge deletion. Proc. Natl Acad. Sci. USA 90: 4271-4275.
14. Gundlach HG, Stein WH, Moore S. 1959. The nature of the amino acid residues involved in the inactivation of ribonuclease by iodoacetate. J. Biol. Chem. 234: 1754-1760.
15. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. 1991. Sequences of Proteins of Immunological Interest, 5th Edn. Public Health Service, US. Department of Health and Human Services, National Institutes of Health: Bethesda, MD.
16. Kendrew JC, Watson HC, Strandberg BE, Dickerson RE, Phillips DC, Shore VC. 1961. A partial determination by X-ray methods and its correlation with chemical data. Nature 190: 666-670.
17. Messer M, Griffiths M, Rismiller PD, Shaw DC. 1997. Lactose synthesis in a Monotreme, the echidna (Tachyglossus aculeatus): Isolation and amino acid sequence of echidna alpha-lactalbumin. Comp. Biochem. Physiol. 118B: 403.
18. Plaut AG, Tomasi TB Jr. 1970. Immunoglobulin M: Pentameric Fcμ fragments released by trypsin at higher temperatures. Proc. Natl Acad. Sci. USA 65: 318-322.
19. Ramsland PA, Upshaw JL, Shultz BB, DeWitt CR, Chissoe III WF, Raison RL, Edmundson AB. 2001. Interconversion of different crystal forms of Fabs from human IgM cryoglobulins. J. Cryst. Growth 232: 204-214.
20. Rossmann MG. 1990. The molecular replacement method. Acta Crystallogr. A46: 73-82.
21. Schiffer M, Girling RL, Ely KR, Edmundson AB. 1973. Structure of a λ-type Bence-Jones protein at 3.5 Å resolution. Biochemistry 12: 4620-4631.
22. Watson HC, Kendrew JC. 1961. Comparison between the amino-acid sequences of sperm whale myoglobin and of human myoglobin. Nature 190: 670-672.