On the mechanism of interaction of organic solvents with the active site of α-chymotrypsin

Biochemistry (Moscow)

Volumn 67, Issue 9, 2002, Pages 1032-1036

  Belyaeva, E A ^a   Gra, D V ^a   Eremeev, N L ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Dimethylsulfoxide; Ethanol; Mechanism of action; chymotrypsin

Indexed keywords

ALCOHOL; CHYMOTRYPSIN; CHYMOTRYPSIN A; DIMETHYL SULFOXIDE; SOLVENT; TYROSINE; WATER;

ACYLATION; ARTICLE; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; CYCLIZATION; HYDROLYSIS; KINETICS;

ACYLATION; BINDING SITES; CHYMOTRYPSIN; CYCLIZATION; DIMETHYL SULFOXIDE; ETHANOL; HYDROLYSIS; KINETICS; SOLVENTS; TYROSINE; WATER;

EID: 0036756875     PISSN: 00062979     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020530220774     Document Type: Article

References (16)

1. Tomiuchi, Y., Kijima, T., and Rise, H. (1993) Bull. Chem. Soc. Jpn., 66, 1176-1181.
2. Kijima, T., Yamamoto, Sh., and Rise, H. (1996) Enzyme Microb. Technol., 18, 2-6.
3. Eremeev, N. L., Belyaeva, E. A., and Kazanskaya, N. F. (1999) Bioorg. Khim., 25, 444-449.
4. Mozhaev, V. V., Khmelnitsky, Yu. L., Sergeeva, M. V., Belova, A. B., Klyachko, N. L., Levashov, A. V., and Martinek, K. (1989) Ear. J. Biochem., 184, 597-602.
5. Belova, A. B., Mozhaev, V. V., Levashov, A. V., Sergeeva, M. V., Martinek, K., and Khmelnitsky, Yu. L. (1991) Biokhimiya, 56, 1923-1945.
6. Belyaeva, E. A., and Eremeev, N. L. (2000) Vestnik MGU. Ser. Khim., 41, 392-394.
7. Schechter, I., and Berger, A. (1967) Blochem. Biophys. Res. Commun., 27, 157-162.
8. Segal, D., Powers, J. C., and Cohen, G. H. (1971) Biochemistry, 10, 3728-3735.
9. Birktoft, J. J., and Blow, D. M. (1972) J. Mol. Biol., 68, 187-240.
10. Klyosov, A. A., and Tsetilin, V. I. (1977) Bioorg. Khim., 8, 1523-1530.
11. Aisina, R. B., Eremeev, N. L., Kazanskaya, N. F., and Lukasheva, E. V. (1981) Biokhimiya, 46, 979-985.
12. Berezin, I. V., Kazanskaya, N. F., and Klyosov, A. A. (1971) Biokhimiya, 36, 106-117.
13. Berezin, I.V., Kazanskaya, N. F., and Klyosov, A. A. (1971) FEBS Lett., 15, 121-124.
14. Frey, P. A., Whitt, S. A., and Tobin, J. B. (1994) Science, 264, 1927-1930.
15. Cassidy, C. S., Lin, J., and Frey, P. A. (1997) Biochemistry, 36. 4576-4584.
16. Lin, J., Cassidy, C. S., and Frey, P. A. (1998) Biochemistry, 37, 11940-11948.