Synthesis, β-adrenoceptor pharmacology and toxicology of S-(-)-1-(4-(2-ethoxyethoxy)phenoxy)-2-hydroxy-3-(2-(3,4-dimethoxyphenyl) ethylamino)propane hydrochloride, a short acting β1-specific antagonist

European Journal of Medicinal Chemistry

Volumn 37, Issue 9, 2002, Pages 731-741

  Jackman, Graham P ^a   Iakovidis, Dimitri ^a   Nero, Tracy L ^a   Anavekar, Nagesh S ^a   Rezmann Vitti, Linda A ^a   Louis, Simon N S ^a   Mori, Masanori ^a   Drummer, Olaf H ^a   Louis, William J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

D140S HCl; Pharmacology; Short acting antagonist; Synthesis; Toxicology; 1 Adrenoceptor antagonist

Indexed keywords

1 [4 (2 ETHOXYETHOXY)PHENOXY] 2 HYDROXY 3 [2 (3,4 DIMETHOXYPHENYL)ETHYLAMINO]PROPANE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; ESMOLOL; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG HALF LIFE; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; MALE; NONHUMAN; RAT; TACHYCARDIA;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ATENOLOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; HALF-LIFE; HEART ATRIA; INFUSIONS, INTRAVENOUS; MAGNETIC RESONANCE SPECTROSCOPY; MYOCARDIAL CONTRACTION; PROPANE; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-1; TRACHEA;

EID: 0036753655     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01399-5     Document Type: Article

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