Updated metaanalysis finds that interferon-α improves progression-free and overall survival in low-grade non-Hodgkin's lymphoma when administered with chemotherapy that contains anthracyclines or mitoxantrone

Clinical Lymphoma

Volumn 3, Issue 2, 2002, Pages 82-84

  Gibson, Angelia D ^a   Cheson, Bruce D ^a   Link, Brian ^a   Oken, Martin M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTHRACYCLINE DERIVATIVE; CHLORAMBUCIL; CHLORMETHINE; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; METHOTREXATE; MITOXANTRONE; PREDNIMUSTINE; PREDNISONE; PROCARBAZINE; TENIPOSIDE; VINCRISTINE; ANTINEOPLASTIC ANTIBIOTIC;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER REGRESSION; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; META ANALYSIS; NONHODGKIN LYMPHOMA; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; CLINICAL TRIAL; DISEASE FREE SURVIVAL; MIDDLE AGED; MORTALITY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBIOTICS, ANTINEOPLASTIC; CLINICAL TRIALS; DISEASE-FREE SURVIVAL; HUMANS; INTERFERON-ALPHA; LYMPHOMA, NON-HODGKIN; MIDDLE AGED; MITOXANTRONE;

EID: 0036753582     PISSN: 15269655     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1526-9655(11)70253-6     Document Type: Article

References (16)

1. Cheson BD. The curious case of the baffling biological. J Clin Oncol 2000; 18:2007-2009.
2. Chisesi T, Congiu M, Contu A, et al. Randomized study of chlorambucil (CB) compared to interferon (alfa-2b) combined with CB in low-grade non-Hodgkin's lymphoma: an interim report of a randomized study. Non-Hodgkin's Lymphoma Cooperative Study Group. Eur J Cancer 1991; 27(suppl 4):S31-S33.
3. Hagenbeek A, Carde P, Meerwaldt JH, et al. Maintenance of remission with human recombinant interferon alfa-2a in patients with stages III and IV low-grade malignant non-Hodgkin's lymphoma. European Organization for Research and Treatment of Cancer Lymphoma Cooperative Group. J Clin Oncol 1998; 16:41-47.
4. Arranz R, Garcia-Alfonso P, Sobrino P, et al. Role of interferon alfa-2b in the induction and maintenance treatment of low-grade non-Hodgkin's lymphoma: results from a prospective, multicenter trial with double randomization. J Clin Oncol 1998; 16:1538-1546.
5. Smalley RV, Andersen JW, Hawkins MJ, et al. Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma. N Engl J Med 1992; 327:1336-1341.
6. Smalley RV, Weller E, Hawkins MJ, et al. Final analysis of the ECOG I-COPA trial (E6484) in patients with non-Hodgkin's lymphoma treated with interferon alfa (IFN-alpha2a) plus an anthracycline-based induction regimen. Leukemia 2001; 15:1118-1122.
7. Solal-Celigny P, Lepage E, Brousse N, et al. Recombinant interferon alfa-2b combined with a regimen containing doxorubicin in patients with advanced follicular lymphoma. Groupe d'Etude des Lymphomes de l'Adulte. N Engl J Med 1993; 329:1608-1614.
8. Solal-Celigny P, Lepage E, Brousse N, et al. Doxorubicin-containing regimen with or without interferon alfa-2b for advanced follicular lymphomas: final analysis of survival and toxicity in the Groupe d'Etude des Lymphomes Folliculaires 86 Trial. J Clin Oncol 1998; 16:2332-2338.
9. Aviles A, Duque G, Talavera A, et al. Interferon alpha 2b as maintenance therapy in low grade malignant lymphoma improves duration of remission and survival. Leuk Lymphoma 1996; 20:495-499.
10. Peterson B, Petroni G, Oken M, et al. Cyclophosphamide verus cyclophosphamide plus interferon alpa2b in follicular low-grade lymphomas: an intergroup phase III trial (CALGB 8691 and EST 7486). Proc Am Soc Clin Oncol 1997; 16:14a (Abstract #48).
11. Rohatiner A, Radford J, Deakin D, et al. A randomized controlled trial to evaluate the role of interferon as initial and maintenance therapy in patients with follicular lymphoma. Br J Cancer 2001; 85:29-35.
12. Fisher RI, Dana BW, LeBlanc M, et al. Interferon alpha consolidation after intensive chemotherapy does not prolong the progression-free survival of patients with low-grade non-Hodgkin's lymphoma: results of the Southwest Oncology Group randomized phase III study 8809. J Clin Oncol 2000; 18:2010-2016.
13. Rohatiner A, Gregory W, Peterson B, et al. A metaanalysis (MA) of randomised trials evaluating the role of interferon (IFN) as treatment for follicular lymphoma. Proc Am Soc Clin Oncol 1998; 17:4a (Abstract #11).
14. Allen IE, Ross SD, Borden SP, et al. Metaanalysis to assess the efficacy of interferon-alpha in patients with follicular non-Hodgkin's lymphoma. J Immunother 2001; 24:58-65.
15. Rohatiner A, Gregory W, Peterson B, et al. A metaanalysis of randomised studies evaluation the role of interferon alpha as treatment for follicular lymphoma. Proc Am Soc Clin Oncol 2002; 18:264a (Abstract #1053).
16. Unterhalt M, Herrmann R, Tiemann M, et al. Prednimustine, mitoxantrone (PmM) vs cyclophosphamide, vincristine, prednisone (COP) for the treatment of advanced low-grade non-Hodgkin's lymphoma. German Low-Grade Lymphoma Study Group. Leukemia 1996; 10:836-843.