Efficacy of alcohol-based and alcohol-free melaleuca oral solution for the treatment of fluconazole-refractory oropharyngeal candidiasis in patients with AIDS

HIV Clinical Trials

Volumn 3, Issue 5, 2002, Pages 379-385

  Vasquez, Jose A ^a   Zawawi, Ahmed A ^a  

^a HARPER UNIVERSITY HOSPITAL   (United States)

Author keywords

Fluconazole refractory; Melaleuca; Oral candidiasis

Indexed keywords

ALCOHOL; AMPHOTERICIN B; ANTIRETROVIRUS AGENT; BREATH AWAY; CLOTRIMAZOLE; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; NYSTATIN; TEA TREE OIL;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; BURN; CANDIDA ALBICANS; CANDIDIASIS; CITY; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DRUG EFFICACY; DRUG FORMULATION; DRUG RESPONSE; FEMALE; FUNGUS CULTURE; FUNGUS ISOLATION; HUMAN; IN VITRO STUDY; MALE; OUTCOMES RESEARCH; OUTPATIENT DEPARTMENT; PHARYNGITIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SKIN TINGLING; SYMPTOMATOLOGY; THRUSH; UNIVERSITY; YEAST;

EID: 0036750099     PISSN: 15284336     EISSN: None     Source Type: Journal    
DOI: 10.1310/99dy-8q52-306a-v0aj     Document Type: Article

References (19)

1. Van Meter F, Gallo JW, Garcia-Rojas G, Tan MM, Silverman S. A study of oral candidiasis in HIV-positive patients. J Dent Hyg. 1994;68:30-34.
2. Greenspan D. Treatment of oropharyngeal candidiasis in HIV-positive patients. J Am Acad Dermatol. 1994; 31 (suppl):S51-S55.
3. Coker RJ, Fisher M, Tomlinson DR. Management of mycoses associated with HIV disease. Int J STD AIDS. 1995;6:408-412.
4. Silverman S Jr, Gallo JW, McKnight ML, Mayer P, deSanz S, Tan MM. Clinical characteristics and management responses in 85 HIV-infected patients with oral candidiasis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82:402-407.
5. Humphrey EM. New Australian germicide. Med J Aust. 1995;30:85.
6. Feinblatt HM. Cajeput-type oil (tea tree oil) for the treatment of furunculosis. J Natl Med Assoc. 1960;52:32-34.
7. Vazquez JA, Arganoza MT, Boikov D, Vaishampayan JK, Akins RA. In vitro susceptibilities of Candida and Aspergillus species to Melaleuca alternifolia (tea tree) oil. Rev Iberoam Micol. 2000;17:60-63.
8. D'Auria FD, Laino L, Strippoli V, Tecca M, Salvatore G, Battinelli L, Mazzanti G. In vitro activity of tea tree oil against Candida albicans mycelial conversion and other pathogenic fungi. J Chemother. 2001;3(4):377-383.
9. Hammer KA, Carson CF, Riley TV. Melaleuca alternifolia (tea tree) oil inhibits germ tube formation by Candida albicans. Med Mycol. 2000;38(5):355-362.
10. Banes-Marshall L, Cawley P, Phillips CA. In vitro activity of Melaleuca alternifolia (tea tree) oil against bacterial and Candida spp. isolates from clinical specimens. Br J Biomed Sci. 2001;58(3):139-145.
11. Concha JM, Moore LS, Holloway WJ. Antifungal activity of Melaleuca alternifolia (tea tree) oil against various pathogenic organisms. J Am Podiatr Med Assoc. 1998; 88(10):489-492.
12. Jandourek A, Vaishampayan JK, Vazquez JA. Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS. 1998;12(9):1033-1037.
13. National Committee for Clinical Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of yeast. Approved standard M27-A. Wayne, PA: National Committee for Clinical Laboratory Standards; 1997.
14. Hammer KA, Carson CF, Riley TV. Susceptibility of transient and commensal skin flora to the essential oil of Melaleuca alternifolia (tea tree oil). Am J Infect Control. 1996;24:186-189.
15. Brophy JJ, Davies NW, Southwell IA, Stiff IA, Williams LR. Chromatographic quality control for oil of Melaleuca terpinen-4-ol type (Australian tea tree). J Agric Food Chem. 1989;7:1330-1335.
16. Ramanoelina AR, Terron GP, Bianchini JP, Coulanges P. Antibacterial action of essential oils extracted from Madagascar plants. Arch Inst Pasteur Madagascar. 1987;153:217-226.
17. Carson CF, Riley TV. Antimicrobial activity of the major components of the essential oil of Melaleuca alternifolia. J Appl Bacteriol. 1995;78:264-269.
18. Nenoff P, Haustein UF, Brandt W. Antifungal activity of the essential oil of Melaleuca alternifolia (tea tree oil) against pathogenic fungi in vitro. Skin Pharmacol. 1996;9:388-394.
19. Buck DS, Nidorf DM, Addino JG. Comparison of two topical preparations for the treatment of onychomycosis: Melaleuca alternifolia (tea tree) oil and clotrimazole. J Fam Pract. 1994;38:601-605.