Ritonavir protects hippocampal neurons against oxidative stress-induced apoptosis

NeuroToxicology

Volumn 23, Issue 3, 2002, Pages 301-306

  Wan, Wenshuai ^a   DePetrillo, Paolo B ^a  

^a Division of Intramural Research   (United States)

Author keywords

4 Hydroxynonenal; Hippocampal neuron; Inhibitor; Oxidative stress; Ritonavir

Indexed keywords

4 HYDROXYNONENAL; PROTEINASE INHIBITOR; RITONAVIR;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; HIPPOCAMPUS; HOMEOSTASIS; HYDROPHOBICITY; NERVE CELL; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ALDEHYDES; ANIMALS; ANTI-HIV AGENTS; APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; NEURONS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RITONAVIR;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0036746189     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(02)00057-8     Document Type: Article

References (6)

1. Ishihara I, Minami Y, Nishizaki T, Matsuoka T, Yamamura H. Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line, vol. 279. Amsterdam: Elsevier, 2000. p. 97-100.
2. Keller JN, Hanni KB, Markesbery WR. 4-Hydroxynonenal increases neuronal susceptibility to oxidative stress. J Neurosci 1999;58:823-30.
3. Mark RJ, Lovell MA, Markesbery WR, Uchida K, Mattson MP. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide. J Neurochem 1997;68:255-64.
4. Mattson MP, Barger SW, Begley JG, Mark RJ. Calcium, free radicals, and excitotoxic neuronal death in primary cell culture. Meth Cell Biol 1995;46:187-216.
5. Wan W, DePetrillo PB. Ritonavir inhibition of calcium-activated neutral proteases. Biochem Pharmacol 2002;63:1481-4.
6. Zhu DM, Uckun FM. Calpain inhibitor II induces caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells as well as some solid tumor cells. Clin Cancer Res 2000;6(6):2456-63.