Enaminones in heterocyclic synthesis: A new regioselective synthesis of 2,3,6-trisubstituted pyridines, 6-substituted-3-aroylpyridines and 1,3,5-triaroylbenzenes

Journal of Heterocyclic Chemistry

Volumn 39, Issue 5, 2002, Pages 1035-1038

  Al Saleh, Balkis ^a   Abdelkhalik, Mervat Mohammed ^b   Eltoukhy, Afaf Mohammed ^c   Elnagdi, Mohammed Hilmy ^c  

^a KUWAIT UNIVERSITY   (Kuwait)

^b Ain Shams University   (Egypt)

^c CAIRO UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

(4 CHLOROPHENYL) [6 (4 CHLOROPHENYL)PYRIDIN 3 YL]METHANONE; (4 METHOXYPHENYL) [6 (4 METHOXYPHENYL)PYRIDIN 3 YL]METHANONE; 1 (2 METHYL 6 NAPHTHALEN 2 YLPYRIDIN 3 YL)ETHANONE; 1 (4 CHLOROPHENYL) 3 DIMETHYLAMINOPROP 2 EN 1 ONE; 1 [6 (4 CHLOROPHENYL) 2 METHYLPYRIDIN 3 YL]ETHANONE; 1,3,5 TRI 2 NAPHTHOYLBENZENE; 1,3,5 TRI 4 METHOXYBENZOYLBENZENE; 1,3,5 TRI 4 TOLUOYLBENZENE; 3 DIMETHYLAMINO 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 DIMETHYLAMINO 1 4 TOLYLPROP 2 EN 1 ONE; 3 DIMETHYLAMINO 1 NAPHTHALEN 2 YLPROP 2 EN 1 ONE; 4 TOLYL [6 (4 TOLYLPYRIDIN 3 YL)]METHANONE; ACETIC ACID; ACETOACETIC ACID DERIVATIVE; AMMONIUM ACETATE; BENZENE DERIVATIVE; ETHYL 2 METHYL 6 NAPHTHALEN 2 YLNICOTINATE; ETHYL 6 (4 CHLOROPHENYL) 2 METHYLNICOTINATE; ETHYL 6 (4 METHOXYPHENYL) 2 METHYLNICOTINATE; KETONE DERIVATIVE; NAPHTHALEN 2 YL (6 NAPHTHALEN 2 YLPYRIDIN 3 YL)METHANONE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0036745974     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570390528     Document Type: Article

References (20)

1. B. Al-Saleh, M. M. Abdelkhalik, A. Al-Enzy and M. H. Elnagdi, J. Chem. Res. (S) 654 (1999).
2. C. Reidlinger, R. Dworczak and H. Junek, Monatsh. Chem., 129, 1207 (1998).
3. M. Buback, J. Abeln, T. Hubsch, C. Ott and L. F. Tietze, Liebigs Ann. Chem., 9 (1995).
4. J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon and A. G. Giman, The Pharmacological Basis of Therapeutic, Goodman and Gillman's, ninth ed, 1070 (1996).
5. J. A. Joule, K. Mills and G. F. Smith, Heterocyclic Chemistry, third ed., Chapman & Hall, London, UK, 56-118 (1995).
6. A. R. Katritzky, Handbook of Heterocyclic Chemistry, Pergamon Press, Oxford, UK, 381-411 (1985).
7. E. Gräf and R. Troschütz, Synthesis, 1216 (1999).
8. P. Ollinger, W. Remp, H. Junek, Monatsh. Chem., 105, 346 (1974).
9. P. Lue and J. V. Greenhill, Adv. Heterocycl. Chem., 67, 207 (1997); editor A. R. Katritzky, Academic Press, New York.
10. F. Al-Omran, N. Al-Awadi, A. A. El-Khair and M. H. Elnagdi, Org. Prep. Proced. Int., 29, 285 (1997);
11. S. M. Agamy, M. M. A. Abdebkhaler, M. H. Mohamed and M. H, Elnagdi, Z. Naturforsch, 56b, 1074 (2001).
12. S. M. Al-Mousawi, K. S. George and M. H. Elnagdi, Pharmazie, 8, 54 (1999).
13. E. Breitmaier, Structure Elucidation by NMR in Organic Chemistry, A Practical Guide, John Wiley & Sons Ltd, Chichester, UK, 27 (1993).
14. M. M. Abdelkhalik, M. H. Elnagdi and S. M. Agamy, Synthesis, 1166 (2000).
15. K. M. Al-Zaydi, E. A. Hafez and M. H. Elnagdi, J. Chem. Res. (S), 154 (2000).
16. M. M. Abdelkhalik, S. M. Agamy and M. H. Elnagdi, Z. Naturforsch, 55b, 1211 (2000).
17. B. Al-Saleh, N. Al-Awadi, H. Al-Kandari, M. M. Abdelkhalik and M. H. Elnagdi, J. Chem. Res. (S) 16 (2000).
18. U. P. Basu, J. Indian Chem. Soc., 12, 289 (1935).
19. M. M. Abdelkhalik and M. H. Elnagdi, Synthetic Communications, 32, 153 (2002).
20. F. Al-Omran, M. M. Abdelkhalik, A. Abou-Elkhair and M. H. Elnagdi, Synthesis, 91 (1997).