Effect of mifepristone on pregnancy, pregnancy-specific protein B (PSPB), progesterone, estradiol-17β, prostaglandin F2α (PGF2α) and prostaglandin E (PGE) in ovariectomized 90-day pregnant ewes

Prostaglandins and Other Lipid Mediators

Volumn 70, Issue 1-2, 2002, Pages 195-208

  Weems, Y S ^a   Bridges, P J ^a   Sasser, R G ^b   Ching, L ^a   LeaMaster, B R ^a   Vincent, D L ^a   Weems, C W ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF IDAHO   (United States)

Author keywords

Ewes; Mifepristone; Pregnancy; Prostaglandin PGF2

Indexed keywords

ANTIGESTAGEN; DRUG VEHICLE; ESTRADIOL; MIFEPRISTONE; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROGESTERONE; PROSTAGLANDIN E; PROSTAGLANDIN F2 ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FIRST TRIMESTER PREGNANCY; NONHUMAN; OVARIECTOMY; SHEEP; STEROID RELEASE;

ABORTION, INDUCED; ANIMALS; ASPARTIC ENDOPEPTIDASES; DINOPROST; ESTRADIOL; FEMALE; MIFEPRISTONE; OVARIECTOMY; OVARY; PREGNANCY; PREGNANCY MAINTENANCE; PREGNANCY PROTEINS; PREGNANCY, ANIMAL; PROSTAGLANDINS E; RECEPTORS, PROGESTERONE; SHEEP;

EID: 0036744106     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(02)00110-7     Document Type: Article

References (43)

1. 2α) on sources of progesterone and pregnancy in intact, ovariectomized and hysterectomized 90-100 day pregnant ewes. Prostaglandins. 43:1992;203-222.
2. 2α) on secretion of estradiol-17β and cortisol in 90-100 day hysterectomized, intact and ovariectomized pregnant ewes. Prostaglandins. 48:1994;139-156.
3. Weems CW, Weems YS, Vincent DL. Maternal recognition of pregnancy and maintenance of gestation in sheep. In: Enne G, Greppi G, and Lauria A, editors. Reproduction and animal breeding: advances and strategies. Proceedings of the 30th Spallanzani Internationale Simposia Societe Di Zootecnia, Milan, Italy. Amsterdam: Elsevier, 1995. p. 227-93.
4. 2α during mid-gestation and gonadotropin releasing hormone after parturition. Prostaglandins. 47:1994;333-343.
5. Alexander G., Williams D. Progesterone and placental development in sheep. J. Endocrinol. 32:1966;241-249.
6. 2α in vivo on 90-100 day hysterectomized intact, or ovariectomized pregnant ewes. Prostaglandins. 46:1993;277-296.
7. Cadepond F., Ulmann A., Baulieu E.E. RU 486 (mifepristone) mechanisms of action and clinical uses. Annu. Rev. Med. 48:1997;129-156.
8. Wang C.C., Wang W.C., Bardin C.W. Termination of early pregnancy in the rat, rabbit and hamster with RU 486 and anoridin. Contraception. 47:1993;597-608.
9. Hill N.C.W., Lopez Bernal A., Ferguson J., Mackenzie I.Z. The effect of the anti-progestin mifepristone (RU 486) on plasma prostaglandin metabolite levels in early pregnancy and its influence on pregnancy termination. Acta Obstet. Gynecol. Scand. 69:1990;321-328.
10. Swahn M.L., Bygedeman M., Chen J.K., Genzell-Danielsson K., Song S., Yang Q.Y.et al. Once-a-month treatment with a combination of mifepristone and the prostaglandin analogue misoprostol. Hum. Reprod. 14:1999;485-488.
11. Gazal O.S., Li Y., Schwabe C., Anderson L.L. Alteration of antepartum relaxin surge and induction of parturition by antiprogesterone RU 486 in sheep. J. Reprod. Fertil. 97:1993;233-240.
12. Olanini B.J., Li Y., Anderson L.L. Mifepristone (RU 486) induces parturition in primiparous beef heifers and reduces incidence of dystocia. J. Anim. Sci. 73:1995;3421-3426.
13. 2α) on secretion of pregnancy specific protein B (PSPB) and placentome weights in intact and ovariectomized 90-100 day pregnant ewes. Prostaglandins. 48:1994;377-387.
14. Steele RGD, Torrie JN. Principles and procedures of statistics. New York: McGraw-Hill, 1960.
15. Gill J.L., Hafs H.D. Analysis of repeated measurements of animals. J. Anim. Sci. 33:1971;331-336.
16. Nathanielsz, PW. The regulation of the switch from myometrial contractions in the late pregnancy: studies in the sheep and monkey. In: Gluckman PD, Johnson BM, and Nathanielsz PW, editors. Advances in fetal physiology. New York: Perinatology Press, 1998. p. 409-28.
17. Wray S. Uterine contraction and physiological mechanisms of modulation. Am. J. Physiol. 261:1993;C1-C18.
18. Garfield RE. Structural and functional studies of the control of myometrial contractility and labor. In: McNellis D, Challis J, Macdonald P, Nathanielsz P, Roberts J, editors. Onset of labor and integrative mechanisms. Itha, NY: Perinatology Press, 1988. p. 55-68.
19. Taylor M.J. Concentrations of progesterone and estradiol-17β after administration of a 3β-hydoxysteroid dehydrogenase inhibitor to sheep in late pregnancy. J. Endocrinol. 113:1987;97-108.
20. 2α) or cortisol aborts 90-day pregnant lutectomized sheep. Prostaglandins Other Lipid Mediat. 58:1999;77-86.
21. 2α, estradiol-17β, and progesterone secretion and pregnancy of 90-day ovariectomized pregnant ewes. Prostaglandins Other Lipid Mediat. 58:1999;149-158.
22. 2α, and estradiol-17β secretion in 80 to 90-day pregnant sheep. Prostaglandins Other Lipid Mediat. 58:1999;167-178.
23. 2α, indomethacin, tamoxifen, or estradiol-17β on incidence of abortion, progesterone and pregnancy specific protein B (PSPB) secretion in 88- to 90-day pregnant sheep. Prostaglandins Other Lipid Mediat. 58:1999;113-124.
24. Challis J.R.G., Harrison F.A., Heap B.A. The metabolic clearance rate, production rate, and conversion ratios of estrone in sheep. J. Endocrinol. 58:1973;435-446.
25. Findlay J.K., Seamark The biosynthesis of oestrogens in the ovine placental unit. J. Reprod. Fertil. 24:1971;141-142.
26. Carnegie J.A., Robertson H.A. Conjugated and unconjugated estrogens in fetal and maternal fluids of the pregnant ewe: a possible role for estrone sulfate during early pregnancy. Biol. Reprod. 19:1978;202-213.
27. Hamon M.H., Heap R.B. Progesterone and oestrogen concentrations in plasma of Barbary sheep (Ammotragus leovia, aoudad) compared with those of domestic pregnancy. J. Reprod. Fertil. 90:1990;207-214.
28. Ford S.P., Weems C.W., Pitts R., Pexton J.E., Inskeep E.K. Effects of estradiol-17α and progesterone on prostaglandin F in sheep uteri and uterine venous plasma. J. Anim. Sci. 41:1975;407-413.
29. Bolt D.J., Hawk H.W. Prevention of estrogen-induced regression of corpora lutea in ewes by hysterectomy. J. Anim. Sci. 40:1975;687-696.
30. Rice G.E., Wong M.H., Ralph M.M., Thorburn G.D. Ovine allantois fluid inhibition of prostaglandin synthesis in cotyledon microsomes. J. Endocrinol. 89(Suppl):1981;67-75.
31. Thorburn GD. The placenta, prostaglandins and parturition. Reprod Fertil Dev 1991;227-99.
32. Morgan G.L., Geisert R.D., McCann J.P., Bazer F.W., Ott T.L., Mirando M.A.et al. Failure of luteolysis and extension of the interestrous interval in sheep treated with the progesterone antagonist mifepristone (RU 486). J. Reprod. Fertil. 98:1993;451-457.
33. 2α by an enzyme in sheep blood. Biochem. Biophys. Acta. 348:1974;145-149.
34. 2 ketoreductase activity in cyclic and pregnant ewes. Prostaglandins. 44:1992;37-43.
35. 2 concentrations in ovariectomized and pregnant rats. Prostaglandins. 53:1997;187-197.
36. Miller J.M., Garfield R.E., Daniel E.E. Improved propagation in myometrium associated with gap junctions during parturition. Am. J. Physiol. 256:1989;C130-C143.
37. Leray O.S. Uterine contraction and physiological mechanisms of modulation. Am. J. Physiol. 268:1993;C1-C28.
38. Tabbit T., Thilander G., Grover A., Hertzberg E., Garfield R.E. An immunochemical and immunocytologic study of the increases in myometrial gap junctions (and connexin 43) in rats and humans during pregnancy. Am. J. Obstet. Gynecol. 167:1992;559-569.
39. Radestad A., Christensen N.J., Stromberg L. Induced cervical ripening with mifepristone in first trimester abortion. A double blind randomized biomechanical study. Contraception. 38:1988;301-308.
40. 2α after treatment with mifepristone in the first trimester of pregnancy. Prostaglandins. 49:1955;41-48.
41. Thorburn G.D., Challis J.R.G. Control of parturition. Physiol. Rev. 59:1979;863-889.
42. Thorburn G.D., Nicol D.H., Bassett J.M., Shutt D.A., Cox R.I. Parturition in the goat and sheep. Changes in corticosteroids, progesterone, oestrogens and prostaglandins. J. Reprod. Fertil. 16(Suppl):1972;61-79.
43. 2α and pregnancy specific protein B by 90 day intact and ovariectomized pregnant ewes. Prostaglandins Other Lipid Mediat. 58:1999;139-149.