The bystander effect in experimental systems and compatibility with radon-induced lung cancer in humans

Journal of Radiological Protection

Volumn 22, Issue 3 A, 2002, Pages

  Little, M P ^a   Wakeford, R ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b SELLAFIELD LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENS; TUMORS;

PARTICLE EXPOSURE;

RADIOLOGY;

RADON;

ANIMAL CELL; BYSTANDER EFFECT; CANCER RISK; CONFERENCE PAPER; EPIDEMIOLOGICAL DATA; HEALTH SURVEY; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG CANCER; LUNG CARCINOGENESIS; MALIGNANT TRANSFORMATION; NONHUMAN; PARTICLE RADIATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION HAZARD; STATISTICAL ANALYSIS;

EID: 0036742920     PISSN: 09524746     EISSN: None     Source Type: Journal    
DOI: 10.1088/0952-4746/22/3A/324     Document Type: Conference Paper

References (12)

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3. Huo L, Nagasawa H and Little J B 2001 HPRT mutants induced in bystander cell by very low fluences of alpha particles result primarily from point mutations Radiat. Res. 156 521-5
4. Little M P 2002 Comparisons of lung tumour mortality risk in the Japanese A-bomb survivors and in the Colorado Plateau uranium miners: support for the ICRP lung model Int. J. Radiat. Biol. 78 145-63
5. Little M P and Wakeford R 2001 The bystander effect in C3H 10T1/2 cells and radon-induced lung cancer Radiat. Res. 156 695-9
6. Lubin J H 2000 Radon in houses and risk of lung cancer: direct evidence of a significant association Radiation Research, vol 2, Proc. 11th Int. Congr. of Radiation Research (Dublin, Ireland, 18-23 July 1999) ed M Moriarty, C Mothersill, C Seymour, M Edington, J F Ward and R J M Fry (Lawrence, KS: Allen Press) pp 777-9
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8. Nagasawa H and Little J B 1999 Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect Radiat. Res. 152 552-7
9. National Research Council, Committee on Health Risks of Exposure to Radon 1999 Health Effects of Exposure to Radon (BEIR VI) (Washington, DC: National Academy Press)
10. Sawant S G, Randers-Pehrson G, Geard C R, Brenner D J and Hall E J 2001 The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells Radiat. Res. 155 397-401
11. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2000 Sources and Effects of Ionizing Radiation (New York: United Nations)
12. Zhou H, Suzuki M, Randers-Pehrson G, Vannais D, Chen G, Trosko J E, Waldren C A and Hei T K 2001 Radiation risk to low fluences of α particles may be greater than we thought Proc. Natl Acad. Sci. USA 98 14 410-15