CD40-mediated p38 mitogen-activated protein kinase activation is required for immunoglobulin class switch recombination to IgE

Journal of Allergy and Clinical Immunology

Volumn 110, Issue 3, 2002, Pages 421-428

  Zhang, Ke ^a   Zhang, Ling ^a   Zhu, Daocheng ^a   Bae, David ^a   Nel, Andre ^a   Saxon, Andrew ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibody; B lymphocyte; Gene rearrangement; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD40 ANTIGEN; DNA; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RNA; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0036739925     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.126382     Document Type: Article

References (37)

1. Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998;16:111-35.
2. Van Kooten C, Banchereau J. CD40-CD40 ligand: a multifunctional receptor-ligand pair. Adv Immunol 1996;61:1-77.
3. Clark EA, Ledbetter JA. How B and T cells talk to each other. Nature 1994;367:425-7.
4. Rothe M, Sarma V, Dixit VM, Goeddel DV. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 1995;269:1424-7.
5. Lee HH, Dempsey PW, Parks TP, Zhu X, Baltimore D, Cheng G. Specificity of CD40 signaling: involvement of TRAF2 in CD40-induced NF-κB activation and intercellular adhesion molecule-1 up-regulation. Proc Natl Acad Sci U S A 1999;96:1421-5.
6. Ishida T, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, et al. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc Natl Acad Sci U S A 1996;93:9437-42.
7. Hu HM, O'Rourke K, Boguski MS, Dixit VM. A novel RING finger protein interacts with the cytoplasmic tail of CD40. J Biol Chem 1994;269:30069-72.
8. Sakata N, Patel HR, Terada N, Aruffo A, Johnson GL, Gelfand EW. Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells. J Biol Chem 1995;270:30823-8.
9. Berberich I, Shu G, Siebelt F, Woodgett JR, Kyriakis JM, Clark EA. Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases. EMBO J 1996:15:92-101.
10. Karras JG, Wang Z, Huo L, Frank DA, Rothstein TL. Induction of STAT protein signaling through the CD40 receptor in B lymphocytes. J Immunol 1997;159:4350-5.
11. Ren CL, Morio T, Fu SM, Geha RS. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C2. J Exp Med 1994;179:673-80.
12. Gulbins E, Brenner B, Schlottmann K, Koppenhoefer U, Linderkamp O, Coggeshall KM, et al. Activation of the Ras signaling pathway by the CD40 receptor. J Immunol 1996;157:2844-50.
13. Berberich I, Shu GL, Clark EA. Cross-linking CD40 on B cells rapidly activates nuclear factor-B. J Immunol 1994;153:4357-66.
14. Suttles J, Milhom DM, Miller RW, Poe JC, Wahl LM, Wahl LM. CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. J Biol Chem 1999;274:5835-42.
15. Aruffo A, Farrington M, Hollenbaugh D, Li X, Milatovich A, Nonoyama S, et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper IgM syndrome. Cell 1993;72:291-301.
16. Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1994;1:167-77.
17. Xu J, Foy TM, Laman JD, Elliott EA, Dunn JJ, Waldschmidt TJ, et al. Mice deficient for the CD40 ligand. Immunity 1994;1:423-30.
18. Iciek LA, Delphin SA, Stavnezer J. CD40 cross-linking induces IgE germline transcripts in B cells via activation of NF-B: synergy with IL-4 induction. J Immunol 1997;158:4769-79.
19. Gauchat JF, Lebman DA, Coffman RL, Gascan H, de Vries JE. Structure and expression of germline e transcripts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 1990;172:463-73.
20. Kinoshita K, Tashiro J, Tomita S, Lee CG, Honjo T. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. Immunity 1998;9:849-58.
21. Grant PA, Andersson T, Neumth MF, Amlampalam V, Bauch A, Muller R, et al. A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3′ enhancen EMBO J 1996;15:6691-700.
22. Snapper CF, Marcu KB, Zelazowski P. The immunoglobulin class switch: beyond "accessibility". Immunity 1997;6:217-23.
23. Craxton A, Shu G, Graves JD, Saklatvala, Krebs JE, Clark EA. p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol 1998;161:3225-36.
24. Arimura Y, Ogimoto M, Mitomo K, Katagiri T, Yamamoto KI, Volarevic S, et al. CD45 is required for CD40-induced inhibition of DNA synthesis and regulation of c-Jun NH2-terminal kinase and p38 in BAL-17 B cells. J Biol Chem 2001;276:8550-6.
25. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995;364:229-35.
26. Zhang K, Clark EA, Saxon A. CD40 stimulation provides an IFN-γ-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production. J Immunol 1991;146:1836-42.
27. Tary-Lehmann M, Saxon A. Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J Exp Med 1992;175:503-16.
28. Faris M, Kokot N, Lee L, Nel AE. Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in Jurkat T cells: evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation. J Biol Chem 1996;271:27366-73.
29. Chu CC, Paul WE, Max EE. Quantitation of immunoglobulin m-gl heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method. Proc Natl Acad Sci U S A 1992;89:6978-82.
30. Muto T, Muramatsu M, Taniwaki M, Kinoshita K, Honjo T. Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene. Genomics 2000;68:85-8.
31. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995;270:27489-94.
32. Vlahoe CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinosital 3-kinase, 2-(4-morphelinyl)-8-phenyl-4H-1-benzopyran4-one (LY294002). J Biol Chem 1994;269:5241-8.
33. Worm M, Geha RS. CD40-mediated lymphotoxin expression in human B cells is tyrosine kinase dependent. Eur J Immunol 1995;25:2438-46.
34. Chin AD, Shu J, Shi CS, Yao Z, Kehrl JH, Cheng G. TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. Mol Cell Biol 1999;19:6665-72.
35. Lorenz M, Jung S, Radbruch A. Switch transcripts in immunoglobulin class switching. Science 1995;267:1825-8.
36. Brady K, Fitzgerald S, Ingvarsson S, Borrebaeck CAR, Moynagh PN. CD40 employs p38 MAP kinase in IgE isotype switching. Biochem Biophys Res Commun 2001;289:276-81.
37. Kanda K, Hu H-M, Zhang L, Grandchamps J, Boxer L. NF-κB activity is required for the deregulation of c-myc expression by the immunoglobulin heavy chain enhancer. J Biol Chem 2000;275:32338-46.