High leg motor activity in sleep apnea hypopnea patients: Efficacy of clonazepam combined with nasal CPAP on polysomnographic variables

Respiratory Medicine

Volumn 96, Issue 9, 2002, Pages 693-699

  Noseda, A ^a   Nouvelle, M ^a   Lanquart, J P ^a   Kempenaers, Ch ^a   De Maertelaer, V ^b   Linkowski, P ^a   Kerkhofs, M ^a  

^a ERASME HOSPITAL   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Clonazepam; Nasal continuous positive airway pressure; Periodic leg movement syndrome; Sleep apnea hypopnea syndrome; Sleep fragmentation

Indexed keywords

CLONAZEPAM; PLACEBO;

ACTIMETRY; ADULT; ARTICLE; BREATHING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; HIGH LEG MOTOR ACTIVITY; HUMAN; LEG MOVEMENT; MALE; MOTOR DYSFUNCTION; POLYSOMNOGRAPHY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; SLEEP; SLEEP APNEA SYNDROME;

EID: 0036739226     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1053/rmed.2002.1333     Document Type: Article

References (22)

1. Guilleminault C, Philip P. Tiredness and somnolence despite initial treatment of obstructive sleep apnea syndrome (What to do when an OSAS patient stays hypersomnolent despite treatment). Sleep 1996; 19: S117-S122.
2. Krueger BR. Restless legs syndrome and periodic movements of sleep. Mayo Clin Proc 1990; 65: 999-1006.
3. Ancoli-Israel S, Kripke DF, Mason W, Messin S. Sleep apnea and nocturnal myoclonus in a senior population. Sleep 1981; 4: 349-358.
4. Culpepper WJ, Bedia P, Shaffer JI. Time-of-night patterns in PLMS activity. Sleep 1992; 15: 306-311.
5. Peled R, Lavie P. Double blind evaluation of clonazepam on periodic leg movements in sleep. J Neurol Neurosurg Psychiatry 1987; 50: 1679-1681.
6. Guilleminault C. Benzodiazepines, breathing and sleep. Am J Med 1990; 88: 25S-28S.
7. Fry JM, Di Phillipo MA, Pressman MR. Periodic leg movements in sleep following treatment of obstructive sleep apnea with nasal continuous positive airway pressure. Chest 1989; 96: 89-91.
8. Ancoli-Israel S, Kripke DF, Mason W, Kaplan OJ. Sleep apnea and periodic movements in an aging sample. J Gerontol 1985; 4: 419-425.
9. Hartman PG, Scrima L. Muscle activity in the legs associated with frequent arousals in narcoleptics, nocturnal myoclonus and obstructive sleep apnea patients. Clin Electroencephalogr 1986; 17: 181-186.
10. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages in human Subjects, NIH Publication 204. Bethesda, MD: US Government Printing Office, 1968.
11. Coleman RM. Periodic leg movements in sleep (nocturnal myoclonus) and restless leg syndrome. In: Guilleminault C. (ed). Sleep and Waking: Indications and Techniques. Boston: Butterworths, 1982; 265-296.
12. Kazenwadel J, Pollmächer Th, Trenkwalder C, et al. New actigraphic assessment method for periodic leg movements (PLM). Sleep 1995; 18: 689-697.
13. Bonora M, St John WM, Bledsoe TA. Differential elevation by protriptyline and depression by diazepam of upper airway respiratory motor activity. Am Rev Respir Dis 1985; 131: 41-45.
14. Berry RB, Kouchi K, Bower J, Prosise G, Light RW. Triazolam in patients with obstructive sleep apnea. Am J Respir Crit Care Med 1996; 151: 450-454.
15. Dolly FR, Block AJ. Effects of flurazepam on sleep-disordered breathing and nocturnal oxygen desaturation in asymptomatic subjects. Am J Med 1982; 73: 239-243.
16. Guilleminault C, Silvestri R, Mondini S, Coburn S. Ageing and sleep apnea: action of benzodiazepine, acetazolamide, alcohol and sleep deprivation in a healthy elderly group. J Gerontol 1984; 39: 655-661.
17. Mc Call WV, Haponik E. Relationship of nasal continuous positive airway pressure to periodic limb movement disorder in a patient without sleep apnea. Chest 1993; 103: 1612-1614.
18. He J, Kryger MH, Zorick FJ, Conway W, Roth T. Mortality and apnea index in obstructive sleep apnea. Experience in 385 male patients. Chest 1988; 94: 9-14.
19. Ryan CF, Lowe AA, Li D. Magnetic resonance imaging of the upper airway in obstructive sleep apnea before and after chronic nasal continuous positive airway pressure therapy. Am Rev Respir Dis 1991; 144: 939-944.
20. Guilleminault C, Crowe C, Quera-Salva MA, Miles L, Partinen M. Periodic leg movement, sleep fragmentation and central sleep apnoea in two cases: reduction with clonazepam. Eur Respir J 1988; 1: 762-765.
21. Montplaisir J, Godbout R. Restless leg syndrome and periodic movements during sleep. In: Kryger MH, Roth T, Dement WC, (eds). Principles and Practice of Sleep Medicine. Philadelphia: WB Saunders, 1989; 402-408.
22. Höijer U, Hedner J, Ejnall H, Grunstein R, Odelberg E, Elam M. Nitrazepam in patients with sleep apnoea: a double-blind placebo-controlled study. Eur Respir J 1994; 7: 2011-2015.