Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes

Journal of Lipid Research

Volumn 43, Issue 9, 2002, Pages 1555-1562

  Waterman, Ian J ^a   Price, Nigel T ^a   Zammit, Victor A ^a  

^a HANNAH RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Development; Diacylglycerol acyltransferase; Secretion; Triglyceride; Very low density lipoproteins

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE; ISOENZYME; MESSENGER RNA; TRIACYLGLYCEROL; ACYLTRANSFERASE; DGAT1 PROTEIN, RAT; FATTY ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; FATTY LIVER; LIPID DIET; LIVER DEVELOPMENT; LIVER MICROSOME; MICROSOME MEMBRANE; NONHUMAN; ONTOGENY; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; RAT; RNA ANALYSIS; SUCKLING; WEANING; ANIMAL; CYTOLOGY; ENZYMOLOGY; FAT INTAKE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LIVER; LIVER CELL; METABOLISM; NEWBORN; POLYMERASE CHAIN REACTION; SECRETION; TIME; WISTAR RAT;

ACYLTRANSFERASES; ANIMALS; ANIMALS, NEWBORN; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIETARY FATS; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; LIVER; MICROSOMES, LIVER; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RNA, MESSENGER; TIME FACTORS; TRIGLYCERIDES; WEANING;

EID: 0036737798     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M200051-JLR200     Document Type: Article

References (37)

1. Owen, M. R., C. C. Corstorphine, and V. A. Zammit. 1997. Overt and latent activities of diacylglycerol acytransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion. Biochem. J. 323: 17-21.
2. Owen, M., and V. A. Zammit. 1997. Evidence for overt and latent forms of DGAT in rat liver microsomes. Implications for the pathways of triacylglycerol incorporation into VLDL. Biochem. Soc. Trans. 25: 21S.
3. Zammit, V. A. 1999. The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function. Biochem. J. 343: 505-515.
4. Zammit, V. 1999. Carnitine acyltransferases: functional significance of subcellular distribution and membrane topology. Prog. Lipid Res. 38: 199-224.
5. Olofsson, S. O., L. Asp, and J. Boren. 1999. The assembly and secretion of apolipoprotein B-containing lipoproteins. Curr. Opin. Lipidol. 10: 341-346.
6. Wiggins, D., and G. F. Gibbons. 1992. The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density-lipoprotein and its response to hormones and sulphonylureas. Biochem. J. 284: 457-462.
7. Lankester, D., A. Brown, and V. Zammit. 1998. Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured hepatocytes. J. Lipid Res. 32: 1635-1645.
8. Yang, L. Y., A. Kuksis, J. J. Myher, and G. Steiner. 1995. Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: structural studies. J. Lipid Res. 36: 125-136.
9. Broadway, N., R. Pease, and E. Saggerson. 1999. Carnitine acyltransferases and associated transport processes in the endoplasmic reticulum: missing links in the VLDL story? In Current Views of Fatty Acid Oxidation and Ketogenesis: From Organelles to Point Mutations. P. Quant, and S. Eaton, editors. Kluwer Academic/Plenum Publishers, New York. 59-68.
10. Abo-Hashema, K. A., M. H. Cake, G. W. Power, and D. Clarke. 1999. Evidence for triacylglycerol synthesis in the lumen of microsomes via a lipolysis-esterification pathway involving carnitine acyltransferases. J. Biol. Chem. 274: 35577-35582.
11. Bailey, E., and E. A. Lockwood. 1973. Some aspects of fatty acid oxidation and ketone body formation and utilization during development of the rat. Enzyme. 15: 239-253.
12. Demmer, L. A., M. S. Levin, J. Elovson, M. A. Reuben, A. J. Lusis, and J. I. Gordon. 1986. Tissue-specific expression and developmental regulation of the rat apolipoprotein B gene. Proc. Natl. Acad. Sci. USA. 83: 8102-8106.
13. Jamdar, S. C., M. Moon, S. Bow, and H. J. Fallon. 1978. Hepatic lipid metabolism. Age-related changes in triglyceride metabolism. J. Lipid Res. 19: 763-770.
14. Imaizumi, K., Y. F. Lu, and M. Sugano. 1987. Characterization of serum apolipoprotein patterns in rats during suckling and post-weaning periods. Biochim. Biophys. Acta. 917: 269-278.
15. Cases, S., S. J. Smith, Y. W. Zheng, H. M. Myers, S. R. Lear, E. Sande, S. Novak, C. Collins, C. B. Welch, A.J. Lusis, S. K. Erickson, and R. V. Farese, Jr. 1998. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. USA. 95: 13018-13023.
16. Cases, S., S. Stone, P. Zhou, E. Yen, B. Tow, K. D. Lardizabal, T. Voelker, and R. V. Farese, Jr. 2001. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J. Biol. Chem. 276: 38870-38876.
17. Moir, A. M. B., and V. A. Zammit. 1993. Monitoring of changes in hepatic fatty acid and glycerolipid metabolism during the starved-to-fed transition in vivo. Studies on awake, unrestrained rats. Biochem. J. 289: 49-55.
18. Bell, R. M., L. M. Ballas, and R. A. Coleman. 1981. Lipid topogenesis. J. Lipid Res. 22: 391-403.
19. Pfaffl, M. W. 2001. A new mathematical model for the relative quantification in real-time RT-PCR. Nucleic Acids Res. 29: E45-E49.
20. Rasmussen, R. 2002. Quantification on the LightCycler. In Rapid Cycle Real-time PCR, Methods and Applications. S. Meuer, C. Wittwer, and R. Nakagawara, editors. Springer Press, Heidelberg. 21-34.
21. Coleman, R. A., E. B. Haynes, T. M. Sand, and R. A. Davis. 1988. Developmental coordinate expression of triacylglycerol and small molecular weight apoB synthesis and secretion by rat hepatocytes. J. Lipid Res. 29: 33-42).
22. Buhman, K. K., H. C. Chen, and R. V. Farese, Jr. 2001. The enzymes of neutral lipid synthesis. J. Biol. Chem. 276: 40369-40372.
23. Young, M. E., G. W. Goodwin, J. Ying, P. Guthrie, C. R. Wilson, F. A. Laws, and H. Taegtmeyer. 2001. Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. Am. J. Physiol. Endocrinol. Metab. 280: E471-E479.
24. Maziere, C., J. C. Maziere, L. Mora, M. Auclair, and J. Polonovski. 1986. Cyclic AMP increases incorporation of exogenous fatty acids into triacylglycerols in hamster fibroblasts. Lipids. 21: 525-528.
25. Lau, T. E., and M. A. Rodriguez. 1996. A protein tyrosine kinase associated with the ATP-dependent inactivation of adipose diacylglycerol acyltransferase. Lipids. 31: 277-283.
26. Frost, S. C., W. A. Clark, and M. A. Wells. 1983. Studies on fat digestion, absorption, and transport in the suckling rat. IV. In vivo rates of triacylglycerol secretion by intestine and liver. J. Lipid Res. 24: 899-903.
27. Fernando-Warnakulasuriya, G. J., M, L. Eckerson, W. A. Clark, and M. A. Wells. 1983. Lipoprotein metabolism in the suckling rat: characterization of plasma and lymphatic lipoproteins. J. Lipid Res. 24: 1626-1638.
28. Plonne, D., H-P. Schulze, U. Kahlert, K. Meltke, H. Seidolt, A. J. Bennett, I.J. Cartwright, J. A. Higgins, U. Till, and R. Dargel. 2001. Postnatal development of hepatocellular apolipoprotein B assembly and secretion in the rat. J. Lipid Res. 42: 1865-1878.
29. Douglas, D. N., V. W. Dolinsky, R. Lehner, and D. E. Vance. 2001. A role for Sp1 in the transcriptional regulation of hepatic triacylglycerol hydrolase in the mouse. J. Biol. Chem. 276: 25621-25630.
30. Coleman, R. A., and E. B. Haynes. 1984. Hepatic monoacylglycerol acyltransferase. Characterization of an activity associated with the suckling period in rats. J. Biol. Chem. 259: 8934-8938.
31. Johansson, M. B. 1983. Lipoproteins and lipids in fetal, neonatal and adult rat serum. Biol. Neonate. 44: 278-286.
32. Thumelin, S., V. Esser, D. Charvy, M. Kolodziej, V. A. Zammit, D. McGarry, J. Girard, and J. P. Pegorier. 1994. Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat. Biochem. J. 300: 583-587.
33. Lehner, R., and D. E. Vance. 1999. Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol. Biochem. J. 343: 1-10.
34. Lehner, R., Z. Cui, and D. E. Vance. 1999. Subcellullar localization, developmental expression and characterization of a liver triacylglycerol hydrolase. Biochem. J. 338: 761-768.
35. Dolinsky, V. W., S. Sipione, R. Lehner, and D. E. Vance. 2001. The cloning and expression of a murine triacylglycerol hydrolase cDNA and the structure of its corresponding gene. Biochim. Biophys. Acta. 1532: 162-172.
36. Trickett, J. I., D. D. Patel, B. L. Knight, E. D. Saggerson, G. F. Gibbons, and R. J. Pease. 2001. Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation. J. Biol. Chem. 276: 39522 39532.
37. Ferre, P., J. F. Decaux, T. Issad, and J. Girard. 1986. Changes in energy metabolism during the suckling and weaning period in the newborn. Reprod. Nutr. Dev. 26: 619-631.