-
1
-
-
0028278058
-
The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16
-
The European Polycystic Kidney Disease Consortium. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. Cell 1994; 77:881-894.
-
(1994)
Cell
, vol.77
, pp. 881-894
-
-
-
2
-
-
15844385078
-
PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
-
Mochizuki T, Wu G, Hayashi T, et al. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 1996; 272:1339-1342.
-
(1996)
Science
, vol.272
, pp. 1339-1342
-
-
Mochizuki, T.1
Wu, G.2
Hayashi, T.3
-
3
-
-
0029002967
-
Polycystic kidney disease: The complete structure of the PKD1 gene and its protein
-
The International Polycystic Kidney Disease Consortium. Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. Cell 1995; 81:289-298.
-
(1995)
Cell
, vol.81
, pp. 289-298
-
-
-
4
-
-
0030909957
-
PKD1 interacts with PKD2 through a probable coiled-coil domain
-
Qian F, Germino FJ, Cai Y, et al. PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat Genet 1997; 16:179-183.
-
(1997)
Nat Genet
, vol.16
, pp. 179-183
-
-
Qian, F.1
Germino, F.J.2
Cai, Y.3
-
5
-
-
0030979629
-
Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2
-
Tsiokas L, Kim E, Arnould T, et al. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc Natl Acad Sci U S A 1997; 94:6965-6970.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 6965-6970
-
-
Tsiokas, L.1
Kim, E.2
Arnould, T.3
-
7
-
-
0033989173
-
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
-
Wu G, Markowitz GS, Li L, et al. Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet 2000; 24:75-78.
-
(2000)
Nat Genet
, vol.24
, pp. 75-78
-
-
Wu, G.1
Markowitz, G.S.2
Li, L.3
-
8
-
-
0035504102
-
Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects
-
Lu W, Shen X, Pavlova A, et al. Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genet 2001; 10:2385-2396.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 2385-2396
-
-
Lu, W.1
Shen, X.2
Pavlova, A.3
-
9
-
-
0035834136
-
Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene
-
Boulter C, Mulroy S, Webb S, et al. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A 2001; 98:12174-12179.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12174-12179
-
-
Boulter, C.1
Mulroy, S.2
Webb, S.3
-
10
-
-
0035136996
-
Current advances in molecular genetics of autosomal-dominant polycystic kidney disease
-
Wu G. Current advances in molecular genetics of autosomal-dominant polycystic kidney disease. Curr Opin Nephrol Hypertens 2001; 10:23-31.
-
(2001)
Curr Opin Nephrol Hypertens
, vol.10
, pp. 23-31
-
-
Wu, G.1
-
11
-
-
0033635231
-
Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells
-
Boletta A, Qian F, Onuchic LF, et al. Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells. Mol Cell 2000; 6:1267-1273.
-
(2000)
Mol Cell
, vol.6
, pp. 1267-1273
-
-
Boletta, A.1
Qian, F.2
Onuchic, L.F.3
-
12
-
-
0036175934
-
The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells
-
Nickel C, Benzing T, Sellin L, et al. The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest 2002; 109:481-489.
-
(2002)
J Clin Invest
, vol.109
, pp. 481-489
-
-
Nickel, C.1
Benzing, T.2
Sellin, L.3
-
13
-
-
0030890519
-
Autosomal dominant polycystic kidney disease: A two-hit model
-
Germino GG. Autosomal dominant polycystic kidney disease: a two-hit model. Hosp Pract 1997; 32:81-102.
-
(1997)
Hosp Pract
, vol.32
, pp. 81-102
-
-
Germino, G.G.1
-
14
-
-
0035079832
-
Polycystin: New aspects of structure, function, and regulation
-
Wilson PD. Polycystin: new aspects of structure, function, and regulation. J Am Soc Nephrol 2001; 12:834-845.
-
(2001)
J Am Soc Nephrol
, vol.12
, pp. 834-845
-
-
Wilson, P.D.1
-
15
-
-
0032513031
-
The polycystic kidney disease 1 gene product mediates protein kinase C α-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1
-
Arnould T, Kim E, Tsiokas L, et al. The polycystic kidney disease 1 gene product mediates protein kinase C α-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1. J Biol Chem 1998; 273:6013-6018.
-
(1998)
J Biol Chem
, vol.273
, pp. 6013-6018
-
-
Arnould, T.1
Kim, E.2
Tsiokas, L.3
-
16
-
-
85061110808
-
Physiology, phylogeny, and functions of the TRP superfamily of cation channels
-
Montell C. Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Science's STKE. http://stke.sciencemag.org/cgi/content/full/OC_sigtrans; 2001/90/re1 [last accessed 27 June 2002].
-
Science's STKE
-
-
Montell, C.1
-
17
-
-
0037040395
-
The TRP channels, a remarkably functional family
-
Montell C, Birnbaumer L, Flockerzi V. The TRP channels, a remarkably functional family. Cell 2002; 108:595-598.
-
(2002)
Cell
, vol.108
, pp. 595-598
-
-
Montell, C.1
Birnbaumer, L.2
Flockerzi, V.3
-
18
-
-
18544369466
-
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
-
Schlingmann KP, Weber S, Peters M, et al. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 2002; 31:166-170.
-
(2002)
Nat Genet
, vol.31
, pp. 166-170
-
-
Schlingmann, K.P.1
Weber, S.2
Peters, M.3
-
19
-
-
9844245128
-
Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains
-
Sandford R, Sgotto B, Aparicio S, et al. Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. Hum Mol Genet 1997; 6:1483-1489.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 1483-1489
-
-
Sandford, R.1
Sgotto, B.2
Aparicio, S.3
-
20
-
-
0034700483
-
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
-
Hanaoka K, Qian F, Boletta A, et al. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 2000; 408:990-994.
-
(2000)
Nature
, vol.408
, pp. 990-994
-
-
Hanaoka, K.1
Qian, F.2
Boletta, A.3
-
21
-
-
0037192763
-
Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2
-
Delmas P, Nomura H, Li X, et al. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem 2002; 277:11276-11283.
-
(2002)
J Biol Chem
, vol.277
, pp. 11276-11283
-
-
Delmas, P.1
Nomura, H.2
Li, X.3
-
22
-
-
0027925829
-
Autosomal dominant polycystic kidney disease
-
Gabow PA. Autosomal dominant polycystic kidney disease. N Engl J Med 1993; 329:332-342.
-
(1993)
N Engl J Med
, vol.329
, pp. 332-342
-
-
Gabow, P.A.1
-
24
-
-
0346740202
-
Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: Mutational and functional analysis
-
Vandorpe DH, Wilhelm S, Jiang L, et al. Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis. Physiol Genomics 2002; 8:87-98.
-
(2002)
Physiol Genomics
, vol.8
, pp. 87-98
-
-
Vandorpe, D.H.1
Wilhelm, S.2
Jiang, L.3
-
25
-
-
0033598347
-
Polycystin-L is a calcium-regulated cation channel permeable to calcium ions
-
Chen XZ, Vassilev PM, Basora N, et al. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature 1999; 401:383-386.
-
(1999)
Nature
, vol.401
, pp. 383-386
-
-
Chen, X.Z.1
Vassilev, P.M.2
Basora, N.3
-
27
-
-
0037067735
-
Voltage dependence and pH regulation of human polycystin-2 mediated cation channel activity
-
in press
-
Gonzalez-Perrett S, Batelli M, Kim K, et al. Voltage dependence and pH regulation of human polycystin-2 mediated cation channel activity. J Biol Chem 2002 (in press).
-
(2002)
J Biol Chem
-
-
Gonzalez-Perrett, S.1
Batelli, M.2
Kim, K.3
-
29
-
-
0036122434
-
Polycystin-2 is an intracellular calcium release channel
-
Koulen P, Cai Y, Geng L, et al. Polycystin-2 is an intracellular calcium release channel. Nat Cell Biol 2002; 4:191-197.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 191-197
-
-
Koulen, P.1
Cai, Y.2
Geng, L.3
-
30
-
-
0034810833
-
Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X
-
Chen XZ, Segal Y, Basora N, et al. Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. Biochem Biophys Res Commun 2001; 282:1251-1256.
-
(2001)
Biochem Biophys Res Commun
, vol.282
, pp. 1251-1256
-
-
Chen, X.Z.1
Segal, Y.2
Basora, N.3
-
31
-
-
0033214702
-
Identification and characterization of polycystin-2, the PKD2 gene product
-
Cai Y, Maeda Y, Cedzich A, et al. Identification and characterization of polycystin-2, the PKD2 gene product. J Biol Chem 1999; 274:28557-28565.
-
(1999)
J Biol Chem
, vol.274
, pp. 28557-28565
-
-
Cai, Y.1
Maeda, Y.2
Cedzich, A.3
-
32
-
-
0037036350
-
Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex
-
Newby LJ, Streets AJ, Zhao Y, et al. Identification, characterization, and localization of a novel kidney polycystin-1-polycystin.2 complex. J Biol Chem 2002; 277:20763-20773.
-
(2002)
J Biol Chem
, vol.277
, pp. 20763-20773
-
-
Newby, L.J.1
Streets, A.J.2
Zhao, Y.3
-
34
-
-
0034068137
-
2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the β subunit
-
2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the β subunit. Neuron 2000; 25:177-190.
-
(2000)
Neuron
, vol.25
, pp. 177-190
-
-
Bichet, D.1
Cornet, V.2
Geib, S.3
-
35
-
-
0033616720
-
Specific association of the gene product of PKD2 with the TRPC1 channel
-
Tsiokas L, Arnould T, Zhu C, et al. Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci U S A 1999; 96:3934-3939.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3934-3939
-
-
Tsiokas, L.1
Arnould, T.2
Zhu, C.3
-
36
-
-
0034750946
-
Molecular biology of protein kinase C signaling in cardiac myocytes
-
Malhotra A, Kang BP, Opawumi D, et al. Molecular biology of protein kinase C signaling in cardiac myocytes. Mol Cell Biochem 2001; 225:97-107.
-
(2001)
Mol Cell Biochem
, vol.225
, pp. 97-107
-
-
Malhotra, A.1
Kang, B.P.2
Opawumi, D.3
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