Short-term suppression of GH and IGF-I levels improves gonadal function and sperm parameters in men with acromegaly

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 9, 2002, Pages 4193-4197

  Colao, A ^a,b   De Rosa, M ^a,b   Pivonello, R ^a,b   Balestrieri, A ^a,b   Cappabianca, P ^a,b   Di Sarno, A ^a,b   Rochira, V ^a,b   Carani, C ^a,b   Lombardi, G ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ANGIOPEPTIN; FOLLITROPIN; GLUCOSE; GROWTH HORMONE; SOMATOMEDIN C; TESTOSTERONE;

ACROMEGALY; ADULT; AGE; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EVALUATION; GONAD FUNCTION; HORMONAL REGULATION; HORMONAL THERAPY; HUMAN; MALE; PRIORITY JOURNAL; REPRODUCTION; SEMEN ANALYSIS; SEMINAL PLASMA; SEX HORMONE DETERMINATION; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SPERMATOZOON PENETRATION; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL; TREATMENT OUTCOME;

ACROMEGALY; ADENOMA; ADULT; ANDROGEN ANTAGONISTS; DIHYDROTESTOSTERONE; DISEASE PROGRESSION; ESTRADIOL; FOLLICLE STIMULATING HORMONE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LUTEINIZING HORMONE; MALE; MIDDLE AGED; PEPTIDES, CYCLIC; PITUITARY NEOPLASMS; REGRESSION ANALYSIS; SOMATOSTATIN; SPERM COUNT; SPERM MOTILITY; TESTOSTERONE;

EID: 0036736808     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020453     Document Type: Article

References (27)

1. Kaltsas AG, Mukherjee JJ, Jenkins PJ, Satta MA, Islam N, Monson JP, Besser GM, Grossman AB 1999 Menstrual irregularity in women with acromegaly. J Clin Endocrinol Metab 84:2731-2735
2. Melmed S, Ho K, Klibanski A, Reichlin S, Thorner MO 1995 Recent advances in pathogenesis, diagnosis and management of acromegaly. J Clin Endocrinol Metab 80:3395-3402
3. Colao A, Merola B, Ferone D, Lombardi G 1997 Acromegaly. J Clin Endocrinol Metab 82:2777-2781
4. Lin T, Wang D, Calkins JH, Guo H, Chi R, Housley PR 1990 Regulation of insulin-like growth factor-I messenger ribonucleic acid expression in Leydig cells. Mol Cell Endocrinol 73:147-152
5. Naville D, Chatelain PG, Avallet O, Saez GM 1990 Control of production of insulin-like growth factor-I by pig Leydig and Sertoli cells cultured alone or together. Cell-cell interactions. Mol Cell Endocrinol 70:217-224
6. Barlett JMS, Charlton HM, Robison ICAF, Nieschlag E 1990 Pubertal development and testicular function in the GH-deficient rat. J Endocrinol 126:193-201
7. Spiteri-Grech J, Barlett JMS, Nieschlag E 1991 Regulation of testicular insulin-like growth factor-I in pubertal growth hormone-deficient male rats. J Endocrinol 131:279-285
8. Shoham Z, Zalel Y, Jacobs SH 1994 The role of growth hormone in male infertility. Clin Endocrinol 41:1-5
9. Carani C, Granata AR, De Rosa M, Garau C, Zarrilli S, Paesano L, Colao A, Marrama P, Lombardi G 1999 The effect of chronic treatment With GH on gonadal function in men with isolated GH deficiency. Eur J Endocrinol 140:224-230
10. Colao A, Marzullo P, Spiezia S, Ferone D, Giaccio A, Cerbone G, Pivonello R, Di Somma C, Lombardi G 1999 Effect of growth hormone (GH) and insulin-like growth factor-1 on prostate diseases: an ultrasonographic and endocrine study in acromegaly, GH-deficiency and healthy subjects. J Clin Endocrinol Metab 84:1986-1991
11. Colao A, Marzullo P, Ferone D, Spiezia S, Cerbone G, Marino V, Di Sarno A, Merola B, Lombardi G 1998 Prostate hyperplasia: an unknown feature of acromegaly. J Clin Endocrinol Metab 83:775-779
12. Colao A, Lombardi G 1998 GH and PRL excess. Lancet 352:1455-1461
13. Colao A, Ferone D, Cappabianca P, del Basso De Caro ML, Marzullo P, Monticelli A, Alfieri A, Merola B, Cali A, de Divitiis E, Lombardi G 1997 Effect of octreotide pretreatment on surgical outcome in acromegaly. J Clin Endocrinol Metab 82:3308-3314
14. Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, Ho K, Veldhuis J, Wass J, Von Werder K, Melmed S 2000 Criteria for cure of acromegaly: a consensus statement. J Clin Endocrinol Metab 85:526-529
15. Carter JN, Tyson JE, Tolis G, Van Vliet S, Faiman C, Friesen HG 1978 Prolactin-secreting tumors and hypogonadism in 22 men. N Engl J Med 299:847-852
16. Segal S, Yaffe H, Laufer N, Ben-David M 1979 Male hyperprolactinemia: effects in fertility. Fertil Steril 32:556-561
17. Colao A, De Rosa M, Sarnacchiaro F, Di Sarno A, Landi ML, Iervolino E, Zarrilli S, Merola B, Lombardi G 1996 Chronic treatment with CV 205-502 restores the gonadal function in hyperprolactinemic males. Eur J Endocrinol 135:548-552
18. De Rosa M, Colao A, Di Sarno A, Ferone D, Landi ML, Zarrilli S, Paesano L, Merola B, Lombardi G 1998 Cabergoline treatment rapidly improved gonadal function in hyperprolactinemic males: a comparison with bromocriptine. Eur J Endocrinol 138:286-293
19. Colao A, Marzullo P, Ferone D, Marino V, Pivonello R, Di Somma C, Di Sarno A, Giaccio A, Lombardi G 1999 Effectiveness and tolerability of slow release lanreotide treatment in active acromegaly. J Endocrinol Invest 22:40-47
20. Baldelli R, Colao A, Razzore P, Jaffrain-Rea ML, Marzullo P, Ciccarelli E, Ferretti E, Ferone D, Gaia D, Camanni F, Lombardi G, Tamburrano G 2000 Two-year follow-up of acromegalic patients treated with sr-lanreotide 30 mg. J Clin Endocrinol Metab 85:4099-4103
21. 1999 WHO Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. Cambridge: Cambridge University Press
22. Mathews LS, Enberg B, Norstedt G 1989 Regulation of rat hormone receptor gene expression. J Biol Chem 264:9905-9910
23. Söder O, Bang P, Wahab A, Parvinen M 1992 Insulin-like growth factors selectively stimulate spermatogonial, but not meiotic, deoxyribonucleic acid synthesis during rat spermatogenesis. Endocrinology 131:2344-2350
24. Spitery-Grech J, Nieschlag E 1992 The role of growth hormone and insulin-like growth factor I in the regulation of male reproductive function. Horm Res 38(Suppl 1):22-27
25. Zipt WB, Payne AH, Kelch RP 1978 Prolactin, growth hormone and luteinizing hormone in the maintenance of testicular luteinizing receptors. Endocrinology 103:595-600
26. Sjögren I, Joussou M, Madej A, Johansson HE, Plöen L 1998 Effects of very high doses of human growth hormone (hGH) on the male reproductive system in the dog. Andrologia 30:37-42
27. Colao A, Marzullo P, Spiezia S, Giaccio A, Ferone D, Cerbone G, Di Sarno A, Lombardi G 2000 Effect of two years of growth hormone/insulin-like growth factor-I suppression on prostate diseases in acromegalic patients. J Clin Endocrinol Metab 85:3754-3761