Epidemic pathogenic selection: An explanation for hereditary hemochromatosis?

Medical Hypotheses

Volumn 59, Issue 3, 2002, Pages 325-329

  Moalem, Sharon ^a   Percy, Maire E ^b   Kruck, Theo P A ^c   Gelbart, Richard R ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c YORK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; HFE PROTEIN; IRON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN; TYROSINE;

AMINO ACID SUBSTITUTION; CELL SURFACE; EPIDEMIC; EUROPE; GENE; GENETIC DISORDER; HEMOCHROMATOSIS; HFE GENE; HOMOZYGOSITY; HUMAN; INFECTION; INTESTINE; IRON OVERLOAD; MACROPHAGE; MUTATION; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; YERSINIA;

YERSINIA;

EID: 0036734286     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(02)00179-2     Document Type: Article

References (37)

1. Tay-Sachs disease carrier screening: A model forprevention of genetic disease
2. Human mitochondrial diseases: Answering questions and questioning answers
3. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
4. HFE mutations analysis in 711 hemochromatosis probands: Evidence for S65C implication in mild form of hemochromatosis
5. Two novel missense mutations of the HFE mutation in Alabama hemochromatosis probands
6. Hemochromatosis: A genetic defect in iron metabolism
7. Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis
8. Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis
9. Association of HFE protein with transferrin receptor in crypt emerocytes of human duodenum
10. Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: Implications for cellular iron homeostasis
11. The hemochromatosis founder mutation in HLA-H disrupts beta2- microglobulin interaction and cell surface expression
12. Current concepts in mucosal immunity. II. One size fits all: Nonclassical MHC molecules fulfill multiple roles in epithelial cell function
13. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
14. Nramp1: A link between intracellular iron transport and innate resistance to intracellular pathogens
15. The Nramp1 protein and its role in resistance to infection and macrophage function
16. Prevalence of the C282Y and H63D polymorphisms in a multi-ethnic control population
17. The genetics of hemochromatosis
18. Prevalence of hereditary hemochromatosis in a Massachusetts corporation: Is Celtic origin a risk factor?
19. Multicentric origin of hemochromatosis gene (HFE) mutations
20. Global prevalence of putative haemochromatosis mutations
21. Bubonic plague: A molecular genetic case history of the emergence of an infectious disease
22. Yersinia enterocolitica: The charisma continues
23. Iron overload disorders: Natural history, pathogenesis, diagnosis, and therapy
24. Yersinia enterocolitica infections
25. Haplotype analysis of hemochromatosis: Evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes
26. Plague mortality and demographic depression in later medieval England
27. Celtic origin of the C282Y mutation of hemochromatosis
28. An anatomy of an epidemic: Colyton, November 1645 to November 1646
29. Salmonellosis: Host immune responses and bacterial virulence determinants
30. Salmonella typhi uses CFTR to enter intestinal epithelial cells
31. Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1
32. Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7
33. Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation
34. Haldane (1949) on infectious disease and evolution
35. Protection afforded by sickle cell trail against sub-tertian malarial infection
36. Immunogenetics: Soaring costs in defense