Sevoflurane low-flow anaesthesia: Best strategy to reduce Compound A concentration

Acta Anaesthesiologica Scandinavica

Volumn 46, Issue 8, 2002, Pages 1017-1020

  Di Filippo, A ^a   Marini, F ^a   Pacenti, M ^b   Dugheri, S ^b   Focardi, L ^b   Novelli, G P ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Unit of Occupational Preventive Medicine   (Italy)

Author keywords

Anesthesia machine; Compound A; Low flow anesthesia; Sevoflurane

Indexed keywords

2,2 DIFLUORO 1 (TRIFLUOROMETHYL)VINYL FLUOROMETHYL ETHER; ABSORBENT; AMSORB; DRAGERSORB 800 PLUS; POTASSIUM HYDROXIDE; SEVOFLURANE; SODIUM CARBONATE; SODIUM HYDROXIDE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANESTHESIA LEVEL; ANESTHETIC EQUIPMENT; ARTICLE; GENERAL ANESTHESIA; IN VITRO STUDY; PRIORITY JOURNAL;

ABSORPTION; ANESTHESIA, CLOSED-CIRCUIT; ANESTHETICS, INHALATION; CARBON DIOXIDE; ETHERS; HUMANS; HYDROCARBONS, FLUORINATED; METHYL ETHERS;

EID: 0036724372     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2002.460815.x     Document Type: Article

References (16)

1. Reaction of Sevoflurane and its degradation products with soda lime
2. Toxicity of Compound A in rats
3. Factors affecting the concentration of Compound A resulting from the degradation of Sevoflurane by soda lime and baralyme in a standard anesthetic circuit
4. Amsorb. A new carbon dioxide absorber for use in anesthetic breathing system
5. Comparison of Compound A concentrations with Sevoflurane anaesthesia using a closed system with a PhysioFlex anaesthesia machine vs a low flow system with a conventional anaesthesia machine
6. In vitro Compound A formation in a computer-controlled closed circuit anesthetic apparatus
7. Dose-related biochemical markers of renal injury after Sevoflurane versus Desflurane anaesthesia in volunteers
8. Cysteine conjugate β-lyase-dependent metabolism of Compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given Compound A
9. Nephrotoxicity of sevoflurane versus desflurane anaesthesia in volunteers
10. Dose of Compound A, not Sevoflurane, determines changes in the biochemical markers of renal injury in healthy volunteers
11. Amsorb reduces the Compound A production in vitro and clinical results
12. The elimination of sodium and potassium hydroxides from desiccated soda lime diminishes degradation of desflurane to carbon monoxide and sevoflurane to Compound A but does not compromise carbon dioxide absorption
13. Compound A concentrations during low flow sevoflurane anaesthesia correlate directly with the concentration of monovalent bases in carbon dioxide absorbers
14. Absorbers differ enormously in their capacity to produce Compound A and carbon monoxide
15. Carbon dioxide absorbers containing potassium hydroxide produce much larger concentrations of Compound A from Sevoflurane in clinical practice
16. Fresh gas utilization of eight circle systems