Transcriptional repression of the rat osteocalcin gene by δEF1

Endocrinology

Volumn 143, Issue 9, 2002, Pages 3370-3375

  Sooy, Karen ^a   Demay, Marie B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; MESSENGER RNA; OLIGONUCLEOTIDE; OSTEOCALCIN; PYRIMIDINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DELTA EF1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; ENZYME ACTIVITY; FUSION GENE; GENE OVEREXPRESSION; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; INTRON; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RAT; SILENCER GENE;

ANIMALS; BINDING SITES; CELL LINE; COS CELLS; DNA; GENE EXPRESSION; GENES, REPORTER; HOMEODOMAIN PROTEINS; INTRONS; LUCIFERASES; MUTAGENESIS, SITE-DIRECTED; OSTEOBLASTS; OSTEOCALCIN; POINT MUTATION; PROMOTER REGIONS (GENETICS); RATS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0036721589     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2001-211441     Document Type: Article

References (28)

1. Osteocalcin and matrix gla protein: Vitamin K dependent proteins in bone
2. Increased bone formation in osteocalcin deficient mice
3. 3 on gene transcription
4. A PEBP2a/AML1 related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element
5. Msx-2/Hox8.1: A transcriptional regulator of the rat osteocalcin promoter
6. Transcriptional control of the tissue-specific developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins
7. Stage specific expression of Dlx5 during osteoblast differentiation: Involvement in regulation of osteocalcin gene expression
8. YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene
9. Role of the negative glucocorticoid regulatory element in glucocorticoid repression of the human osteocalcin promoter
10. Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription
11. 3 and tumor necrosis factor-α in the rat osteocalcin gene
12. Position and orientation selective silencer in protein coding sequences of the rat osteocalcin gene
13. A complete intragenic silencer domain exhibits negative and positive transcriptional control of the bone-specific osteocalcin gene: Promoter and cell type requirements
14. Transcriptional repression of the rat osteocalcin gene: Role of two intronic CCTCCT motifs
15. δEF1 binds to a far-upstream sequence of the mouse pro-α1(I) collagen gene and represses its expression in osteoblasts
16. The transcription factor δEF1 is inversely expressed with type II collagen mRNA and can repress Col2a1 promoter activity in transfected chondrocytes
17. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
18. The δ crystallin enhancer-binding protein δEF1 is a repressor of E2 box mediated gene activation
19. Parathyroid hormone-responsive clonal cell lines from a rat osteosarcoma
20. Identification of an osteoblastic silencer element in the first intron of the rat osteocalcin gene
21. Identification of nuclear factor δEF1 and its binding site essential for lens-specific activity of the δ1-crystallin enhancer
22. δ-crystallin enhancer binding protein δEF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis
23. Organization of the gene encoding transcriptional repressor δEF1 and cross-species conservation of its domains
24. Overlapping positive and negative regulatory elements determine lens-specific activation of the δ1-crystallin enhancer
25. Impairment of T cell development in δEF1 mutant mice
26. δEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages
27. Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic-protein induced osteogenic differentiation of C2C12 cells