Stimulation of hypoxia-inducible factor-1 alpha (HIF-1α) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1α messenger RNA expression

Biology of Reproduction

Volumn 67, Issue 3, 2002, Pages 995-1002

  Powell, John D ^a   Elshtein, Ronit ^a   Forest, Daniel J ^a   Palladino, Michael A ^a  

^a MONMOUTH UNIVERSITY   (United States)

Author keywords

Epididymis; Gene regulation; Male reproductive tract; Stress; Testis

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROTEASOME;

ACCESSORY SEX GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; EPIDIDYMIS; GENE CONTROL; HYPOXIA; IMMUNOBLOTTING; ISCHEMIA; MALE; MALE GENITAL SYSTEM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT; REPERFUSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE; STRESS; TESTIS INJURY; TESTIS TORSION;

ANIMALS; EPIDIDYMIS; GENE EXPRESSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISCHEMIA; KINETICS; MALE; PENIS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPERMATIC CORD TORSION; TESTIS; TRANSCRIPTION FACTORS; VAS DEFERENS;

ANIMALIA;

EID: 0036720753     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.101.002576     Document Type: Article

References (49)

1. Unilateral neonatal testicular torsion
2. Torsion of the testis
3. Spermatic cord torsion: Loss of spermatogenesis despite return of blood flow
4. Acute testicular ischemia results in germ cell-specific apoptosis in the rat
5. Testicular torsion: Time is the enemy
6. Leydig cell function after experimental testicular torsion despite loss of spermatogenesis
7. On the synthesis and secretion of rat seminiferous tubule proteins in vivo after ischemia and germ cell loss
8. Spermatogenesis in rat testis after experimental ischemia
9. Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis
10. Germ cell apoptosis and endothelial nitric oxide synthase (eNOS) expression following ischemia-reperfusion injury to testis
11. Essential role of neutrophils in germ cell-specific apoptosis following ischemia/reperfusion injury of the mouse testis
12. Mammalian oxygen sensing, signalling and gene regulation
13. HIF-1 and mechanisms of oxygen sensing
14. 2 homeostasis by hypoxia-inducible factor 1
15. Oxygen regulation of gene expression: A study in opposites
16. HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
17. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
18. HIF-1 and human disease: One highly involved factor
19. Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis
20. Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease
21. Mouse hypoxia-inducible factor-1alpha is encoded by two different mRNA isoforms: Expression from a tissue-specific and a housekeeping-type promoter
22. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
23. 2 sensing
24. Induction of HIF-1 alpha in response to hypoxia is instantaneous
25. Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1 alpha
26. Increased expression of hypoxia inducible factor-1α in rat and human prostate cancer
27. Cleavage of structural protein during the assembly of the head of bacteriophage T4
28. p43/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
29. 2 homeostasis
30. Molecular characterization of the murine Hif-1 alpha locus
31. Cardiac expressions of HIF-1α and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptive responses to hypoxic stresses
32. The mouse gene for hypoxia-inducible factor-1alphagenomic organization, expression and characterization of an alternative first exon and 5′ flanking sequence
33. Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis
34. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1
35. ERK activation upon hypoxia: Involvement in HIF-1 activation
36. A conserved family of prolyl-4-hydroxylases that modify HIF
37. Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
38. Metal-catalyzed oxidation of proteins. Physiological consequences
39. Fluctuations in rat testicular interstitial oxygen tensions are linked to testicular vasomotion: Persistence after repair of torsion
40. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
41. Testicular tissue specific expression of the p53 suppressor gene
42. Expression of Bcl-2 family proteins and spontaneous apoptosis in normal human testis
43. Human Cu/Zn superoxide dismutase gene: Molecular characterization of its two mRNA species
44. Stabilization of wild-type p53 by hypoxia-inducible factor 1α
45. Dephosphorylated hypoxia-inducible factor lalpha as a mediator of p53-dependent apoptosis during hypoxia
46. Structure of the 5′ region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA
47. Characterization of rat transferrin receptor cDNA: The regulation of transferrin receptor mRNA in testes and in Sertoli cells in culture
48. Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1