Interaction of topotecan, DNA topoisomerase I inhibitor, with double-stranded polydeoxyribonucleotides. 4. Topotecan binds preferably to the GC base pairs of DNA;Vzaimodeistvie topotekana--ingibitora DNK-topoizomerazy I--s dvunitevymi polidezoksiribonukleotidami. IV. Topotekan sviazyvaetsia preimushchestvenno s GC-parami osnovanii DNK.

Molekuliarnaia biologiia

Volumn 36, Issue 5, 2002, Pages 912-930

  Strel'tsov, S A ^a   Mikheikin, A L ^a   Grokhovskii, S L ^a   Oleinikov, V A ^a   Kudelina, I A ^a   Zhuze, A L ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA TOPOISOMERASE; ENZYME INHIBITOR; POLYDEOXYRIBONUCLEOTIDE; TOPOTECAN;

ARTICLE; BASE PAIRING; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATION; DRUG ANTAGONISM; METABOLISM; OSMOLARITY; RAMAN SPECTROMETRY; SOLUTION AND SOLUBILITY;

BASE PAIRING; BINDING SITES; CIRCULAR DICHROISM; DNA; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OSMOLAR CONCENTRATION; POLYDEOXYRIBONUCLEOTIDES; SOLUTIONS; SPECTRUM ANALYSIS, RAMAN; TOPOTECAN;

EID: 0036717276     PISSN: 00268984     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)