Low expression of truncated Aα chain variant in circulating fibrinogen

Thrombosis and Haemostasis

Volumn 88, Issue 3, 2002, Pages 533-534

  Brennan, Stephen O ^a   Homer, Vivienne M ^a   Ockelford, Paul ^a   George, Peter M ^a  

^a CANTERBURY HEALTH LABORATORIES   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; FIBRINOGEN; FIBRINOGEN VARIANT;

ADULT; ALPHA CHAIN; ANAMNESIS; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXON; FIBRIN POLYMERIZATION; FIBRINOGEN DEFECT; GENE MUTATION; GENE SEQUENCE; HEMATOMA; HUMAN; LETTER; MALE; PLOTS AND CURVES; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TURBIDITY; GENETIC VARIABILITY; GENETICS; HETEROZYGOTE; METABOLISM; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE;

DNA MUTATIONAL ANALYSIS; FIBRINOGENS, ABNORMAL; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; MUTATION; VARIATION (GENETICS);

EID: 0036712244     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613248     Document Type: Letter

References (6)

1. Fibrinogen Lincoln: A new mutation causing α chain truncation and defective polymerisation
2. Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (Aα20 Val→Asp)
3. Decreased lateral aggregation of a variant recombinant fibrinogen provides insights into the polymerisation mechanism
4. Electrospray ionisation analysis of human fibrinogen
5. Homozygous truncation of the fibrinogen Aα chain within the coiled coil causes congenital afibrinogenaemia
6. Role of the αC domains of fibrin in clot formation