Stage-specific promoter activity from stably maintained episomes in Plasmodium falciparum

International Journal for Parasitology

Volumn 32, Issue 10, 2002, Pages 1203-1206

  Horrocks, Paul ^a   Pinches, Robert ^a   Kriek, Neline ^a   Newbold, Chris ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Plasmodium falciparum; Transcriptional regulation; Transfection

Indexed keywords

PLASMID DNA;

PLASMID;

ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA TRANSFECTION; EPISOME; HOMOLOGOUS RECOMBINATION; NONHUMAN; NUCLEOSOME; PLASMID; PLASMODIUM FALCIPARUM; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION REGULATION;

ANIMALS; CELLS, CULTURED; DRUG RESISTANCE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIFE CYCLE STAGES; MODELS, GENETIC; NUCLEOSOMES; PLASMIDS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROMOTER REGIONS (GENETICS); PROTEINS;

PLASMODIUM FALCIPARUM;

EID: 0036710659     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(02)00123-6     Document Type: Article

References (18)

1. Cary C., Lamont D., Dalton J.P., Doerig C. Plasmodium falciparum chromatin, nucleosomal organisation and histone-like proteins. Parasitol. Res. 80:1994;255-258.
2. Deitsch K.W., Calderwood M.S., Wellems T.E. Malaria. Cooperative silencing elements in var genes. Nature. 412:2001;875-876.
3. Horrocks P., Dechering K., Lanzer M. Control of gene expression in Plasmodium falciparum. Mol. Biochem. Parasitol. 95:1998;171-181.
4. Horrocks P., Lanzer M. Differences in nucleosome organisation over episomally located plasmids coincides with aberrant promoter activity in P. falciparum. Parasitol. Int. 48:1999;55-61.
5. Horrocks P., Pinches R., Kyes S., Kriek N., Lee S., Christodoulou Z., Newbold C. Effect of var gene disruption on switching in Plasmodium falciparum. Mol. Microbiol. 2002;. (in press).
6. Kirchmaier A.L., Rine J. DNA replication independent silencing in S. cerevisiae. Science. 291:2001;646-650.
7. Kocken C.H., van der Wel A.M., Dubbeld M.A., Narum D.L., van de Rijke F.M., van Gemert G.J., van der Linde X., Bannister L.H., Janse C., Waters A.P., Thomas A.W. Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localization. J. Biol. Chem. 273:1998;15119-15124.
8. Kornberg R.D., Lorch Y. Interplay between chromatin structure and transcription. Curr. Opin. Cell Biol. 7:1995;371-375.
9. Kornberg R.D., Lorch Y. Chromatin-modifying and -remodeling complexes. Curr. Opin. Genet. Dev. 9:1999;148-151.
10. Kyes S., Pinches R., Newbold C. A simple RNA analysis method shows var and rif multigene family expression patterns in Plasmodium falciparum. Mol. Biochem. Parasitol. 105:2000;311-315.
11. Lanzer M., de Bruin D., Ravetch J.V. Transcription mapping of a 100 kb locus of Plasmodium falciparum identifies an intergenic region in which transcription terminates and reinitiates. EMBO J. 11:1992;1949-1955.
12. Lanzer M., Wertheimer S.P., de Bruin D., Ravetch J.V. Chromatin structure determines the sites of chromosome breakages in Plasmodium falciparum. Nucleic Acids Res. 22:1994;3099-3103.
13. Li Y.-C., Cheng T.-H., Gartenberg M.R. Establishment of transcriptional silencing in the absence of DNA replication. Science. 291:2001;650-653.
14. Pace T., Scotti R., Janse C.J., Waters A.P., Birago C., Ponzi M. Targeted terminal deletions as a tool for functional genomics in Plasmodium. Genome Res. 10:2000;1414-1420.
15. Triglia T., Healer J., Caruana S.R., Hodder A.N., Anders R.F., Crabb B.S., Cowman A.F. Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species. Mol. Microbiol. 38:(4):2000;706-718.
16. Wesseling J.G., Snijders P.J., van Someren P., Jansen J., Smits M.A., Schoenmakers J.G. Stage-specific expression and genomic organization of the actin genes of the malaria parasite Plasmodium falciparum. Mol. Biochem. Parasitol. 35:1989;167-176.
17. Wolffe A. Chromatin Structure and Function. 1998;Academic Press, London.
18. Wu Y., Kirkman L.A., Wellems T.E. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc. Natl Acad. Sci. USA. 93:1996;1130-1134.