Sympatholytic properties of several AT1-receptor antagonists in the isolated rabbit thoracic aorta

Journal of Hypertension

Volumn 20, Issue 9, 2002, Pages 1821-1828

  Nap, Alexander ^a   Balt, Jippe C ^a   Pfaffendorf, Martin ^a   Van Zwieten, Pieter A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Angiotensin II; AT1 receptor antagonists; Noradrenaline; Rabbit aorta; Sympathetic transmission; Tritium

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; IRBESARTAN; LOSARTAN; TELMISARTAN; ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; BIPHENYL DERIVATIVE; NORADRENALIN; TETRAZOLE DERIVATIVE;

ADRENERGIC ACTIVITY; ADRENERGIC RECEPTOR BLOCKING; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ELECTROSTIMULATION; ISOTOPE LABELING; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RABBIT; THORACIC AORTA; ADRENERGIC SYSTEM; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; INNERVATION; METABOLISM; OSMOLARITY; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

ANGIOTENSIN II; ANIMALS; AORTA, THORACIC; BENZIMIDAZOLES; BENZOATES; BIPHENYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; LOSARTAN; NOREPINEPHRINE; OSMOLAR CONCENTRATION; RABBITS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOLYTICS; SYNAPTIC TRANSMISSION; TETRAZOLES;

EID: 0036708574     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200209000-00028     Document Type: Article

References (43)

1. Biological functions of angiotensin and its receptors
2. The angiotensin II receptor and the actions of angiotensin II
3. Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells
4. Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (All-1) and PD123177 (All-2)
5. Effect of losartan, a nonpeptide angioten. Sin II receptor antagonist, on drinking behavior and renal actions of centrally administered renin
6. Implications of local angiotensin production in cardiovascular physiology and pharmacology
7. Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure
8. Interaction between the renin-angiotensin-aldosterone and sympathetic nervous systems
9. Interaction between the adrenergic and renin-angiotensin-aldosterone systems
10. Evidence for the involvement of different receptor subtypes in the pre- and postjunctional actions of angiotensin II at rat sympathetic neuroeffector sites
11. Angiotensin II receptors involved in the enhancement of noradrenergic transmission in the caudal artery of the spontaneously hypertensive rat
12. Multiple prejunctional actions of angiotensin II on noradrenergic transmission in the caudal artery of the rat
13. Different receptors for angiotensin II at pre- and postjunctional level of the canine mesenteric and pulmonary arteries
14. Differential inhibition of the prejunctional actions of angiotensin II in rat atria by valsartan, irbesartan, eprosartan, and losartan
15. Prejunctional modulation by angiotensins of noradrenaline release from sympathetic neurons in isolated rabbit aorta
16. The sympathetic nervous system in hypertension: A potential long-term regulator of arterial pressure
17. The sympathetic nervous system in chronic heart failure
18. Clinical aspects of sympathetic activation and parasympathetic withdrawal in heart failure
19. Subclasses of angiotensin II binding sites and their functional significance
20. Preliminary biochemical characterization of two angiotensin II receptor subtypes
21. Angiotensin II receptor subtypes and their selective nonpeptide ligands
22. Angiotensin II type 1 receptor blockers
23. Angiotensin II increases norepinephrine release from atria by acting on angiotensin subtype 1 receptors
24. Characterization of angiotensin receptors mediating the neuromodulatory effects of angiotensin in the vas deferens of the rabbit
25. The effect of isoprotenerol on neurotransmission in the rat mesenteric artery
26. Differential effects of eprosartan and losartan at prejunctional angiotensin II receptors
27. Inhibition of facilitation of sympathetic neurotransmission and angiotensin II-induced pressor effects in the pithed rat: Comparison between valsartan, candesartan, eprosartan and embusartan
28. Effect of the AT1-receptor antagonists losartan, irbesartan, and telmisartan on angiotensin II-induced facilitation of sympathetic neurotransmission in the rat mesenteric artery
29. Inhibition of angiotensin II-induced facilitation of sympathetic neurotransmission in the pithed rat: A comparison between losartan, irbesartan, telmisartan, and captopril
30. Inhibition of sympathetic outflow by the angiotensin II receptor antagonist, eprosartan, but not by losartan, valsartan or irbesartan: Relationship to differences in prejunctional angiotensin II receptor blockade
31. Characterisation of a modified approach to the study of sympathetic neurotransmission and its presynaptic modulation in the isolated rabbit thoracic aorta
32. Interrelations between prostaglandins and vasoconstrictor hormones: Contribution to blood pressure regulation
33. Attenuation by prostaglandins of the facilitatory effect of angiotensin II at adrenergic prejunctional sites in the isolated Krebs-perfused rat heart
34. Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney
35. Interactions between angiotensin II, sympathetic nerve-mediated pressor response and cyclo-oxygenase products in the pithed rat
36. Sympathoinhibitory effects of losartan in spontaneously hypertensive rats
37. Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function
38. Effects of irbesartan (SR47436/BMS-186295) on angiotensin II-induced pressor responses in the pithed rat: Potential mechanisms of action
39. Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist
40. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277
41. Pharmacokinetics and pharmacodynamics of irbesartan in healthy subjects
42. Telmisartan
43. Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans