Time-dependent cardioprotection with calcium antagonism and experimental studies with clevidipine in ischemic-reperfused pig hearts: Part II

Journal of Cardiovascular Pharmacology

Volumn 40, Issue 3, 2002, Pages 339-345

  Segawa, Daisuke ^a   Sjöquist, Per Ove ^a   Wang, Qing Dong ^a   Gonon, Adrian ^a   Rydén, Lars ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Calcium antagonist; Dihydropyridine; Ischemia; Pig; Reperfusion injury; Ultrashort acting drug

Indexed keywords

CALCIUM; CALCIUM ANTAGONIST; CLEVIDIPINE; EVANS BLUE; PENTOBARBITAL; TRIPHENYLTETRAZOLIUM; CARDIOTONIC AGENT; PYRIDINE DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHRONOTHERAPY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; FEMALE; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE FIBRILLATION; HEMODYNAMICS; MALE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; SWINE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; HEART INFARCTION; METABOLISM; PATHOPHYSIOLOGY; TIME;

ANIMAL; CALCIUM; CARDIOTONIC AGENTS; CORONARY CIRCULATION; FEMALE; HEMODYNAMICS; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; PYRIDINES; SWINE; TIME FACTORS; VENTRICULAR FIBRILLATION; ANIMALS; HEMODYNAMIC PROCESSES;

EID: 0036708253     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200209000-00002     Document Type: Article

References (31)

1. 2+ overload in reperfused ischemic myocardium
2. Mechanism of myocardial stunning
3. Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at onset of reperfusion
4. Prevention of reperfusion damage in working rat hearts by calcium antagonists and calmodulin antagonists
5. Diltiazem and progression of myocardial ischemic damage during coronary artery occlusion and reperfusion in porcine hearts
6. Effect of verapamil on postischemic "stunned" myocardium: Importance of the timing of treat
7. Effects of nisoldipine on the no-reflow phenomenon in globally ischemic rat hearts
8. The calcium antagonists nisoldipine improves the functional recovery of reperfused myocardium only when given before ischemia
9. Protective effects of benidipine against myocardial damage following ischemia and reperfusion in the isolated perfused rat heart
10. Preischemic as well as postischemic application of a calcium antagonist affords cardioprotection in the isolated guinea pig heart
11. Calcium antagonists and the stunned myocardium: A role during ischemia? A role during reperfusion?
12. Coronary venous retroinfusion of felodipine reduces myocardial necrosis after coronary occlusion and reperfusion
13. Coronary venous retroinfusion of felodipine reducing infarct size without affecting regional myocardial blood flow
14. Role of calcium and other ions in reperfusion injury
15. Reperfusion induced arrhythmias following ischemia in intact rat heart: Role of intracellular calcium
16. Ionic basis of ischemic cardiac injury: Insight from cellular studies
17. Pharmacokinetics and pharmacodynamics of clevidipine in healthy volunteers after intravenous infusion
18. In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man
19. The effects of calcium channel antagonist treatment and oxygen radical scavenging on infarct size and the no-reflow phenomenon in reperfused heart
20. Timely administration of nisoldipine essential for prevention of myocardial ATP catabolism
21. Effects of a calcium-entry blocker (diltiazem) on regional myocardial flow and function during exercise in conscious dogs
22. Cardioprotection by nisoldipine: Role of timing of administration
23. Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells. Correlation of protection with preservation of glutathione levels
24. 2+
25. Time-dependent cardioprotection with calcium antagonism-experimental studies with clevidipine in ischemic-reperfused pig hearts. I: Coronary venous and arterial concentrations of clevidipine, an ultrashort-acting calcium antagonist after intracoronary infusion into ischemic and non-ischemic pig hearts
26. The pharmacokinetics of a new calcium channel antagonist clevidipine in the rat, rabbit and dog and the PK/PD relationship in anesthetized dogs
27. Calcium antagonist protects the myocardium from reperfusion injury by interfering with mechanisms directly related to reperfusion: An experimental study with the ultrashort-acting calcium antagonist clevidipine
28. Short-term low dose intracoronary diltiazem administered at the onset of reperfusion reduces myocardial infarct size
29. ++ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts
30. ++ in early and late reperfused myocardium
31. Regulation of calcium slow channels of cardiac muscle by cyclic nucleotides and phosphorylation