Preparation of 99mTc-C60(OH)x and its biodistribution studies

Nuclear Medicine and Biology

Volumn 29, Issue 6, 2002, Pages 707-710

  Qingnuan, Li ^a   Yan, Xiu ^b   Xiaodong, Zhang ^a   Ruili, Liu ^a   Qieqie, Du ^b   Xiaoguang, Shun ^b   Shaoliang, Chen ^b   Wenxin, Li ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

99mTc labeled; Activity test; Biodistribution; C60(OH)x; SPECT imaging

Indexed keywords

FULLERENE DERIVATIVE; TECHNETIUM 99M;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; FEMALE; ISOTOPE LABELING; KIDNEY; LIVER; MOUSE; NONHUMAN; RABBIT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPLEEN; TISSUE DISTRIBUTION;

ANIMALS; FEMALE; FULLERENES; ISOTOPE LABELING; MICE; ORGANOTECHNETIUM COMPOUNDS; RABBITS; RADIOPHARMACEUTICALS; TECHNETIUM; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; WHOLE-BODY COUNTING;

EID: 0036702145     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(02)00313-X     Document Type: Article

References (13)

1. Kroto H.W., Heath J.R., O'Brien S.C., Curl R.F., Smaliey R.E. C60, Buckminsterfullerene. Nature (London). 318:1985;162-163.
2. Friedman S.H., DeCamp D.L., Sijbesma R.P. Inhibition of the HIV-1 protease by fullerene derivatives model building studies and experimental verification . J Am Chem Soc. 115:(15):1993;6506-6509.
3. Tokuyama H., Yamago S., Nakamura E. Photoinduced biochemical activity of fullerene carboxylic acid. J Am Chem Soc. 117:1993;7918-7919.
4. Boutorine A.S., Tokuyama H., Takasugi M. Fullerene oligonucleotide conjugates photo-induced sequence-specific DNA Angew Chem . Int Ed Engl. 33:(23/24):1994;2462-2463.
5. Tiluyama H., Yamago S., Nakamura E. Photoinduced biochemical activity of fullerene carboxylic acid. J Am Chem Soc. 115:1993;7918-7919.
6. Kobayashi K., Kuwano M., Sueki K., Kikuchi K., Achiba Y., Nakahara H., Kananishi N., Wantanbe N., Tomura K. J Radioanal Nucl Chem. 192:1995;81-89.
7. Cagle D.W., Kennel S.J., Mirzadeh S. In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers. Proc Natl Acad Sci. 96:1999;5182-5187.
8. Wilson L.J., Cagle D.W., Thrash T.P. Metallofullerene drug design. Coordin Chem Rev. 192:1999;199-207.
9. 14 C labeling, absorption, distribution, excretion and acute toxicity . Chem Biol. 2:(6):1995;385-389.
10. Rajagopalan P., Wudl F., Schinazi R.F. Phamacokinetics of a water-soluble fullerene in rats. Antimicrob Agents Chemother. 40:(10):1996;2262-2265.
11. 60 fullerol formation catalysed by quaternary ammonium hydroxides. J Chem Soc Chem Commun. 1993;784-1786.
12. Chiang L.Y., Lu F.J., Lin J.T. Free radical scavenging activity of water-soluble fullerenols. J Chem Soc Chem Commun. 1995;1283-1284.
13. n,. Chem Commun. 4:1999;30-32.