Clinical evaluation and changes of the respiratory epithelium function after administration of pidotimod in Greek children with recurrent respiratory tract infections

Minerva Pediatrica

Volumn 54, Issue 4, 2002, Pages 315-319

  Aivazis, V Th ^a,b   Hatzimichail, A ^b   Papachristou, A ^b   Valeri, R ^b   Iuga Donca, G ^b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b NONE

Author keywords

Epithelial cells; Mucociliary clearance; Respiratory tract infections, drug therapy

Indexed keywords

ANTIBIOTIC AGENT; IMMUNOSTIMULATING AGENT; PIDOTIMOD;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEADACHE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFANT; MALE; NAUSEA; RANDOMIZED CONTROLLED TRIAL; RASH; RECURRENT INFECTION; RESPIRATORY EPITHELIUM; RESPIRATORY FUNCTION; RESPIRATORY TRACT INFECTION; TREATMENT INDICATION; TREATMENT OUTCOME; VOMITING;

ADJUVANTS, IMMUNOLOGIC; CHILD; CHILD, PRESCHOOL; FEMALE; GREECE; HUMANS; MALE; MUCOCILIARY CLEARANCE; PROSPECTIVE STUDIES; PYRROLIDONECARBOXYLIC ACID; RESPIRATORY MUCOSA; RESPIRATORY TRACT INFECTIONS; THIAZOLES; THIAZOLIDINES; TREATMENT OUTCOME;

EID: 0036698089     PISSN: 00264946     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Aivazis V. Respiratory epithelium and infections. Pediatrica Chronica 1992;19(4):203-12.
2. Kanakoudi F. The immune system of the human organism. Immunology-Practiki Pediatriki. Thessaloniki 1990:151-89.
3. Puigdollers JM, Rodes SG, Hemandez RI. Immunoglobulin production in man stimulated by an orally administrated bacterial lysate. Respiration 1980;40:142-5.
4. Esteves MD. Immunotherapie locate des affections respiratoires avec le Broncho-Vaxom chez l'enfant. Rev Portug Pediatr 1982;13:137-46.
5. Maestoni GS, Losa GA. Clinical and immunological effects of an orally administrated extract. Int J Immunopharmacol 1984;6:111-7.
6. Paure J. Imocur in the prevention of respiratory infections in children below six years. Ann Pediatr 1990; 37:475-9.
7. Clot J, Andary M. Immunostimulation in duite par un lysat bactérien lyophilise. Étude in vitro des réponses spécifiques et non spécifiques. Med Hyg 1980;38: 2776-9.
8. de Courten A. The role of mucosal immunity in respiratory tract infections. A new therapeutic concept. Eur J Drug Metab Pharmacol 1990;8:67-74.
9. Croviscec B, Ustar M, Gardon R, Palase KI, Stipic-Karkovic A, Zimic B. Oral immunotherapy of chronic bronchitis: a double-blind placebo-controlled multicenter study. Respiration 1989;55:129-33.
10. Collet JP. Imocur used as a preventive treatment of recurrent infections in children attending daycare centers. First annual congress of European Respiratory Society, Brussels, 1991.
11. Aivazis V, Valeri R, Pardalos G, Votsiou A, Kanakoudi-Tsakalidou F. Clinical results of bacterial immunodulator's administration (Broncho-Vaxom) in children with frequent infections of the respiratory system. Pediatrica Chronica 1994;21(1):45-50.
12. Sturgess JM, Chao J, Turner JA. Transposition of ciliary microtubules another cause of impaired ciliary motility. N Engl J Med 1980;303:318-22.
13. Carson SL, Coller MA, Shih-Chin SH. Acquired ciliary defects in nasal epithelium of child-en with acute viral upper respiratory infections. N Engl J Med 1985;312: 463-8.
14. Kaidoglou A, Aivazis V, Ikonomou L, Preponis C, Foroglou C. Abnormalities of respiratory epithelium in children with frequent respiratory tract infections. Paediatr N Gr 1990;2:14-22.
15. Kaidoglou K, Aivazis V, Alvanou A, Saricos G, Tzimakas Ch, Foroglou Chr. Ultrastructural study of bronchial epithelium, in chronic respiratory disease. Histol Histopath 1991;6:229-33.
16. Valeri R, Aivazis V, Karamperis S, Papastavrou T, Kaidoglou A, Konizoglou G. Check of the function of respiratory epithelium cilia in children with chronic respiratory problems. Helliniki Iatriki 1996;62(1):60-8.
17. Aivazis V, Valeri R, Karamperis S, Kontzoglou G, Kaidoglou A. Correlation between clearance and fine structures of respiratory epithelium in children with recurrent airw-ay diseases. Pediatrica Chronica 1998;23(3):157-63.
18. th Congress of the European Society of Pulmonology (SEP), Budapest, Hungary 5-9 Sept 1988 (in Alfred 1990).
19. Wybran J, Libin M, Schandene L. Activation of natural Killer cells and cytokine production in man by bacterial extracts. Immunopharmacol Immunotoxicol 1989;11:17-20.
20. Careddu P, Mei V. Venturoli V, Corsini A. Pidotimod in the treatment of recurrent respiratory infections in pediatric patients. Arzneim Forsch Drug Res 1994;44: 1485-9.