Metyrapone-induced corticosterone deficiency impairs glucose oxidation and steroidogenesis in Leydig cells of adult Albino rats

Endocrine Journal

Volumn 49, Issue 4, 2002, Pages 405-412

  Parthasarathy, Chandrakesan ^a   Yuvaraj, Sambandam ^a   Sivakumar, Ramadoss ^a   Sankar, Baskaran Ravi ^a   Balasubramanian, Karundevi ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

17 HSD; 14C glucose oxidation; Leydig cell; Metyrapone; Testosterone

Indexed keywords

CARBON 14; CHORIONIC GONADOTROPIN; CORTICOSTERONE; ESTRADIOL; GLUCOSE; METYRAPONE; PROLACTIN; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE RELEASE; ENZYME ACTIVITY; ESTRADIOL BLOOD LEVEL; GLUCOSE OXIDATION; HORMONE DEFICIENCY; LEYDIG CELL; MALE; NONHUMAN; RAT; STEROIDOGENESIS; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CHORIONIC GONADOTROPIN; CORTICOSTERONE; GLUCOSE; HORMONES; LEYDIG CELLS; MALE; OXIDATION-REDUCTION; PROLACTIN; PYRIDINES; RATS; RATS, WISTAR; STEROIDS; TESTOSTERONE;

EID: 0036692312     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.49.405     Document Type: Article

References (44)

1. The testis in Cushing's syndrome
2. Production rates of testosterone in patients with Cushing's syndrome
3. Acute immobilization stress disrupts testicular steroidogenesis in adult rat by inhibiting the activities of 17α hydroxylase and 17,20-lyase without affecting the binding of LH/hCG receptors
4. Effects of acute and chronic immobilization stress on rat Leydig cell steroidogenesis
5. Divergent effects of short term glucocorticoid excess on the gonadotropic and somatotropic axes in normal men
6. 5-4isomerase, 17α-hydroxylase/C17-20 lyase cytochrome P450, and cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid levels in primary cultures of mouse Leydig cells
7. Glucocorticoid-mediated repression of P450scc mRNA and de novo synthesis in cultured Leydig cells
8. Corticosterone excess impairs LH signal transduction and steroidogenesis in Leydig cells of adult rat
9. Chronic corticosterone treatment impairs Leydig cell 11β-hydroxysteroid dehydrogenase activity and LH-stimulated testosterone production
10. Glucocorticoid receptors in interstitial cells of the rat testis
11. Covalent affinity labelling, radioautography and immunocytochemistry localize the glucocorticoid receptor in rat testicular Leydig cells
12. Hormonal regulation of oxidative and reductive activities of 11β-hydroxysteroid dehydrogenase in rat Leydig cells
13. Gonadal autoantibodies in patients with hypogonadism and/or Addison's disease
14. Success of glucocorticoid replacement therapy on fertility in two adult males with 21-CAH homozygote classic form
15. Congenital adrenal hypoplasia: Clinical spectrum, experience with hormonal diagnosis, and report on new point mutations of the DAX-1 gene
16. X-linked adrenal hypoplasia congenital: A mutation in DAX-1 expands the phenotypic spectrum in males and females
17. Testicular dysfunction in adrenomyeloneuropathy
18. Influence of adrenalectomy on maturation of gonadotropin function in the male rat
19. Dissociation between cortisol and adrenal androgen secretion in patients receiving alternate-day prednisone therapy
20. Effects of metyrapone on reproductive organs of house mice
21. Chemical sterilization of males-successful inhibition of spermatogenesis in langurs (Presbytis entellus entellus dufresne) after metopiron (Su4885, Ciba) administration
22. Inhibition of rat testicular microsomal steroidogenesis by oxytocin and metyrapone
23. The effect of cell damage on the density and steroidogenic capacity of rat testis Leydig cells, using an NADH exclusive test for determination of viability
24. Steroid dehydrogenases
25. Protein measurement with the folin phenol reagent
26. Epididymal carbohydrate metabolism I. Glucose 1-14C and glucose 614C metabolism by mouse, rat and rabbit tissues
27. Epididymal carbohydrate metabolism II. Substrates and pathway utilization of caput and cauda epididymal tissues from the rabbit, rat and mouse
28. Gonadal and adrenal catheterization during adrenal suppression and gonadal stimulation in a patient with bilateral testicular tumors and congenital adrenal hyperplasia
29. Rapid regulation of corticotropin-releasing hormone gene transcription in vivo
30. Corticotropin releasing factor receptors and actions in the rat Leydig cell
31. Corticotropin-releasing factor is produced by rat Leydig cells and has a major local antireproductive role in the testis
32. Male germ cells. A new source of estrogens in the mammalian testis
33. The rat 17β-hydroxysteroid dehydrogenase type III: Molecular cloning of gonadotropin regulation
34. Altered corticosterone status impairs steroidogenesis in the granulosa and thecal cells of Wistar rats
35. Evidence for involvement of cytochrome P450-linked oxygenase system in the conversion of C21-steroids to delta 16-C-19-steroids catalyzed by pig testicular microsomes
36. The interaction of metopirone with adrenal mitochondrial cytochrome P-450. A mechanism for the inhibition of adrenal steroid 11β-hydroxylation
37. Essential role of adenosine triphosphate in activation of 17β-hydroxysteroid dehydrogenase in the rat Leydig cell
38. Leydig cell function
39. An investigation of glucose uptake in relation to steroidogenesis in rat testis and tumour Leydig cells
40. Effects of adrenalectomy and corticosterone replacement on epididymal carbohydrate metabolism. Studies on mature male rats
41. Testicular steroid biosynthesis: Organization and regulation
42. Gonadotropic hormones: Biosynthesis, secretion, receptors and actions
43. Pituitary-testis relationships: Role of prolactin in the regulation of testicular function
44. Temporal augmentation of LH by prolactin in stimulation of androgen production by the testes of hypophysectomized male rats