Effects of montelukast on physical performance and exercise economy in adult asthmatics with exercise-induced bronchoconstriction

Scandinavian Journal of Medicine and Science in Sports

Volumn 12, Issue 4, 2002, Pages 211-217

  Steinshamn, S ^a   Sandsund, M ^b   Sue Chu, M ^a   Bjermer, L ^a  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b SINTEF   (Norway)

Author keywords

Asthma; Exercise economy; Exercise induced bronchoconstriction; Montelukast

Indexed keywords

ACETIC ACID DERIVATIVE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; QUINOLINE DERIVATIVE;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BREATHING; BRONCHOSPASM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE INDUCED ASTHMA; EXERCISE TOLERANCE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATION TEST; LUNG GAS EXCHANGE; MALE; NONPARAMETRIC TEST; RANDOMIZED CONTROLLED TRIAL; SPIROMETRY;

ACETATES; ADULT; ANALYSIS OF VARIANCE; ASTHMA, EXERCISE-INDUCED; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE TOLERANCE; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LEUKOTRIENE ANTAGONISTS; MALE; PULMONARY GAS EXCHANGE; QUINOLINES; RESPIRATION; SPIROMETRY; STATISTICS, NONPARAMETRIC;

EID: 0036691025     PISSN: 09057188     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0838.2002.00225.x     Document Type: Article

References (23)

1. Anderson SD, Silverman M, Tai E, Godfrey S. Specificity of exercise in exercise-induced asthma. BMJ 1971: 4 (5790): 814-815.
2. Anderson SD, Silverman M, Walker SR. Metabolic and ventilatory changes in asthmatic patients during and after exercise. Thorax 1972: 27: 718-725.
3. Ballester E, Reyes A, Roca J, Guitart R, Wagner PD, Rodriguez-Roisin R. Ventilation-perfusion mismatching in acte severe asthma: effects of salbutamol and 100% oxygen. Thorax 1989: 44: 258-267.
4. Blake KV. Montelukast: data from clinical trials in the management of asthma (published erratum in Ann Pharmacother 2000; 34: 541). Ann Pharmacother 1999: 33: 1299-1314.
5. DaCosta J, Hedstrand U. The effect of a new sympathomimethic beta-receptor stimulating drug (terbutaline) on arterial blood gases in bronchial asthma. Scand J Respir Dis 1970: 51: 212-217.
6. Dahlen SE, Hedqvist P, Hammarstrom S, Samulesson B. Leukotrienes are potent constrictors of human bronchi. Nature 1980: 288: 484-486.
7. 4-receptor antagonism in the airways of patients with asthma. Clin Pharmacol Ther 1997: 61: 83-92.
8. Dempsey JA, Wagner PD. Exercise-induced arterial hypoxemia. J Appl Physiol 1997: 87: 1997-2006.
9. Freeman W, Nute MG, Brooks S, Williams C. Responses of asthmatic and non-asthmatic athletes to prolonged treadmill running. Br J Sports Med 1990: 24: 183-190.
10. Graff-Lonnevig V, Bevergaard S, Eriksson BO. Ventilation and pulmonary gas exchange at rest and during exercise in boys with bronchial asthma. Eur J Respir Dis 1980: 61: 357-366.
11. Holmgren D, Sixt R. Effects of salbutamol inhalations on transcutaneous blood gases in children during the acute asthmatic attack: from acute deterioration to recovery. Acta Paediatr 1994: 83: 515-519.
12. Jones NL. Clinical Exercise Testing, 4th edn. Philadelphia, London, Toronto, Montreal, Sydney, Tokyo: W.B. Saunders Company, 1997: p. 53.
13. 4 receptor antagonist. Can J Physiol Pharmacol 1995: 73: 191-201.
14. Kikawa Y, Hosoi S, Inouc Y, et al. Exercise-induced urinary excretion of leukotriene E4 in children with atopic asthma. Pediatr Res 1991: 29: 455-459.
15. Laviolette M, Malmstrom K, Lu S, et al. Montelukast added to inhaled beclomethasone in treatment of asthma. Am J Respir Crit Care Med 1999: 160: 1862-1868.
16. Leff JA, Busse WW, Pearlman D, et al. Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction (see comments). N Engl J Med 1998: 339: 147-152.
17. Munkner T, Bundgaard A. Regional V/Q changes in asthmatics after exercise. Eur J Respir Dis Suppl 1986: 143: 62-66.
18. O'Byrne PM. Leukotrienes in the pathogenesis of asthma. Chest 1997: 111 (2 Suppl.): 27S-34S.
19. Ringsted CV, Eliasen K, Andersen JB, Heslet I, Qvist J. Ventilation-perfusion distributions and central hemodynamics in chronic obstructive pulmonary disease: effects of terbutaline administration. Chest 1989: 96: 976-983.
20. Robuschi M, Riva E, Fuccella LM, et al. Prevention of exercise-induced bronchoconstriction by a new leukotriene antagonist. A double-blind study versus disodium cromoglycate and placebo. Am Rev Respir Dis 1992: 145: 1285-1288.
21. Sue-Chu M, Sandsund M, Holand B, Bjermer L. Montelukast does not affect exercise performance and subfreezing temperature in highly trained non-asthmatic endurance athletes. Int J Sports Med 2000: 21: 424-428.
22. Taylor IK, Wellings R, Taylor GW, Fuller RW. Urinary leukotriene E4 excretion in exercise-induced asthma. J Appl Physiol 1992: 73: 743-748.
23. Young IH, Corte P, Schoeffel RE. Pattern and time course of ventilation-perfusion inequality in exercise-induced asthma. Am Rev Respir Dis 1982: 125: 304-311.