Design, synthesis and biological activity of rigid cannabinoid CB 1 receptor antagonists

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 8, 2002, Pages 1109-1113

  Stoit, Axel Reinhard ^a   Lange, Jos Hubertus Maria ^a   Den Hartog, Arnold Peter ^a   Ronken, Eric ^a   Tipker, Koos ^a   Van Stuivenberg, Herman Heinrich ^a   Dijksman, Jessica Adriana Rigtje ^a   Wals, Henri Cornelis ^a   Kruse, Chris Gerrit ^a  

^a Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

Benzocycloheptapyrazole; CB1 receptor antagonist; Molecular modeling; Regiochemistry

Indexed keywords

1 (2,4 DICHLOROPHENYL) N (HEXAHYDRO 1H AZEPIN 1 YL) 8 NITRO 1,4,5,6 TETRAHYDROBENZO[6,7]CYCLOHEPTA[1,2 C]PYRAZOLE 3 CARBOXAMIDE; 4 [6 METHOXY 2 (4 METHOXYPHENYL) 3 BENZOFURANYLCARBONYL]BENZONITRILE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; CANNABINOID RECEPTOR ANTAGONIST; CP 272871; RIMONABANT; UNCLASSIFIED DRUG; CANNABINOID; CANNABINOID RECEPTOR; DRUG RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; RECEPTOR BINDING; RING CLOSING METATHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; ANIMAL; CHEMISTRY; RAT; SYNTHESIS;

ANIMALS; CANNABINOIDS; DRUG DESIGN; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0036690226     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1109     Document Type: Article

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