Synthesis of covalent [14C]-labeled diarylsulfonylurea (DASU) inhibitors of the processing and release of IL-1

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 45, Issue 9, 2002, Pages 785-794

  Eggler, J F ^a   Gabel, C A ^a   Zandi, K ^a   Weaver, J D ^a   McKechney, H ^a   Dombroski, M A ^a   Peurano, H ^a   Hawryluk, N ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

IL 1 inhibitors; 14C labeled covalent DASUs; 14C phosgene

Indexed keywords

BODY FLUIDS;

BINDING PROTEINS; HUMAN MONOCYTES; IL-1 INHIBITOR; RADIOSYNTHESIS; SULPHONAMIDES; SYNTHESISED; [14C]-LABELED COVALENT DASU; [14C]PHOSGENE;

SULFUR COMPOUNDS;

BINDING PROTEIN; CARBON 14; CP 424174; CP 452759; CP 470947; EPOXIDE; GLIBENCLAMIDE; INTERLEUKIN 1; ISOCYANIC ACID DERIVATIVE; PHOSGENE; SULFONAMIDE; SULFONYLUREA; SULFONYLUREA INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE RELEASE; DRUG SYNTHESIS; ISOTOPE LABELING; MONOCYTE; PROTEIN PROCESSING; PROTEIN PURIFICATION;

EID: 0036685104     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.602     Document Type: Article

References (7)