Inefficient transduction of sheep in utero after intra-amniotic injection of retroviral producer cells

American Journal of Obstetrics and Gynecology

Volumn 187, Issue 2, 2002, Pages 469-474

  Galan, Henry L ^a   Bennett, Michael L ^a   Tyson, R Weslie ^d   Owens, Geoffrey ^f   Regnault, Timothy R H ^b   Accurso, Frank ^e   Hobbins, John C ^a   Schaack, Jerome ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b Perinatal Research Center   (United States)

^c UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^d The Children's Hospital

^e Center for Behavioral Science   (United States)

^f Neurosciences Institute

Author keywords

Fetal sheep; Retroviral transduction inhibition

Indexed keywords

BETA GALACTOSIDASE; RETROVIRUS VECTOR;

AMNIOCENTESIS; AMNION; AMNION FLUID; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL VIABILITY; ENZYME ACTIVITY; FEMALE; FETUS; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GESTATIONAL AGE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MARKER GENE; MURINE LEUKEMIA VIRUS; NONHUMAN; PLACENTA; POLYMERASE CHAIN REACTION; PREGNANCY; PRIORITY JOURNAL; SHEEP;

EID: 0036677980     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2002.123601     Document Type: Article

References (25)

1. In utero gene transfer into the pulmonary epithelium
2. Surfactant replacement therapy in utero for prevention of hyaline membrane disease in the preterm baboon
3. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells
4. In utero gene delivery by intra-amniotic injection of a retroviral vector producer cell line in a non-human primate model
5. In situ histochemical detection of beta-galactosidase activity in lung: Assessment of X-Gal reagent in distinguishing lacZ gene expression and endogenous beta-galactosidase activity
6. Cystic fibrosis
7. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
8. Development and analysis of recombinant adenovirus for gene therapy of cystic fibrosis
9. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
10. Adenovirus mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis
11. In vivo retroviral gene transfer into human bronchial epithelia of zenografts
12. An approach for treating the heptobiliary disease of cystic fibrosis by somatic gene transfer
13. Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo
14. Early pulmonary disease in cystic fibrosis
15. In utero transfer and expression of exogenous genes in sheep
16. Retrovirus-mediated gene transfer in lungs of living fetal sheep
17. Variable efficiency of retroviral-mediated gene transfer into early-passage cultures of fetal lamb epithelial, mesenchymal, and neuroectodermal tissues
18. Amniotic fluid: Introduction
19. Paralysis of the preterm rabbit fetus inhibits the pulmonary uptake of iron dextran within the fetal lungs
20. The regulation of flow of pulmonary fluid in fetal sheep
21. Gene transfer into the fetal primate: Evidence for the secretion of transgene product
22. Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1
23. Leukemia inhibitory factor inbibits HIV-1 replication and is upregulated in placentae from nontransmitting women
24. Anti-HIV effect of beta subunit of human chorionic gonadotropin (β-HCG) in vitro
25. Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease